TEST BANK COMPLETE_
BASIC AND CLINICAL PHARMACOLOGY 15TH EDITION,
(2020)
BY BERTRAM G. KATZUNG & ANTHONY J. TREVOR
ALL CHAPTERS 1-67 COVERED| EDITION WITH WELL DETAILED ANSWERS| GRADE A+
15TH EDITION
,SECTION 1: BASIC PRINCIPLES_________________________________________ 5
CHAPTER 1. INTRODUCTION: THE NATURE OF DRUGS & DRUG DEVELOPMENT & REGULATION ______ 5
CHAPTER 2. DRUG RECEPTORS & PHARMACODYNAMICS ______________________________________ 21
CHAPTER 3. PHARMACOKINETICS & PHARMACODYNAMICS: RATIONAL DOSING & THE TIME COURSE
OF DRUG ACTION ________________________________________________________________________ 37
CHAPTER 4. DRUG BIOTRANSFORMATION ___________________________________________________ 48
CHAPTER 5. PHARMACOGENOMICS _________________________________________________________ 59
SECTION 2: AUTONOMIC DRUGS ______________________________________ 66
CHAPTER 6. INTRODUCTION TO AUTONOMIC PHARMACOLOGY _________________________________ 66
CHAPTER 7. CHOLINOCEPTOR-ACTIVATING & CHOLINESTERASE-INHIBITING DRUGS ______________ 82
CHAPTER 8. CHOLINOCEPTOR-BLOCKING DRUGS ____________________________________________ 96
CHAPTER 9. ADRENOCEPTOR AGONISTS & SYMPATHOMIMETIC DRUGS ________________________ 110
CHAPTER 10. ADRENOCEPTOR ANTAGONIST DRUGS ________________________________________ 124
SECTION 3: CARDIOVASCULAR-RENAL DRUGS _________________________ 138
CHAPTER 11. ANTIHYPERTENSIVE AGENTS _________________________________________________ 138
CHAPTER 12. VASODILATORS & THE TREATMENT OF ANGINA PECTORIS _______________________ 153
CHAPTER 13. DRUGS USED IN HEART FAILURE ______________________________________________ 167
CHAPTER 14. AGENTS USED IN CARDIAC ARRHYTHMIAS _____________________________________ 180
CHAPTER 15. DIURETIC AGENTS ___________________________________________________________ 194
SECTION 4: DRUGS WITH IMPORTANT ACTIONS ON SMOOTH MUSCLE _____ 208
CHAPTER 16. HISTAMINE, SEROTONIN, & THE ERGOT ALKALOIDS _____________________________ 208
CHAPTER 17. VASOACTIVE PEPTIDES ______________________________________________________ 218
CHAPTER 18. THE EICOSANOIDS: PROSTAGLANDINS, THROMBOXANES, LEUKOTRIENES, & RELATED
COMPOUNDS ___________________________________________________________________________ 225
CHAPTER 19. NITRIC OXIDE _______________________________________________________________ 231
CHAPTER 20. DRUGS USED IN ASTHMA & CHRONIC OBSTRUCTIVE PULMONARY DISEASE ________ 245
SECTION 5: DRUGS THAT ACT IN THE CENTRAL NERVOUS SYSTEM _______ 257
CHAPTER 21. INTRODUCTION TO THE PHARMACOLOGY OF CNS DRUGS ________________________ 257
CHAPTER 22. SEDATIVE-HYPNOTIC DRUGS _________________________________________________ 269
CHAPTER 23. THE ALCOHOLS _____________________________________________________________ 284
CHAPTER 24. ANTISEIZURE DRUGS ________________________________________________________ 297
CHAPTER 25. GENERAL ANESTHETICS _____________________________________________________ 311
CHAPTER 26. LOCAL ANESTHETICS ________________________________________________________ 325
CHAPTER 27. SKELETAL MUSCLE RELAXANTS ______________________________________________ 338
CHAPTER 28. PHARMACOLOGIC MANAGEMENT OF PARKINSONISM & OTHER MOVEMENT DISORDERS
_______________________________________________________________________________________ 352
, CHAPTER 29. ANTIPSYCHOTIC AGENTS & LITHIUM ___________________________________________ 365
CHAPTER 30. ANTIDEPRESSANT AGENTS ___________________________________________________ 379
CHAPTER 31. OPIOID AGONISTS & ANTAGONISTS ____________________________________________ 395
CHAPTER 32. DRUGS OF ABUSE ___________________________________________________________ 408
SECTION 6: DRUGS USED TO TREAT DISEASES OF THE BLOOD,
