Nanomedicine Midterm Prep UPDATED
ACTUAL Exam Questions and CORRECT
Answers
Define nanomedicine and list at least three different applications of nanomedicine. - CORRECT
ANSWER - Nanomedicine is the use of nano-biotechnology in medicine. Different
applications of nanomedicine include imaging agents and diagnostics, real-time assessment to
accelerate clinical translation, multifunctional targeted devices, monitoring predictive molecular
changes, and research enablers like chip-based nano-labs.
Name four examples of FDA-approved nanotechnology-based products, and explain one
advantage of using nanocarriers in drug delivery. - CORRECT ANSWER - Four examples
of FDA-approved nanotechnology-based products are Abraxane, Doxil, Feraheme, and
Mycamine. An advantage of using nanocarriers in drug delivery is the enhanced targeting and
delivery of therapeutic agents to specific cells or tissues, reducing off-target effects and
improving treatment efficacy.
What physicochemical characteristics influence the toxicity and biodistribution of
nanoconstructs? Provide examples of physical and chemical characteristics. - CORRECT
ANSWER - Physicochemical characteristics influencing nanoconstructs toxicity and
biodistribution include physical characteristics like size, surface area, and shape, and chemical
characteristics like charge, hydrophobicity/hydrophilicity, and surface chemistry. For instance, a
smaller size and a positive charge may increase cellular uptake, while hydrophobicity can affect
solubility and toxicity.
Summarize the findings reported in the research article "Multivalent HER2-binding polymer
conjugates facilitate rapid endocytosis and enhance intracellular drug delivery." - CORRECT
ANSWER - The research co-opts crosslinking-mediated internalization for efficient
intracellular delivery of an anticancer nanomedicine, particularly an HPMA copolymer-based
drug delivery system. The study synthesized and characterized HPMA copolymers-affibody
conjugates, demonstrating that higher valence conjugates enhanced intracellular drug delivery
and cytotoxicity against HER2-positive cells.
What polymerization technique was used in the synthesis of polymer conjugates in the
mentioned article, and why is it relevant for drug delivery systems? - CORRECT
ACTUAL Exam Questions and CORRECT
Answers
Define nanomedicine and list at least three different applications of nanomedicine. - CORRECT
ANSWER - Nanomedicine is the use of nano-biotechnology in medicine. Different
applications of nanomedicine include imaging agents and diagnostics, real-time assessment to
accelerate clinical translation, multifunctional targeted devices, monitoring predictive molecular
changes, and research enablers like chip-based nano-labs.
Name four examples of FDA-approved nanotechnology-based products, and explain one
advantage of using nanocarriers in drug delivery. - CORRECT ANSWER - Four examples
of FDA-approved nanotechnology-based products are Abraxane, Doxil, Feraheme, and
Mycamine. An advantage of using nanocarriers in drug delivery is the enhanced targeting and
delivery of therapeutic agents to specific cells or tissues, reducing off-target effects and
improving treatment efficacy.
What physicochemical characteristics influence the toxicity and biodistribution of
nanoconstructs? Provide examples of physical and chemical characteristics. - CORRECT
ANSWER - Physicochemical characteristics influencing nanoconstructs toxicity and
biodistribution include physical characteristics like size, surface area, and shape, and chemical
characteristics like charge, hydrophobicity/hydrophilicity, and surface chemistry. For instance, a
smaller size and a positive charge may increase cellular uptake, while hydrophobicity can affect
solubility and toxicity.
Summarize the findings reported in the research article "Multivalent HER2-binding polymer
conjugates facilitate rapid endocytosis and enhance intracellular drug delivery." - CORRECT
ANSWER - The research co-opts crosslinking-mediated internalization for efficient
intracellular delivery of an anticancer nanomedicine, particularly an HPMA copolymer-based
drug delivery system. The study synthesized and characterized HPMA copolymers-affibody
conjugates, demonstrating that higher valence conjugates enhanced intracellular drug delivery
and cytotoxicity against HER2-positive cells.
What polymerization technique was used in the synthesis of polymer conjugates in the
mentioned article, and why is it relevant for drug delivery systems? - CORRECT
