BIO 172 EXAM QUESTIONS WITH
100% CORRECT ANSWERS
Which best describes E2F?
A: E2F is a transcription factor which regulates transcription of M phase proteins
B: E2F is a transcription factor which regulates transcription of Rb
C: E2F is a transcription factor which regulates transcription of p53
D: E2F is a transcription factor which regulates transcription of S phase proteins -
Answer-D: E2F is a transcription factor which regulates transcription of S phase proteins
Which one of the following is NOT an activity attributed to the checkpoint regulated by
the G1/S cyclin-CDK complex in mammals?
A: Excess p53 in the nucleus increases expression of an inhibitor of CDK activity.
B: Protein complexes involved in DNA replication are activated.
C: Radiation damage to DNA results in the inhibition of the G1/S cyclin-CDK complex
and blocks progression of the cell cycle to S phase.
D: Radiation damage to DNA activates phosphorylation of a p53 protein, preventing its
export from the nucleus.
E: Histone expression is inhibited, allowing replication to proceed. - Answer-E: Histone
expression is inhibited, allowing replication to proceed.
When nutrients are suboptimal for cell growth and division, the cell cycle arrests. At
which stage of the cell cycle/checkpoint would you predict this arrest to occur?
A: M checkpoint
B: G2 checkpoint
C: It is not possible to answer with the information given.
D: G1 checkpoint
E: G1, G2, and the M checkpoints - Answer-D: G1 checkpoint
Fill in the blanks: _______________ promote cancer and __________________ block
specific steps in the development of cancer.
A: tumor suppressors, tumor suppressors
B: oncogenes, proto-oncogenes
C: oncogenes, tumor suppressors
D: tumor suppressors, oncogenes - Answer-C: oncogenes, tumor suppressors
What is the type of protein found on the surface of metastatic cancer cells that interacts
with the basal lamina?
A: cyclins
B: receptor tyrosine kinases
, C: Cadhesins
D: Integrins - Answer-D: Integrins
What is a common feature between benign and malignant tumors?
A: Invades other tissues
B: Able to cross the basal lamina
C: Promotes the growth of blood vessels
D: Has defects in the regulation of cell division
E: Able to enter the circulatory system - Answer-D: Has defects in the regulation of cell
division
Why is it rare for a point mutation to convert a proto-oncogene into an oncogene?
A: Point mutations do not occur as frequently as chromosomal deletions.
B: Point mutations generally do not occur in the protein-coding region.
C: Point mutations do not occur as frequently as chromosomal rearrangements.
D: It is unusual for one amino acid change to cause a protein to be more active. -
Answer-D: It is unusual for one amino acid change to cause a protein to be more active.
Which of the following might be used to successfully treat cancer?
A: Increasing the expression of the angiogenesis promoting factor VEGF
B: A drug which activates oncogenes
C: Blocking the ability of integrins to interact with the basal lamina
D: Inhibiting apoptosis
E: Increasing the activity of the enzyme telomerase - Answer-C: Blocking the ability of
integrins to interact with the basal lamina
Which of the following is NOT a function performed by tumor suppressor genes?
A: Inhibiting apoptosis
B: Repairing mutations
C: Inhibiting the action of oncogenes
D: Enforcing a cell cycle checkpoint
E: Slowing cell division - Answer-A: Inhibiting apoptosis
This germ layer will give rise to the lining of the digestive track and lung, as well as liver
and pancreas.
A: mesoderm
B: ectoderm
C: endoderm - Answer-C: endoderm
Which of the following is not a true difference between DNA replication and transcription
in eukaryotes?
A: Transcription uses ribonucleotides; replication only uses deoxyribonucleotides.
B: Transcription relies on RNA polymerase to unwind the DNA helix; replication relies
on helicase.
C: Transcription of an entire gene doesn't need topoisomerase; replication of a
complete genome needs topoisomerase.
100% CORRECT ANSWERS
Which best describes E2F?
A: E2F is a transcription factor which regulates transcription of M phase proteins
B: E2F is a transcription factor which regulates transcription of Rb
C: E2F is a transcription factor which regulates transcription of p53
D: E2F is a transcription factor which regulates transcription of S phase proteins -
Answer-D: E2F is a transcription factor which regulates transcription of S phase proteins
Which one of the following is NOT an activity attributed to the checkpoint regulated by
the G1/S cyclin-CDK complex in mammals?
A: Excess p53 in the nucleus increases expression of an inhibitor of CDK activity.
B: Protein complexes involved in DNA replication are activated.
C: Radiation damage to DNA results in the inhibition of the G1/S cyclin-CDK complex
and blocks progression of the cell cycle to S phase.
D: Radiation damage to DNA activates phosphorylation of a p53 protein, preventing its
export from the nucleus.
E: Histone expression is inhibited, allowing replication to proceed. - Answer-E: Histone
expression is inhibited, allowing replication to proceed.
When nutrients are suboptimal for cell growth and division, the cell cycle arrests. At
which stage of the cell cycle/checkpoint would you predict this arrest to occur?
A: M checkpoint
B: G2 checkpoint
C: It is not possible to answer with the information given.
D: G1 checkpoint
E: G1, G2, and the M checkpoints - Answer-D: G1 checkpoint
Fill in the blanks: _______________ promote cancer and __________________ block
specific steps in the development of cancer.
A: tumor suppressors, tumor suppressors
B: oncogenes, proto-oncogenes
C: oncogenes, tumor suppressors
D: tumor suppressors, oncogenes - Answer-C: oncogenes, tumor suppressors
What is the type of protein found on the surface of metastatic cancer cells that interacts
with the basal lamina?
A: cyclins
B: receptor tyrosine kinases
, C: Cadhesins
D: Integrins - Answer-D: Integrins
What is a common feature between benign and malignant tumors?
A: Invades other tissues
B: Able to cross the basal lamina
C: Promotes the growth of blood vessels
D: Has defects in the regulation of cell division
E: Able to enter the circulatory system - Answer-D: Has defects in the regulation of cell
division
Why is it rare for a point mutation to convert a proto-oncogene into an oncogene?
A: Point mutations do not occur as frequently as chromosomal deletions.
B: Point mutations generally do not occur in the protein-coding region.
C: Point mutations do not occur as frequently as chromosomal rearrangements.
D: It is unusual for one amino acid change to cause a protein to be more active. -
Answer-D: It is unusual for one amino acid change to cause a protein to be more active.
Which of the following might be used to successfully treat cancer?
A: Increasing the expression of the angiogenesis promoting factor VEGF
B: A drug which activates oncogenes
C: Blocking the ability of integrins to interact with the basal lamina
D: Inhibiting apoptosis
E: Increasing the activity of the enzyme telomerase - Answer-C: Blocking the ability of
integrins to interact with the basal lamina
Which of the following is NOT a function performed by tumor suppressor genes?
A: Inhibiting apoptosis
B: Repairing mutations
C: Inhibiting the action of oncogenes
D: Enforcing a cell cycle checkpoint
E: Slowing cell division - Answer-A: Inhibiting apoptosis
This germ layer will give rise to the lining of the digestive track and lung, as well as liver
and pancreas.
A: mesoderm
B: ectoderm
C: endoderm - Answer-C: endoderm
Which of the following is not a true difference between DNA replication and transcription
in eukaryotes?
A: Transcription uses ribonucleotides; replication only uses deoxyribonucleotides.
B: Transcription relies on RNA polymerase to unwind the DNA helix; replication relies
on helicase.
C: Transcription of an entire gene doesn't need topoisomerase; replication of a
complete genome needs topoisomerase.