INFLAMMATION, & GOUT ____________________________________________ 419
CHAPTER 33. AGENTS USED IN CYTOPENIAS; HEMATOPOIETIC GROWTH FACTORS ______________ 419
CHAPTER 34. DRUGS USED IN DISORDERS OF COAGULATION _________________________________ 433
CHAPTER 35. AGENTS USED IN DYSLIPIDEMIA_______________________________________________ 446
CHAPTER 36. NONSTEROIDAL ANTI-INFLAMMATORY DRUGS, DISEASE-MODIFYING ANTIRHEUMATIC
DRUGS, NONOPIOID ANALGESICS, & DRUGS USED IN GOUT ___________________________________ 461
SECTION 7: ENDOCRINE DRUGS ______________________________________ 475
CHAPTER 37. HYPOTHALAMIC & PITUITARY HORMONES ______________________________________ 475
CHAPTER 38. THYROID & ANTITHYROID DRUGS _____________________________________________ 489
CHAPTER 39. ADRENOCORTICOSTEROIDS & ADRENOCORTICAL ANTAGONISTS _________________ 503
CHAPTER 40. THE GONADAL HORMONES & INHIBITORS ______________________________________ 518
CHAPTER 41. PANCREATIC HORMONES & GLUCOSE-LOWERING DRUGS ________________________ 533
CHAPTER 42. AGENTS THAT AFFECT BONE MINERAL HOMEOSTASIS ___________________________ 547
SECTION 8: CHEMOTHERAPEUTIC DRUGS _____________________________ 563
CHAPTER 43. BETA-LACTAM & OTHER CELL WALL- & MEMBRANE-ACTIVE ANTIBIOTICS __________ 563
CHAPTER 44. TETRACYCLINES, MACROLIDES, CLINDAMYCIN, CHLORAMPHENICOL,
STREPTOGRAMINS, OXAZOLIDINONES, & PLEUROMUTILINS __________________________________ 579
CHAPTER 45. AMINOGLYCOSIDES & SPECTINOMYCIN ________________________________________ 591
CHAPTER 46. SULFONAMIDES, TRIMETHOPRIM, & QUINOLONES _______________________________ 602
CHAPTER 47. ANTIMYCOBACTERIAL DRUGS ________________________________________________ 614
CHAPTER 48. ANTIFUNGAL AGENTS _______________________________________________________ 625
CHAPTER 49. ANTIVIRAL AGENTS _________________________________________________________ 639
CHAPTER 50. MISCELLANEOUS ANTIMICROBIAL AGENTS; DISINFECTANTS, ANTISEPTICS, &
STERILANTS ____________________________________________________________________________ 654
CHAPTER 51. CLINICAL USE OF ANTIMICROBIAL AGENTS _____________________________________ 670
CHAPTER 52. ANTIPROTOZOAL DRUGS _____________________________________________________ 683
CHAPTER 53. PHARMACOLOGY OF THE ANTIHELMINTHIC DRUGS ______________________________ 697
CHAPTER 54. CANCER CHEMOTHERAPY ____________________________________________________ 711
CHAPTER 55. IMMUNOPHARMACOLOGY ____________________________________________________ 727
SECTION 9: TOXICOLOGY ___________________________________________ 742
CHAPTER 56. INTRODUCTION TO TOXICOLOGY: OCCUPATIONAL & ENVIRONMENTAL_____________ 742
CHAPTER 57. HEAVY METAL INTOXICATION & CHELATORS ___________________________________ 768
CHAPTER 58. MANAGEMENT OF THE POISONED PATIENT _____________________________________ 779
, SECTION 10: SPECIAL TOPICS _______________________________________ 791
CHAPTER 59. SPECIAL ASPECTS OF PERINATAL & PEDIATRIC PHARMACOLOGY _________________ 791
CHAPTER 60. SPECIAL ASPECTS OF GERIATRIC PHARMACOLOGY _____________________________ 798
CHAPTER 61. DERMATOLOGIC PHARMACOLOGY ____________________________________________ 803
CHAPTER 62. DRUGS USED IN THE TREATMENT OF GASTROINTESTINAL DISEASES ______________ 808
CHAPTER 63. CANNABINOID DRUGS _______________________________________________________ 822
CHAPTER 64. THERAPEUTIC & TOXIC POTENTIAL OF OVER-THE-COUNTER AGENTS ______________ 834
CHAPTER 65. DIETARY SUPPLEMENTS & HERBAL MEDICATIONS ______________________________ 849
CHAPTER 66. RATIONAL PRESCRIBING & PRESCRIPTION WRITING _____________________________ 852
CHAPTER 67. IMPORTANT DRUG INTERACTIONS & THEIR MECHANISMS ________________________ 869
