TEST BANK ds
Cellular and Molecular Immunology
ds ds ds
Abul Abbas, Andrew Lichtman, and Shiv Pillai
ds ds ds ds ds ds
10th Edition
ds
,Table of Contents
ds ds
Chapter 01 Properties and Overview of Immune Responses
ds d s ds d s d s ds d s 1
Chapter 02 Cells and Tissues of the Immune System
ds d s ds d s d s d s ds d s 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
ds d s d s d s d s d s d s 6
Chapter 04 Innate Immunity
ds d s d s 10
Chapter 05 Antibodies and Antigens
d s d s d s d s 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
ds d s d s d s d s d s d s d s d s ds d s
Histocompatibility Complex Moleculesd s d s 20
Chapter 07 Immune Receptors and Signal Transduction
ds d s ds d s ds d s 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
ds d s ds d s d s d s d s d s 30
Chapter 09 Activation of T Lymphocytes
d s d s d s d s d s 34
Chapter ds 10 d s Differentiation and Functions of CD4+ Effector T Cells d s d s ds d s d s d s d s 38
Chapter ds 11 d s Differentiation and Functions of CD8+ Effector T Cells d s d s ds d s d s d s d s 42
Chapter d s 12 d s B Cell Activation and Antibody Production
d s d s d s d s d s 46
Chapter ds 13 d s Effector Mechanisms of Humoral Immunity
d s ds d s d s 52
Chapter ds 14 d s Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
d s d s ds d s d s d s d s d s d s 56
Chapter ds 15 ds Immunologic Tolerance and Autoimmunity ds ds d s 62
Chapter d s 16 d s Immunity to Microbes d s d s 67
Chapter d s 17 d s Transplantation Immunology d s 72
Chapter d s 18 d s Tumor Immunology d s 77
Chapter d s 19 d s Hypersensitivity Disorders d s 81
Chapter d s 20 d s Allergy 86
Chapter d s 21 d s Primary and Acquired Immunodeficiencies
d s d s d s 89
,Chapter 01: Properties and Overview of Immune Responses
ds ds ds ds ds ds ds
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
ds ds ds ds ds ds ds ds ds
MULTIPLE CHOICE ds
1. The principal function of the immune system is:
ds ds ds ds ds ds ds
a. Defense against cancer ds ds
b. Repair of injured tissues ds ds ds
c. Defense against microbial infections ds ds ds
d. Prevention of inflammatory diseases ds ds ds
e. Protection against environmental toxins ds ds ds
ANS: C
The immune system has evolved in the setting of selective pressures imposed
d s d s d s d s d s d s d s d s d s d s d s
by microbial infections. Although immune responses to cancer may occur, the
d s ds d s d s d s d s d s d s d s ds d s
concept that ―immunosurveillance‖ against cancer is a principal function of the immune
ds d s ds ds d s ds ds ds ds d s ds ds
system is controversial. Repair of injured tissues may be a secondary
ds d s ds d s d s d s d s d s d s d s d s
consequence of the immune responses and inflammation. Although the immune
d s d s d s d s ds ds ds d s ds ds
system has regulatory features that are needed to prevent excessive inflammation,
ds d s ds ds ds ds d s d s d s d s d s
prevention of inflammatory diseases is not a
d s d s d s d s d s d s d s
primary function. The immune system can protect against microbial toxins, but it generally
ds ds ds ds ds ds ds ds ds ds ds ds
does not offer protection against toxins of nonbiologic origin.
d s d s d s d s d s d s d s d s d s
2. Which of the following infectious diseases was prevented by the first
ds ds ds ds ds ds ds ds ds ds
successful vaccination?
d s ds
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C
In 1798, Edward Jenner reported the first intentional successful vaccination,
d s d s d s ds d s d s d s d s d s
which was against smallpox in a boy, using material from the cowpox pustules
d s d s ds d s d s ds ds ds d s d s ds d s d s
of a milkmaid. In 1980, smallpox was reported to be eradicated worldwide by
ds ds ds ds ds d s d s d s d s d s d s d s d s
a vaccination program.
d s d s d s
Effective vaccines against tetanus toxin, rubella virus, and poliovirus were
d s d s d s d s ds d s d s d s d s
developed in the 20th century and are widely used. There is no effective
ds ds d s d s d s d s d s d s d s d s d s d s d s
vaccine against Mycobacterium tuberculosis.
