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BIOLOGY 172 POST TRANSCRIPTIONAL REGULATION LECTURE NOTES 8 () SERIES MICHIGAN UNIVERSITY

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BIOLOGY 172 POST TRANSCRIPTIONAL REGULATION LECTURE NOTES 8 () SERIES MICHIGAN UNIVERSITY

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BIOLOGY 172 POST
TRANSCRIPTIONAL
REGULATION LECTURE
NOTES 8 (2025\2026)
SERIES
MICHIGAN UNIVERSITY

, = methylated CpG
Bio 172 Region of genome with a pattern of methylation
Lecture 8: Post-transcriptional Reg
Today’s Outline Right after DNA replication

• Methylation establishment
and clearing
• RNA processing
• Alternate splicing
Hemi-methylated DNA acted
• RNA stability on by DNMT
• miRNAs
• Genetic Code



PATTERN of methylation maintained!




A particular region of the genome has the following 3 genes: Gene A If you examined the gene for DNA polymerase and found that it was
codes for myosin, a critical protein in muscles; Gene B codes for a methylated+closed in a neuron and unmethylated+closed in a muscle
neuropeptide, a signaling molecule used by neurons; Gene C codes for cell, what do you think that would mean about the ability of these cell
DNA polymerase. types to divide?

Predict the methylation status (methylated or not) and chromatin status
(open or closed) for genes A and B in each of the following cell types:
neuronal cell, muscle cell, liver cell.




neuron meth, closed
muscle cell unmeth, closed
neuronal cell

muscle cell

liver cell

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