BASIC AND CLINICAL PHARMACOLOGY 15TH EDITION,
(2020)
BY BERTRAM G. KATZUNG & ANTHONY J. TREVOR
ALL CHAPTERS 1-67 COVERED| EDITION WITH WELL DETAILED ANSWERS| GRADE A+
15TH EDITION
,SECTION 1: BASIC PRINCIPLES_________________________________________ 5
CHAPTER 1. INTRODUCTION: THE NATURE OF DRUGS & DRUG DEVELOPMENT & REGULATION ______ 5
CHAPTER 2. DRUG RECEPTORS & PHARMACODYNAMICS ______________________________________ 21
CHAPTER 3. PHARMACOKINETICS & PHARMACODYNAMICS: RATIONAL DOSING & THE TIME COURSE
OF DRUG ACTION ________________________________________________________________________ 37
CHAPTER 4. DRUG BIOTRANSFORMATION ___________________________________________________ 48
CHAPTER 5. PHARMACOGENOMICS _________________________________________________________ 59
SECTION 2: AUTONOMIC DRUGS ______________________________________ 66
CHAPTER 6. INTRODUCTION TO AUTONOMIC PHARMACOLOGY _________________________________ 66
CHAPTER 7. CHOLINOCEPTOR-ACTIVATING & CHOLINESTERASE-INHIBITING DRUGS ______________ 82
CHAPTER 8. CHOLINOCEPTOR-BLOCKING DRUGS ____________________________________________ 96
CHAPTER 9. ADRENOCEPTOR AGONISTS & SYMPATHOMIMETIC DRUGS ________________________ 110
CHAPTER 10. ADRENOCEPTOR ANTAGONIST DRUGS ________________________________________ 124
SECTION 3: CARDIOVASCULAR-RENAL DRUGS _________________________ 138
CHAPTER 11. ANTIHYPERTENSIVE AGENTS _________________________________________________ 138
CHAPTER 12. VASODILATORS & THE TREATMENT OF ANGINA PECTORIS _______________________ 153
CHAPTER 13. DRUGS USED IN HEART FAILURE ______________________________________________ 167
CHAPTER 14. AGENTS USED IN CARDIAC ARRHYTHMIAS _____________________________________ 180
CHAPTER 15. DIURETIC AGENTS ___________________________________________________________ 194
SECTION 4: DRUGS WITH IMPORTANT ACTIONS ON SMOOTH MUSCLE _____ 208
CHAPTER 16. HISTAMINE, SEROTONIN, & THE ERGOT ALKALOIDS _____________________________ 208
CHAPTER 17. VASOACTIVE PEPTIDES ______________________________________________________ 218
CHAPTER 18. THE EICOSANOIDS: PROSTAGLANDINS, THROMBOXANES, LEUKOTRIENES, & RELATED
COMPOUNDS ___________________________________________________________________________ 225
CHAPTER 19. NITRIC OXIDE _______________________________________________________________ 231
CHAPTER 20. DRUGS USED IN ASTHMA & CHRONIC OBSTRUCTIVE PULMONARY DISEASE ________ 245
SECTION 5: DRUGS THAT ACT IN THE CENTRAL NERVOUS SYSTEM _______ 257
CHAPTER 21. INTRODUCTION TO THE PHARMACOLOGY OF CNS DRUGS ________________________ 257
CHAPTER 22. SEDATIVE-HYPNOTIC DRUGS _________________________________________________ 269
CHAPTER 23. THE ALCOHOLS _____________________________________________________________ 284
CHAPTER 24. ANTISEIZURE DRUGS ________________________________________________________ 297
CHAPTER 25. GENERAL ANESTHETICS _____________________________________________________ 311
CHAPTER 26. LOCAL ANESTHETICS ________________________________________________________ 325
CHAPTER 27. SKELETAL MUSCLE RELAXANTS ______________________________________________ 338
CHAPTER 28. PHARMACOLOGIC MANAGEMENT OF PARKINSONISM & OTHER MOVEMENT DISORDERS
_______________________________________________________________________________________ 352
, CHAPTER 29. ANTIPSYCHOTIC AGENTS & LITHIUM ___________________________________________ 365
CHAPTER 30. ANTIDEPRESSANT AGENTS ___________________________________________________ 379
CHAPTER 31. OPIOID AGONISTS & ANTAGONISTS ____________________________________________ 395
CHAPTER 32. DRUGS OF ABUSE ___________________________________________________________ 408
SECTION 6: DRUGS USED TO TREAT DISEASES OF THE BLOOD,
