NR 565 Advanced Pharmacology Midterm Exam Chamberlain
Actual Questions with 100% Correct Answers
Updated & Verified
1. During what trimester is a pregnant woman most at risk for adverse drug
reactions with potential long term consequences?
Answer> 1st trimester (fetus most at risk d/t rapid growth)
2. What is BEERS criteria?
Answer> Recommendations of medications inappropriate for elderly (65 and
older), prescriber ultimately decides
3. What is the CYP450 (cytochrome P450)
Answer> liver enzyme system where medica- tions are metabolized, can either be
inducers or inhibitors and create drug-drug interactions
4. CYP450 inducers
,Answer> Speed up metabolism of drugs (drug is cleared faster), drug has lesser
effect (decrease blood levels of drug), elevate CYP450 enzymes
5. CYP450 inducers pneumonic
Answer> "Bullshit Crap GPS INDUCES rage"
6. CYP450 inducer drug names
Answer> Barbituates, St John wort, Carbamazepine, ri- fampin, alcohol, phenytoin,
griseofulvin, phenobarbital, sulfonylureas
7. CYP450 inhibitors
Answer> inhibit metabolism, increase blood levels of medications
8. CYP450 pneumonic
Answer> "VISA credit card debt INHIBITS spending on designers like CK to look
GQ"
9. CYP450 inhibitors drug names
Answer> Valproate, isoniazid, sulfonamides, amio- darone, chloramphenicol,
ketoconazole, grapefruit juice, quinidine
10. Physiological changes during pregnancy that impact pharmacodynamics
and pharmacokinetic properties of drugs?
,Answer> increase glomerular filtration rate leads to increase durg excretion
increase hepatic metabolism decrease
tone and motility of bowel increase
drug absorption
11. Examples of medications that can be teratogenic
Answer> Antiepileptic drugs, an- timicrobials such as tetracyclines and
fluoroquinolones, vitamin A in large doses, some anticoagulants, and hormonal
medications such as diethylstilbestrol (DES).
12. How is absorption of intramuscular medications different in neonates?
Answer> -
slow and erratic due to low blood flow in muscles first few days of life
13. Why is absorption of medication in the stomach increased in infancy?
Answer> de- layed gastric emptying
14. Some medications that should be avoided in the pediatric patient?
Answer> glu- cocorticoids, discoloration of developing teeth with tetracyclines,
and kernicterus with sulfonamides, levofloxacin (antibiotics)
aspirin (Severe intoxication from acute overdose)
, 15. what should be included in medication administration patient education?-
Answer> dosage size and timing
route and technique of administration
duration of treatment
drug storage
nature and time course of desired responses
nature and time course of adverse responses
finish taking antibiotic
16. What are some things that put the elderly patient at higher risk for adverse
drug reactions?
Answer> reduced renal function
polypharmacy (the use of five or more medications daily)
greater severity of illness
presence of comorbidities
use of drugs that have a low therapeutic index (e.g., digoxin) increased
Actual Questions with 100% Correct Answers
Updated & Verified
1. During what trimester is a pregnant woman most at risk for adverse drug
reactions with potential long term consequences?
Answer> 1st trimester (fetus most at risk d/t rapid growth)
2. What is BEERS criteria?
Answer> Recommendations of medications inappropriate for elderly (65 and
older), prescriber ultimately decides
3. What is the CYP450 (cytochrome P450)
Answer> liver enzyme system where medica- tions are metabolized, can either be
inducers or inhibitors and create drug-drug interactions
4. CYP450 inducers
,Answer> Speed up metabolism of drugs (drug is cleared faster), drug has lesser
effect (decrease blood levels of drug), elevate CYP450 enzymes
5. CYP450 inducers pneumonic
Answer> "Bullshit Crap GPS INDUCES rage"
6. CYP450 inducer drug names
Answer> Barbituates, St John wort, Carbamazepine, ri- fampin, alcohol, phenytoin,
griseofulvin, phenobarbital, sulfonylureas
7. CYP450 inhibitors
Answer> inhibit metabolism, increase blood levels of medications
8. CYP450 pneumonic
Answer> "VISA credit card debt INHIBITS spending on designers like CK to look
GQ"
9. CYP450 inhibitors drug names
Answer> Valproate, isoniazid, sulfonamides, amio- darone, chloramphenicol,
ketoconazole, grapefruit juice, quinidine
10. Physiological changes during pregnancy that impact pharmacodynamics
and pharmacokinetic properties of drugs?
,Answer> increase glomerular filtration rate leads to increase durg excretion
increase hepatic metabolism decrease
tone and motility of bowel increase
drug absorption
11. Examples of medications that can be teratogenic
Answer> Antiepileptic drugs, an- timicrobials such as tetracyclines and
fluoroquinolones, vitamin A in large doses, some anticoagulants, and hormonal
medications such as diethylstilbestrol (DES).
12. How is absorption of intramuscular medications different in neonates?
Answer> -
slow and erratic due to low blood flow in muscles first few days of life
13. Why is absorption of medication in the stomach increased in infancy?
Answer> de- layed gastric emptying
14. Some medications that should be avoided in the pediatric patient?
Answer> glu- cocorticoids, discoloration of developing teeth with tetracyclines,
and kernicterus with sulfonamides, levofloxacin (antibiotics)
aspirin (Severe intoxication from acute overdose)
, 15. what should be included in medication administration patient education?-
Answer> dosage size and timing
route and technique of administration
duration of treatment
drug storage
nature and time course of desired responses
nature and time course of adverse responses
finish taking antibiotic
16. What are some things that put the elderly patient at higher risk for adverse
drug reactions?
Answer> reduced renal function
polypharmacy (the use of five or more medications daily)
greater severity of illness
presence of comorbidities
use of drugs that have a low therapeutic index (e.g., digoxin) increased