d s d s ds ds
3. Which of the following is a unique property of the adaptive immune system?
ds ds ds ds ds ds ds ds ds ds ds ds
a. Highly diverse repertoire of specificities for antigens ds ds ds ds ds ds
b. Self-nonself discrimination ds
c. Recognition of microbial structures by both cell-associated and soluble receptors ds ds ds ds ds ds ds ds ds
d. Protection against viral infections ds ds ds
e. Responses that have the same kinetics and magnitude on repeated exposure to ds ds ds ds ds ds ds ds ds ds ds
the same microbe d s ds ds
ANS: A
, Highly diverse repertoires of specificities for antigens are found only in T
d s d s d s d s d s d s d s d s d s d s d s
and B lymphocytes, which are the central cellular components of the
d s d s ds d s d s d s d s d s d s d s d s
adaptive immune system. Both the innate and the adaptive immune systems
d s d s ds d s d s d s d s d s d s d s d s
use cell-associated and soluble receptors to recognize microbes, display some degree
d s d s d s ds ds ds ds ds ds ds ds
of self-nonself discrimination, and protect against viruses. On repeated exposure
ds ds d s d s d s d s d s d s d s d s
to the same microbe, the adaptive immune response becomes more rapid and
ds d s ds ds ds d s d s d s d s d s d s d s
of greater magnitude; this is the manifestation of memory.
d s d s d s d s d s ds ds ds ds
4. Antibodies and T lymphocytes are the respective mediators of which two types
ds ds ds ds ds ds ds ds ds ds ds
d of immunity?
s ds
a. Innate and adaptive ds ds
b. Passive and active ds ds
c. Specific and nonspecific ds ds
d. Humoral and cell-mediated ds ds
e. Adult and neonatal ds ds
ANS: D
Both B and T lymphocytes are principal components of adaptive immunity. B
d s ds d s ds d s ds d s d s d s d s d s
lymphocytes produce antibodies, which are the recognition and effector molecules of
ds ds ds ds ds ds ds ds ds ds ds
d humoral immune responses to extracellular pathogens. T cells recognize and promote
s ds ds ds ds ds ds ds ds ds ds
d eradication of intracellular pathogens in cell-mediated immunity. Passive and active
s ds ds ds ds ds ds ds ds ds
immunity both can be mediated by either B or T lymphocytes. Specific
ds d s d s d s d s d s d s d s d s d s d s d s
immunity is another term for adaptive immunity. Both B and T
d s d s ds d s d s d s d s d s d s d s d s
lymphocytes participate in adult adaptive immunity but are still developing
d s d s d s d s ds d s d s d s d s d s
in the neonatal period.
d s d s d s d s
5. The two major functional classes of effector T lymphocytes are:
ds ds ds ds ds ds ds ds ds
a. Helper T lymphocytes and cytotoxic T lymphocytes ds ds ds ds ds ds
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes ds ds ds ds
c. Memory T cells and effector T cells ds ds ds d s ds ds
d. Helper cells and antigen-presenting cells ds ds ds ds
e. Cytotoxic T lymphocytes and target cells ds ds ds ds ds
ANS: A
T cells can be classified into effector subsets that perform different effector functions.
ds ds ds ds ds ds ds ds ds ds ds ds
d Most effector T cells are either helper T lymphocytes, which enhance the
s d s d s d s d s d s d s d s d s d s d s d s
responses of other immune cells, including phagocytes and B cells, to
d s d s ds d s d s d s d s d s d s d s d s
infections, or cytotoxic T lymphocytes, which directly kill infected cells.
d s d s d s d s ds d s d s d s d s d s
Natural killer cells are not T lymphocytes.
d s d s d s d s d s d s ds
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T ds ds ds ds ds ds ds ds ds ds ds ds ds
cells.
ds
6. Which of the following cell types is required for all adaptive humoral immune
ds ds ds ds ds ds ds ds ds ds ds ds
responses?
ds
a. Natural killer cells ds ds
b. Dendritic cells ds
c. Cytolytic T lymphocytes ds ds
d. B lymphocytes d s
e. Helper T lymphocytes ds ds
ANS: D
Humoral immune responses are antibody-mediated immune responses, and all antibodies
ds ds ds ds ds ds ds ds ds
are made by B lymphocytes and no other cell type.
