Nanomedicine Exam 3 UPDATED ACTUAL
Exam Questions and CORRECT Answers
NPs can enhance the therapeutic effects of certain drugs by - CORRECT ANSWER --
increasing circulation time
-increasing stability/compatibility
-promoting cellular internalization
-targeted delivery
NPs can enhance medical diagnosis by - CORRECT ANSWER - -improving detection
limit of target molecules or cells
-reduce the amt of sample needed
-faster
-less invasive methods
How can nanomedicine improve surgery? - CORRECT ANSWER - 1) direct
-hemostatic NPs promote healing
-nanocoating surgical blades
2) indirect
-prevent post-surgical complications
Hemostatic agents - CORRECT ANSWER - substances to help prevent/stop bleeding
blunt trauma - CORRECT ANSWER - any kind of physical trauma that occurs by impact,
injury or violence
blast trauma - CORRECT ANSWER - any kind of physical trauma that occurs from a
direct or indirect exposure to an explosion
, blunt/blast trauma cause internal bleeding; why is this so bad - CORRECT ANSWER --
blood loss after traumatic injury leading cause of death
-can bleed out quickly
-early intervention to halt bleeding can help patient get to hospital
Hemostatic NPs name & structure - CORRECT ANSWER - GRGDS-NPs
structure:
-core: polymer PLGA attached to poly-e-lysine= (PLGA-PLL)
-tails: PEG
-on end of tails: peptide sequence RGB
-size abt 400nm
2 common ways to prepare PLGAs - CORRECT ANSWER - 1) single emulsion: PLGA &
hydrophobic drug in nonpolar organic solvent added to aqueous stabilizer solution
2)double emulsion: PLGA solution added to aqueous hydrophilic drug solution subject to heat
and after first emulsion it is poured in aqueous stabilizer solution as second emulsion
Blast trauma animal model - CORRECT ANSWER - 1) induce injury ((1)apply weight
over certain distance or (2) preform laparotomy)
2) animal die
3) NP (GRGDS-NPs) administered to animals
How do the hemostatic NPs work (GRGS-NPs) - CORRECT ANSWER - enhance the
aggregation of platelets to stop bleeding
-GRGDS-NPs (hemostatic NPs) promote platelet aggregation by binding to the glycoprotein
2b/3a receptors on the surface of platelets to stabilize the whole clot
How does clotting work - CORRECT ANSWER - -clotting is the process by which blood
changes from a liquid to a gel
Exam Questions and CORRECT Answers
NPs can enhance the therapeutic effects of certain drugs by - CORRECT ANSWER --
increasing circulation time
-increasing stability/compatibility
-promoting cellular internalization
-targeted delivery
NPs can enhance medical diagnosis by - CORRECT ANSWER - -improving detection
limit of target molecules or cells
-reduce the amt of sample needed
-faster
-less invasive methods
How can nanomedicine improve surgery? - CORRECT ANSWER - 1) direct
-hemostatic NPs promote healing
-nanocoating surgical blades
2) indirect
-prevent post-surgical complications
Hemostatic agents - CORRECT ANSWER - substances to help prevent/stop bleeding
blunt trauma - CORRECT ANSWER - any kind of physical trauma that occurs by impact,
injury or violence
blast trauma - CORRECT ANSWER - any kind of physical trauma that occurs from a
direct or indirect exposure to an explosion
, blunt/blast trauma cause internal bleeding; why is this so bad - CORRECT ANSWER --
blood loss after traumatic injury leading cause of death
-can bleed out quickly
-early intervention to halt bleeding can help patient get to hospital
Hemostatic NPs name & structure - CORRECT ANSWER - GRGDS-NPs
structure:
-core: polymer PLGA attached to poly-e-lysine= (PLGA-PLL)
-tails: PEG
-on end of tails: peptide sequence RGB
-size abt 400nm
2 common ways to prepare PLGAs - CORRECT ANSWER - 1) single emulsion: PLGA &
hydrophobic drug in nonpolar organic solvent added to aqueous stabilizer solution
2)double emulsion: PLGA solution added to aqueous hydrophilic drug solution subject to heat
and after first emulsion it is poured in aqueous stabilizer solution as second emulsion
Blast trauma animal model - CORRECT ANSWER - 1) induce injury ((1)apply weight
over certain distance or (2) preform laparotomy)
2) animal die
3) NP (GRGDS-NPs) administered to animals
How do the hemostatic NPs work (GRGS-NPs) - CORRECT ANSWER - enhance the
aggregation of platelets to stop bleeding
-GRGDS-NPs (hemostatic NPs) promote platelet aggregation by binding to the glycoprotein
2b/3a receptors on the surface of platelets to stabilize the whole clot
How does clotting work - CORRECT ANSWER - -clotting is the process by which blood
changes from a liquid to a gel
