Nanomedicine Test 5 UPDATED ACTUAL
Exam Questions and CORRECT Answers
Preclinical - in vitro and vivo studies, animal models, safety; Phase I - 10 participants, humans,
understand effects; Phase 2 - 20-50, humans, safety and efficacy; Phase 3 - 100-200, humans,
confirm benefits and safety, FDA approval after this; Phase 4 - 200+, humans, evaluate long term
effects - CORRECT ANSWER - what are the phases of a clinical trial?
in vivo and vitro, animal models, research and safety - CORRECT ANSWER - What set of
experiments involves the preclinical phase?
traditional - weakened or inactivated pathogens, purified or recombinantly produced viral
proteins with adjuvants; mRNA - no oncogenic potential, faster to make, no pathogen growth,
flexible stockpiling approach, stable for decades - CORRECT ANSWER - Describe the
difference between traditional vaccines and mRNA based vaccines.
No pathogen growth needed, no adjuvant needed - CORRECT ANSWER - Explain why
mRNA vaccines can be developed faster than traditional ones.
mediates receptor recognition and membrane fusion - how the virus gets into the cell and is the
primary target for the immune response - CORRECT ANSWER - Why is the coronavirus
Spike glycoprotein has been selected as a vaccine target?
heat, RNAses - CORRECT ANSWER - What could trigger premature degradation of
mRNA?
encapsulate them, protect them in a shell that the RNAse can't get through - CORRECT
ANSWER - Explain why LNPs can prevent degradation of mRNA
different assembly process, LNPs use cationic lipids and structural lipids, LNPs have multiple
inside micelles - CORRECT ANSWER - What are the main structural difference between
liposomes and LNPs?
Exam Questions and CORRECT Answers
Preclinical - in vitro and vivo studies, animal models, safety; Phase I - 10 participants, humans,
understand effects; Phase 2 - 20-50, humans, safety and efficacy; Phase 3 - 100-200, humans,
confirm benefits and safety, FDA approval after this; Phase 4 - 200+, humans, evaluate long term
effects - CORRECT ANSWER - what are the phases of a clinical trial?
in vivo and vitro, animal models, research and safety - CORRECT ANSWER - What set of
experiments involves the preclinical phase?
traditional - weakened or inactivated pathogens, purified or recombinantly produced viral
proteins with adjuvants; mRNA - no oncogenic potential, faster to make, no pathogen growth,
flexible stockpiling approach, stable for decades - CORRECT ANSWER - Describe the
difference between traditional vaccines and mRNA based vaccines.
No pathogen growth needed, no adjuvant needed - CORRECT ANSWER - Explain why
mRNA vaccines can be developed faster than traditional ones.
mediates receptor recognition and membrane fusion - how the virus gets into the cell and is the
primary target for the immune response - CORRECT ANSWER - Why is the coronavirus
Spike glycoprotein has been selected as a vaccine target?
heat, RNAses - CORRECT ANSWER - What could trigger premature degradation of
mRNA?
encapsulate them, protect them in a shell that the RNAse can't get through - CORRECT
ANSWER - Explain why LNPs can prevent degradation of mRNA
different assembly process, LNPs use cationic lipids and structural lipids, LNPs have multiple
inside micelles - CORRECT ANSWER - What are the main structural difference between
liposomes and LNPs?