ds d s d s d s d s d s d s d s d s d s
Cellular and Molecular Immunology
ds ds ds
Abul Abbas, Andrew Lichtman, and Shiv Pillai
ds ds ds ds ds ds
10th Edition
ds
,Table of Contents
ds ds
Chapter 01 Properties and Overview of Immune Responses
ds d s ds d s d s ds d s 1
Chapter 02 Cells and Tissues of the Immune System
ds d s ds d s d s d s ds d s 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
ds d s d s d s d s d s d s 6
Chapter 04 Innate Immunity
ds d s d s 10
Chapter 05 Antibodies and Antigens
d s d s d s d s 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
ds d s d s d s d s d s d s d s d s ds d s
Histocompatibility Complex Moleculesd s d s 20
Chapter 07 Immune Receptors and Signal Transduction
ds d s ds d s ds d s 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
ds d s ds d s d s d s d s d s 30
Chapter 09 Activation of T Lymphocytes
d s d s d s d s d s 34
Chapter ds 10 d s Differentiation and Functions of CD4+ Effector T Cells d s d s ds d s d s d s d s 38
Chapter ds 11 d s Differentiation and Functions of CD8+ Effector T Cells d s d s ds d s d s d s d s 42
Chapter d s 12 d s B Cell Activation and Antibody Production
d s d s d s d s d s 46
Chapter ds 13 d s Effector Mechanisms of Humoral Immunity
d s ds d s d s 52
Chapter ds 14 d s Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
d s d s ds d s d s d s d s d s d s 56
Chapter ds 15 ds Immunologic Tolerance and Autoimmunity ds ds d s 62
Chapter d s 16 d s Immunity to Microbes d s d s 67
Chapter d s 17 d s Transplantation Immunology d s 72
Chapter d s 18 d s Tumor Immunology d s 77
Chapter d s 19 d s Hypersensitivity Disorders d s 81
Chapter d s 20 d s Allergy 86
Chapter d s 21 d s Primary and Acquired Immunodeficiencies
d s d s d s 89
,Chapter 01: Properties and Overview of Immune Responses
ds ds ds ds ds ds ds
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
ds ds ds ds ds ds ds ds ds
MULTIPLE CHOICE ds
1. The principal function of the immune system is:
ds ds ds ds ds ds ds
a. Defense against cancer ds ds
b. Repair of injured tissues ds ds ds
c. Defense against microbial infections ds ds ds
d. Prevention of inflammatory diseases ds ds ds
e. Protection against environmental toxins ds ds ds
ANS: C
The immune system has evolved in the setting of selective pressures imposed
d s d s d s d s d s d s d s d s d s d s d s
by microbial infections. Although immune responses to cancer may occur, the
d s ds d s d s d s d s d s d s d s ds d s
concept that ―immunosurveillance‖ against cancer is a principal function of the immune
ds d s ds ds d s ds ds ds ds d s ds ds
system is controversial. Repair of injured tissues may be a secondary
ds d s ds d s d s d s d s d s d s d s d s
consequence of the immune responses and inflammation. Although the immune
d s d s d s d s ds ds ds d s ds ds
system has regulatory features that are needed to prevent excessive inflammation,
ds d s ds ds ds ds d s d s d s d s d s
prevention of inflammatory diseases is not a
d s d s d s d s d s d s d s
primary function. The immune system can protect against microbial toxins, but it generally
ds ds ds ds ds ds ds ds ds ds ds ds
does not offer protection against toxins of nonbiologic origin.
d s d s d s d s d s d s d s d s d s
2. Which of the following infectious diseases was prevented by the first
ds ds ds ds ds ds ds ds ds ds
successful vaccination?
d s ds
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C
In 1798, Edward Jenner reported the first intentional successful vaccination,
d s d s d s ds d s d s d s d s d s
which was against smallpox in a boy, using material from the cowpox pustules
d s d s ds d s d s ds ds ds d s d s ds d s d s
of a milkmaid. In 1980, smallpox was reported to be eradicated worldwide by
ds ds ds ds ds d s d s d s d s d s d s d s d s
a vaccination program.
d s d s d s
Effective vaccines against tetanus toxin, rubella virus, and poliovirus were
d s d s d s d s ds d s d s d s d s
developed in the 20th century and are widely used. There is no effective
ds ds d s d s d s d s d s d s d s d s d s d s d s
vaccine against Mycobacterium tuberculosis.
