TEST BANKg
Cellular and Molecular Immunology
g g g
Abul Abbas, Andrew Lichtman, and Shiv Pillai
g g g g g g
10th Edition
g
PlusBay.Plus
,Table of Contents
g g
Chapterg01gPropertiesgandgOverviewgofgImmunegResponses 1
Chapterg02gCellsgandgTissuesgofgthegImmunegSystem 3
Chapterg03gLeukocytegCirculationgandgMigrationgIntogTissues 6
Chapterg04gInnategImmunity 10
Chapterg05gAntibodiesgandgAntigens 17
Chapterg06gAntigengPresentationgtogTgLymphocytesgandgthegFunctionsgofgMajor
HistocompatibilitygComplexgMolecules 20
Chapterg07gImmunegReceptorsgandgSignalgTransduction 27
Chapterg08gLymphocytegDevelopmentgandgAntigengReceptorgGenegRearrangement 30
Chapterg09gActivationgofgTgLymphocytes 34
Chapterg10gDifferentiationgandgFunctionsgofgCD4+gEffectorgTgCells 38
Chapterg11gDifferentiationgandgFunctionsgofgCD8+gEffectorgTgCells 42
Chapterg12gBgCellgActivationgandgAntibodygProduction 46
Chapterg13gEffectorgMechanismsgofgHumoralgImmunity 52
Chapterg14gSpecializedgImmunitygatgEpithelialgBarriersgandgingImmunegPrivilegedgTissues 56
Chapterg15gImmunologicgTolerancegandgAutoimmunity 62
Chapterg16gImmunitygtogMicrobes 67
Chapterg17gTransplantationgImmunology 72
Chapterg18gTumorgImmunology 77
Chapterg19gHypersensitivitygDisorders 81
Chapterg20gAllergy 86
Chapterg21gPrimarygandgAcquiredgImmunodeficiencies 89
PlusBay.Plus
,Chapter 01: Properties and Overview of Immune Responses
g g g g g g g
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
g g g g g g g g g
MULTIPLEgCHOICE
1. Thegprincipalgfunctiongofgthegimmunegsystemgis:
a. Defensegagainstgcancer
b. Repairgofginjuredgtissues
c. Defensegagainstgmicrobialginfections
d. Preventiongofginflammatorygdiseases
e. Protectiongagainstgenvironmentalgtoxins
ANS:g g C
Thegimmunegsystemghasgevolvedgingthegsettinggofgselectivegpressuresgimposedgbygmicrobialginfe
ctions.gAlthoughgimmunegresponsesgtogcancergmaygoccur,gthegconceptgthatg“immunosurveillanc
e”gagainstgcancergisgagprincipalgfunctiongofgthegimmunegsystemgisgcontroversial.gRepairgofginjure
dgtissuesgmaygbegagsecondarygconsequencegofgthegimmunegresponsesgandginflammation.gAlthoug
hgthegimmunegsystemghasgregulatorygfeaturesgthatgaregneededgtogpreventgexcessiveginflammation
,gpreventiongofginflammatorygdiseasesgisgnotgagprimarygfunction.gThegimmunegsystemgcangprotect
gagainstgmicrobialgtoxins,gbutgitggenerallygdoesgnotgoffergprotectiongagainstgtoxinsgofgnonbiologic
gorigin.
2. Whichgofgthegfollowingginfectiousgdiseasesgwasgpreventedgbygthegfirstgsuccessfulg
vaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS:g g C
Ing1798,gEdwardgJennergreportedgthegfirstgintentionalgsuccessfulgvaccination,gwhichgwasgagai
nstgsmallpoxgingagboy,gusinggmaterialgfromgthegcowpoxgpustulesgofgagmilkmaid.gIng1980,gsmall
poxgwasgreportedgtogbegeradicatedgworldwidegbygagvaccinationgprogram.gEffectivegvaccinesga
gainstgtetanusgtoxin,grubellagvirus,gandgpoliovirusgweregdevelopedgingtheg20thgcenturygandgareg
widelygused.gTheregisgnogeffectivegvaccinegagainstgMycobacteriumgtuberculosis.
