Cancer Treatment and Nanomedicine
UPDATED ACTUAL Exam Questions and
CORRECT Answers
Cancer - CORRECT ANSWER - Leading cause of death worldwide
Cancer treatment modalities - CORRECT ANSWER - Surgery, radiation, chemotherapy
Chemotherapy - CORRECT ANSWER - Not highly efficient in killing tumor cells
Pharmacokinetics - CORRECT ANSWER - Study of drug movement within the body
Chemotherapy drugs - CORRECT ANSWER - Poor pharmacokinetics and systemic
toxicities
Advantages of nanomedicine - CORRECT ANSWER - Longer circulation time, reduced
side effects, controlled and sustained drug release
EPR effect - CORRECT ANSWER - Enhanced permeability and retention in tumors
Liposome - CORRECT ANSWER - Composed of a phospholipid bilayer
Liposome encapsulation - CORRECT ANSWER - Can encapsulate both hydrophobic and
hydrophilic drugs
Polymeric micelle - CORRECT ANSWER - Made up of biosurfactant with hydrophobic
tail
, Currently approved nanocarriers - CORRECT ANSWER - Use biologically functional
materials
Polyethylene glycol (PEG) - CORRECT ANSWER - Not hydrophobic
PEGylation - CORRECT ANSWER - Increases drug size, improves solubility, avoids
recognition/binding of mononuclear phagocyte system
Paclitaxel (PTX) - CORRECT ANSWER - Natural product chemodrug
Taxol - CORRECT ANSWER - Formulated in 50% cremophor EL and 50% ethanol
Abraxane - CORRECT ANSWER - Albumin-bound paclitaxel nanoformulation
Embelin (EB) - CORRECT ANSWER - Hydrophobic and natural product anticancer drug
PEG-EB2 - CORRECT ANSWER - Increases water solubility of EB and self-assembles
into liposome
Micelles - CORRECT ANSWER - Can be prepared via solvent evaporation method
MTT assay - CORRECT ANSWER - Used to determine cell viability and metabolic
activity
PTX-loaded PEG-EB2 - CORRECT ANSWER - Has slower and sustained PTX release
compared to Taxol
PTX-loaded PEG-EB2 - CORRECT ANSWER - Increases maximum tolerated dose
compared to Taxol
UPDATED ACTUAL Exam Questions and
CORRECT Answers
Cancer - CORRECT ANSWER - Leading cause of death worldwide
Cancer treatment modalities - CORRECT ANSWER - Surgery, radiation, chemotherapy
Chemotherapy - CORRECT ANSWER - Not highly efficient in killing tumor cells
Pharmacokinetics - CORRECT ANSWER - Study of drug movement within the body
Chemotherapy drugs - CORRECT ANSWER - Poor pharmacokinetics and systemic
toxicities
Advantages of nanomedicine - CORRECT ANSWER - Longer circulation time, reduced
side effects, controlled and sustained drug release
EPR effect - CORRECT ANSWER - Enhanced permeability and retention in tumors
Liposome - CORRECT ANSWER - Composed of a phospholipid bilayer
Liposome encapsulation - CORRECT ANSWER - Can encapsulate both hydrophobic and
hydrophilic drugs
Polymeric micelle - CORRECT ANSWER - Made up of biosurfactant with hydrophobic
tail
, Currently approved nanocarriers - CORRECT ANSWER - Use biologically functional
materials
Polyethylene glycol (PEG) - CORRECT ANSWER - Not hydrophobic
PEGylation - CORRECT ANSWER - Increases drug size, improves solubility, avoids
recognition/binding of mononuclear phagocyte system
Paclitaxel (PTX) - CORRECT ANSWER - Natural product chemodrug
Taxol - CORRECT ANSWER - Formulated in 50% cremophor EL and 50% ethanol
Abraxane - CORRECT ANSWER - Albumin-bound paclitaxel nanoformulation
Embelin (EB) - CORRECT ANSWER - Hydrophobic and natural product anticancer drug
PEG-EB2 - CORRECT ANSWER - Increases water solubility of EB and self-assembles
into liposome
Micelles - CORRECT ANSWER - Can be prepared via solvent evaporation method
MTT assay - CORRECT ANSWER - Used to determine cell viability and metabolic
activity
PTX-loaded PEG-EB2 - CORRECT ANSWER - Has slower and sustained PTX release
compared to Taxol
PTX-loaded PEG-EB2 - CORRECT ANSWER - Increases maximum tolerated dose
compared to Taxol