d s d s ds ds
3. Which of the following is a unique property of the adaptive immune system?
ds ds ds ds ds ds ds ds ds ds ds ds
a. Highly diverse repertoire of specificities for antigens ds ds ds ds ds ds
b. Self-nonself discrimination ds
c. Recognition of microbial structures by both cell-associated and soluble receptors ds ds ds ds ds ds ds ds ds
d. Protection against viral infections ds ds ds
e. Responses that have the same kinetics and magnitude on repeated exposure to ds ds ds ds ds ds ds ds ds ds ds
the same microbe d s ds ds
ANS: A
, Highly diverse repertoires of specificities for antigens are found only in T
d s d s d s d s d s d s d s d s d s d s d s
and B lymphocytes, which are the central cellular components of the
d s d s ds d s d s d s d s d s d s d s d s
adaptive immune system. Both the innate and the adaptive immune systems
d s d s ds d s d s d s d s d s d s d s d s
use cell-associated and soluble receptors to recognize microbes, display some degree
d s d s d s ds ds ds ds ds ds ds ds
of self-nonself discrimination, and protect against viruses. On repeated exposure
ds ds d s d s d s d s d s d s d s d s
to the same microbe, the adaptive immune response becomes more rapid and
ds d s ds ds ds d s d s d s d s d s d s d s
of greater magnitude; this is the manifestation of memory.
d s d s d s d s d s ds ds ds ds
4. Antibodies and T lymphocytes are the respective mediators of which two types
ds ds ds ds ds ds ds ds ds ds ds
d of immunity?
s ds
a. Innate and adaptive ds ds
b. Passive and active ds ds
c. Specific and nonspecific ds ds
d. Humoral and cell-mediated ds ds
e. Adult and neonatal ds ds
ANS: D
Both B and T lymphocytes are principal components of adaptive immunity. B
d s ds d s ds d s ds d s d s d s d s d s
lymphocytes produce antibodies, which are the recognition and effector molecules of
ds ds ds ds ds ds ds ds ds ds ds
d humoral immune responses to extracellular pathogens. T cells recognize and promote
s ds ds ds ds ds ds ds ds ds ds
d eradication of intracellular pathogens in cell-mediated immunity. Passive and active
s ds ds ds ds ds ds ds ds ds
immunity both can be mediated by either B or T lymphocytes. Specific
ds d s d s d s d s d s d s d s d s d s d s d s
immunity is another term for adaptive immunity. Both B and T
d s d s ds d s d s d s d s d s d s d s d s
lymphocytes participate in adult adaptive immunity but are still developing
d s d s d s d s ds d s d s d s d s d s
in the neonatal period.
d s d s d s d s
5. The two major functional classes of effector T lymphocytes are:
ds ds ds ds ds ds ds ds ds
a. Helper T lymphocytes and cytotoxic T lymphocytes ds ds ds ds ds ds
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes ds ds ds ds
c. Memory T cells and effector T cells ds ds ds d s ds ds
d. Helper cells and antigen-presenting cells ds ds ds ds
e. Cytotoxic T lymphocytes and target cells ds ds ds ds ds
ANS: A
T cells can be classified into effector subsets that perform different effector functions.
ds ds ds ds ds ds ds ds ds ds ds ds
d Most effector T cells are either helper T lymphocytes, which enhance the
s d s d s d s d s d s d s d s d s d s d s d s
responses of other immune cells, including phagocytes and B cells, to
d s d s ds d s d s d s d s d s d s d s d s
infections, or cytotoxic T lymphocytes, which directly kill infected cells.
d s d s d s d s ds d s d s d s d s d s
Natural killer cells are not T lymphocytes.
d s d s d s d s d s d s ds
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T ds ds ds ds ds ds ds ds ds ds ds ds ds
cells.
ds
6. Which of the following cell types is required for all adaptive humoral immune
ds ds ds ds ds ds ds ds ds ds ds ds
responses?
ds
a. Natural killer cells ds ds
b. Dendritic cells ds
c. Cytolytic T lymphocytes ds ds
d. B lymphocytes d s
e. Helper T lymphocytes ds ds
ANS: D
Humoral immune responses are antibody-mediated immune responses, and all antibodies
ds ds ds ds ds ds ds ds ds
are made by B lymphocytes and no other cell type.
ds d s d s d s d s d s d s d s d s d s