3. Whichgofgthegfollowinggisgaguniquegpropertygofgthegadaptivegimmunegsystem?
a. Highlygdiversegrepertoiregofgspecificitiesgforgantigens
b. Self-nonselfg discrimination
c. Recognitiongofgmicrobialgstructuresgbygbothgcell-associatedgandgsolublegreceptors
d. Protectiongagainstgviralginfections
e. Responsesgthatghavegthegsamegkineticsgandgmagnitudegongrepeatedgexposuregtogthegs
amegmicrobe
ANS:g g A
PlusBay.Plus
, HighlygdiversegrepertoiresgofgspecificitiesgforgantigensgaregfoundgonlygingTgandgBglymphocyte
s,gwhichgaregthegcentralgcellulargcomponentsgofgthegadaptivegimmunegsystem.gBothgtheginnateg
andgthegadaptivegimmunegsystemsgusegcell-
associatedgandgsolublegreceptorsgtogrecognizegmicrobes,gdisplaygsomegdegreegofgself-
nonselfgdiscrimination,gandgprotectgagainstgviruses.gOngrepeatedgexposuregtogthegsamegmicrob
e,gthegadaptivegimmunegresponsegbecomesgmoregrapidgandgofggreatergmagnitude;gthisgisgthegm
anifestationgofgmemory.
4. AntibodiesgandgTglymphocytesgaregthegrespectivegmediatorsgofgwhichgtwogtypesgofgi
mmunity?
a. Innategandgadaptive
b. Passivegandgactive
c. Specificgandgnonspecific
d. Humoralgandgcell-mediated
e. Adultgandgneonatal
ANS:g g D
BothgBgandgTglymphocytesgaregprincipalgcomponentsgofgadaptivegimmunity.gBglymphocytesgp
roducegantibodies,gwhichgaregthegrecognitiongandgeffectorgmoleculesgofghumoralgimmunegresp
onsesgtogextracellulargpathogens.gTgcellsgrecognizegandgpromotegeradicationgofgintracellulargpa
thogensgingcell-
mediatedgimmunity.gPassivegandgactivegimmunitygbothgcangbegmediatedgbygeithergBgorgTglymp
hocytes.gSpecificgimmunitygisganothergtermgforgadaptivegimmunity.gBothgBgandgTglymphocytes
gparticipategingadultgadaptivegimmunitygbutgaregstillgdevelopinggingthegneonatalgperiod.
5. ThegtwogmajorgfunctionalgclassesgofgeffectorgTglymphocytesgare:
a. HelpergTglymphocytesgandgcytotoxicgTglymphocytes
b. NaturalgkillergcellsgandgcytoWtoWxW
ic.TTlBSM
ymph.oW
cyStes
c. MemorygTgcellsgandgeffectorgTgcells
d. Helpergcellsgandgantigen-presentinggcells
e. CytotoxicgTglymphocytesgandgtargetgcells
ANS:g g A
Tgcellsgcangbegclassifiedgintogeffectorgsubsetsgthatgperformgdifferentgeffectorgfunctions.gMostge
ffectorgTgcellsgaregeitherghelpergTglymphocytes,gwhichgenhancegthegresponsesgofgothergimmun
egcells,gincludinggphagocytesgandgBgcells,gtoginfections,gorgcytotoxicgTglymphocytes,gwhichgdi
rectlygkillginfectedgcells.gNaturalgkillergcellsgaregnotgTglymphocytes.
Antigen-presentinggcellsgusuallygaregnotgTgcells.gMemorygTgcellsgaregnotgeffectorgTgcells.
6. Whichgofgthegfollowinggcellgtypesgisgrequiredgforgallgadaptiveghumoralgimmunegresponses?
a. Naturalgkillergcells
b. Dendriticgcells
c. CytolyticgTglymphocytes
d. Bglymphocytes
e. HelpergTglymphocytes
ANS:g g D
Humoralgimmunegresponsesgaregantibody-
mediatedgimmunegresponses,gandgallgantibodiesgaregmadegbygBglymphocytesgandgnogothergcell
gtype.
