BIO 225 (Microbiology) CHAPTER
OUTLINE FOR SKIN AND EYE INFECTIOUS
DISEASES FROM, MICROBIOLOGY
FUNDAMENTALS A CLINICAL APPROACH,
COWAN SMITH GREENE VILLE TECHNICAL
COLLEGE.
, Chapter 16: Infectious Diseases of the Skin and Eyes
Review the Structure and Function of Skin (Fig 16.1)
Defenses of the Skin
Continuous shedding
Antimicrobial peptides -these are positively charged chemicals that act by
disrupting the negatively charged membranes of bacteria.
Sebum creates a low pH
Sweat gives skin a high salt concentration
Lysozyme is an enzyme found in sweat (and tears and saliva) that
specifically breaks down peptidoglycan, a unique component of bacterial cell
walls.
Normal Biota of the Skin
Sparsely distributed over dry, flat areas of the skin
Where is biota most abundant on skin? Moist areas and skin folds
Also found in hair follicles and glandular ducts
Discoveries of the Human Microbiome Project:
• Is skin biota diverse or limited? diverse
• Is skin biota limited to epidermis? No, also includes dermis and
subcutaneous skin layers
• An individual’s microbiota remains relatively constant over time.
• Some microbiome members are associated with the loss of collagen
MRSA- Disease Table 16.1
Methicillin-Resistant Staphylococcus aureus
Some are resistant to multiple antibiotics
OUTLINE FOR SKIN AND EYE INFECTIOUS
DISEASES FROM, MICROBIOLOGY
FUNDAMENTALS A CLINICAL APPROACH,
COWAN SMITH GREENE VILLE TECHNICAL
COLLEGE.
, Chapter 16: Infectious Diseases of the Skin and Eyes
Review the Structure and Function of Skin (Fig 16.1)
Defenses of the Skin
Continuous shedding
Antimicrobial peptides -these are positively charged chemicals that act by
disrupting the negatively charged membranes of bacteria.
Sebum creates a low pH
Sweat gives skin a high salt concentration
Lysozyme is an enzyme found in sweat (and tears and saliva) that
specifically breaks down peptidoglycan, a unique component of bacterial cell
walls.
Normal Biota of the Skin
Sparsely distributed over dry, flat areas of the skin
Where is biota most abundant on skin? Moist areas and skin folds
Also found in hair follicles and glandular ducts
Discoveries of the Human Microbiome Project:
• Is skin biota diverse or limited? diverse
• Is skin biota limited to epidermis? No, also includes dermis and
subcutaneous skin layers
• An individual’s microbiota remains relatively constant over time.
• Some microbiome members are associated with the loss of collagen
MRSA- Disease Table 16.1
Methicillin-Resistant Staphylococcus aureus
Some are resistant to multiple antibiotics