INFLAMMATION, & GOUT ____________________________________________ 419
CHAPTER 33. AGENTS USED IN CYTOPENIAS; HEMATOPOIETIC GROWTH FACTORS ______________ 419
CHAPTER 34. DRUGS USED IN DISORDERS OF COAGULATION _________________________________ 433
CHAPTER 35. AGENTS USED IN DYSLIPIDEMIA_______________________________________________ 446
CHAPTER 36. NONSTEROIDAL ANTI-INFLAMMATORY DRUGS, DISEASE-MODIFYING ANTIRHEUMATIC
DRUGS, NONOPIOID ANALGESICS, & DRUGS USED IN GOUT ___________________________________ 461
SECTION 7: ENDOCRINE DRUGS ______________________________________ 475
CHAPTER 37. HYPOTHALAMIC & PITUITARY HORMONES ______________________________________ 475
CHAPTER 38. THYROID & ANTITHYROID DRUGS _____________________________________________ 489
CHAPTER 39. ADRENOCORTICOSTEROIDS & ADRENOCORTICAL ANTAGONISTS _________________ 503
CHAPTER 40. THE GONADAL HORMONES & INHIBITORS ______________________________________ 518
CHAPTER 41. PANCREATIC HORMONES & GLUCOSE-LOWERING DRUGS ________________________ 533
CHAPTER 42. AGENTS THAT AFFECT BONE MINERAL HOMEOSTASIS ___________________________ 547
SECTION 8: CHEMOTHERAPEUTIC DRUGS _____________________________ 563
CHAPTER 43. BETA-LACTAM & OTHER CELL WALL- & MEMBRANE-ACTIVE ANTIBIOTICS __________ 563
CHAPTER 44. TETRACYCLINES, MACROLIDES, CLINDAMYCIN, CHLORAMPHENICOL,
STREPTOGRAMINS, OXAZOLIDINONES, & PLEUROMUTILINS __________________________________ 579
CHAPTER 45. AMINOGLYCOSIDES & SPECTINOMYCIN ________________________________________ 591
CHAPTER 46. SULFONAMIDES, TRIMETHOPRIM, & QUINOLONES _______________________________ 602
CHAPTER 47. ANTIMYCOBACTERIAL DRUGS ________________________________________________ 614
CHAPTER 48. ANTIFUNGAL AGENTS _______________________________________________________ 625
CHAPTER 49. ANTIVIRAL AGENTS _________________________________________________________ 639
CHAPTER 50. MISCELLANEOUS ANTIMICROBIAL AGENTS; DISINFECTANTS, ANTISEPTICS, &
STERILANTS ____________________________________________________________________________ 654
CHAPTER 51. CLINICAL USE OF ANTIMICROBIAL AGENTS _____________________________________ 670
CHAPTER 52. ANTIPROTOZOAL DRUGS _____________________________________________________ 683
CHAPTER 53. PHARMACOLOGY OF THE ANTIHELMINTHIC DRUGS ______________________________ 697
CHAPTER 54. CANCER CHEMOTHERAPY ____________________________________________________ 711
CHAPTER 55. IMMUNOPHARMACOLOGY ____________________________________________________ 727
SECTION 9: TOXICOLOGY ___________________________________________ 742
CHAPTER 56. INTRODUCTION TO TOXICOLOGY: OCCUPATIONAL & ENVIRONMENTAL_____________ 742
CHAPTER 57. HEAVY METAL INTOXICATION & CHELATORS ___________________________________ 768
CHAPTER 58. MANAGEMENT OF THE POISONED PATIENT _____________________________________ 779
, SECTION 10: SPECIAL TOPICS _______________________________________ 791
CHAPTER 59. SPECIAL ASPECTS OF PERINATAL & PEDIATRIC PHARMACOLOGY _________________ 791
CHAPTER 60. SPECIAL ASPECTS OF GERIATRIC PHARMACOLOGY _____________________________ 798
CHAPTER 61. DERMATOLOGIC PHARMACOLOGY ____________________________________________ 803
CHAPTER 62. DRUGS USED IN THE TREATMENT OF GASTROINTESTINAL DISEASES ______________ 808
CHAPTER 63. CANNABINOID DRUGS _______________________________________________________ 822
CHAPTER 64. THERAPEUTIC & TOXIC POTENTIAL OF OVER-THE-COUNTER AGENTS ______________ 834
CHAPTER 65. DIETARY SUPPLEMENTS & HERBAL MEDICATIONS ______________________________ 849
CHAPTER 66. RATIONAL PRESCRIBING & PRESCRIPTION WRITING _____________________________ 852
CHAPTER 67. IMPORTANT DRUG INTERACTIONS & THEIR MECHANISMS ________________________ 869