PlusBay.Plus
Cellular and Molecular Immunology
g g g
Abul Abbas, Andrew Lichtman, and Shiv Pillai
g g g g g g
10th Edition
g
PlusBay.Plus
,Table of Contents
g g
Chapterg01gPropertiesgandgOverviewgofgImmunegResponses 1
Chapterg02gCellsgandgTissuesgofgthegImmunegSystem 3
Chapterg03gLeukocytegCirculationgandgMigrationgIntogTissues 6
Chapterg04gInnategImmunity 10
Chapterg05gAntibodiesgandgAntigens 17
Chapterg06gAntigengPresentationgtogTgLymphocytesgandgthegFunctionsgofgMajor
HistocompatibilitygComplexgMolecules 20
Chapterg07gImmunegReceptorsgandgSignalgTransduction 27
Chapterg08gLymphocytegDevelopmentgandgAntigengReceptorgGenegRearrangement 30
Chapterg09gActivationgofgTgLymphocytes 34
Chapterg10gDifferentiationgandgFunctionsgofgCD4+gEffectorgTgCells 38
Chapterg11gDifferentiationgandgFunctionsgofgCD8+gEffectorgTgCells 42
Chapterg12gBgCellgActivationgandgAntibodygProduction 46
Chapterg13gEffectorgMechanismsgofgHumoralgImmunity 52
Chapterg14gSpecializedgImmunitygatgEpithelialgBarriersgandgingImmunegPrivilegedgTissues 56
Chapterg15gImmunologicgTolerancegandgAutoimmunity 62
Chapterg16gImmunitygtogMicrobes 67
Chapterg17gTransplantationgImmunology 72
Chapterg18gTumorgImmunology 77
Chapterg19gHypersensitivitygDisorders 81
Chapterg20gAllergy 86
Chapterg21gPrimarygandgAcquiredgImmunodeficiencies 89
PlusBay.Plus
,Chapter 01: Properties and Overview of Immune Responses
g g g g g g g
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
g g g g g g g g g
MULTIPLEgCHOICE
1. Thegprincipalgfunctiongofgthegimmunegsystemgis:
a. Defensegagainstgcancer
b. Repairgofginjuredgtissues
c. Defensegagainstgmicrobialginfections
d. Preventiongofginflammatorygdiseases
e. Protectiongagainstgenvironmentalgtoxins
ANS:g g C
Thegimmunegsystemghasgevolvedgingthegsettinggofgselectivegpressuresgimposedgbygmicrobialginfe
ctions.gAlthoughgimmunegresponsesgtogcancergmaygoccur,gthegconceptgthatg“immunosurveillanc
e”gagainstgcancergisgagprincipalgfunctiongofgthegimmunegsystemgisgcontroversial.gRepairgofginjure
dgtissuesgmaygbegagsecondarygconsequencegofgthegimmunegresponsesgandginflammation.gAlthoug
hgthegimmunegsystemghasgregulatorygfeaturesgthatgaregneededgtogpreventgexcessiveginflammation
,gpreventiongofginflammatorygdiseasesgisgnotgagprimarygfunction.gThegimmunegsystemgcangprotect
gagainstgmicrobialgtoxins,gbutgitggenerallygdoesgnotgoffergprotectiongagainstgtoxinsgofgnonbiologic
gorigin.
2. Whichgofgthegfollowingginfectiousgdiseasesgwasgpreventedgbygthegfirstgsuccessfulg
vaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS:g g C
Ing1798,gEdwardgJennergreportedgthegfirstgintentionalgsuccessfulgvaccination,gwhichgwasgagai
nstgsmallpoxgingagboy,gusinggmaterialgfromgthegcowpoxgpustulesgofgagmilkmaid.gIng1980,gsmall
poxgwasgreportedgtogbegeradicatedgworldwidegbygagvaccinationgprogram.gEffectivegvaccinesga
gainstgtetanusgtoxin,grubellagvirus,gandgpoliovirusgweregdevelopedgingtheg20thgcenturygandgareg
widelygused.gTheregisgnogeffectivegvaccinegagainstgMycobacteriumgtuberculosis.
3. Whichgofgthegfollowinggisgaguniquegpropertygofgthegadaptivegimmunegsystem?
a. Highlygdiversegrepertoiregofgspecificitiesgforgantigens
b. Self-nonselfg discrimination
c. Recognitiongofgmicrobialgstructuresgbygbothgcell-associatedgandgsolublegreceptors
d. Protectiongagainstgviralginfections
e. Responsesgthatghavegthegsamegkineticsgandgmagnitudegongrepeatedgexposuregtogthegs
amegmicrobe
ANS:g g A
PlusBay.Plus
, HighlygdiversegrepertoiresgofgspecificitiesgforgantigensgaregfoundgonlygingTgandgBglymphocyte
s,gwhichgaregthegcentralgcellulargcomponentsgofgthegadaptivegimmunegsystem.gBothgtheginnateg
andgthegadaptivegimmunegsystemsgusegcell-
associatedgandgsolublegreceptorsgtogrecognizegmicrobes,gdisplaygsomegdegreegofgself-
nonselfgdiscrimination,gandgprotectgagainstgviruses.gOngrepeatedgexposuregtogthegsamegmicrob
e,gthegadaptivegimmunegresponsegbecomesgmoregrapidgandgofggreatergmagnitude;gthisgisgthegm
anifestationgofgmemory.
4. AntibodiesgandgTglymphocytesgaregthegrespectivegmediatorsgofgwhichgtwogtypesgofgi
mmunity?
a. Innategandgadaptive
b. Passivegandgactive
c. Specificgandgnonspecific
d. Humoralgandgcell-mediated
e. Adultgandgneonatal
ANS:g g D
BothgBgandgTglymphocytesgaregprincipalgcomponentsgofgadaptivegimmunity.gBglymphocytesgp
roducegantibodies,gwhichgaregthegrecognitiongandgeffectorgmoleculesgofghumoralgimmunegresp
onsesgtogextracellulargpathogens.gTgcellsgrecognizegandgpromotegeradicationgofgintracellulargpa
thogensgingcell-
mediatedgimmunity.gPassivegandgactivegimmunitygbothgcangbegmediatedgbygeithergBgorgTglymp
hocytes.gSpecificgimmunitygisganothergtermgforgadaptivegimmunity.gBothgBgandgTglymphocytes
gparticipategingadultgadaptivegimmunitygbutgaregstillgdevelopinggingthegneonatalgperiod.
5. ThegtwogmajorgfunctionalgclassesgofgeffectorgTglymphocytesgare:
a. HelpergTglymphocytesgandgcytotoxicgTglymphocytes
b. NaturalgkillergcellsgandgcytoWtoWxW
ic.TTlBSM
ymph.oW
cyStes
c. MemorygTgcellsgandgeffectorgTgcells
d. Helpergcellsgandgantigen-presentinggcells
e. CytotoxicgTglymphocytesgandgtargetgcells
ANS:g g A
Tgcellsgcangbegclassifiedgintogeffectorgsubsetsgthatgperformgdifferentgeffectorgfunctions.gMostge
ffectorgTgcellsgaregeitherghelpergTglymphocytes,gwhichgenhancegthegresponsesgofgothergimmun
egcells,gincludinggphagocytesgandgBgcells,gtoginfections,gorgcytotoxicgTglymphocytes,gwhichgdi
rectlygkillginfectedgcells.gNaturalgkillergcellsgaregnotgTglymphocytes.
Antigen-presentinggcellsgusuallygaregnotgTgcells.gMemorygTgcellsgaregnotgeffectorgTgcells.
6. Whichgofgthegfollowinggcellgtypesgisgrequiredgforgallgadaptiveghumoralgimmunegresponses?
a. Naturalgkillergcells
b. Dendriticgcells
c. CytolyticgTglymphocytes
d. Bglymphocytes
e. HelpergTglymphocytes
ANS:g g D
Humoralgimmunegresponsesgaregantibody-
mediatedgimmunegresponses,gandgallgantibodiesgaregmadegbygBglymphocytesgandgnogothergcell
gtype.
PlusBay.Plus
