ONS Chemotherapy Administration
LATEST UPDATED 2025/2026 Exam
WITH COMPLETE Questions with
correct Answers 100% GRADED AT
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1. Alkylating Agents - ANSWER ✔ synthetic chemicals that cause
breaks in DNA strands
Non-specific cell cycle
Examples: Busulfan, Cisplatin, Carboplatin, Cyclophosphamide,
Ifosfamide, Melphalan, Oxaliplatin
2. Common side effect to remember about Cyclophosphamide
(Alkylating Agent) - ANSWER ✔ This drug is known to cause
hemorrhagic cystitis (inflammation of the bladder), which might reveal
itself as dysuria, hematuria, and hemorrhage. One important measure to
prevent this is adequate hydration prior to, during, and after treatment.
While at home, be sure to drink 2-3 L per day, and be sure to empty your
bladder frequently. Often, mesna is given with IV fluids to prevent
hemorrhagic cystitis.
3. Common alkylating agents - ANSWER ✔ Alkylating agents
function by causing a break in the DNA helix strand, causing
interference with DNA replication, which results in cell death.
, Alkylating agents are subcategorized into several groups. The most
common alkylating agents, known as nitrogen mustards, typically
include the following:
Cyclophosphamide (Cytoxan®)
Ifosfamide (Ifex®)
Bendamustine (Treanda®)
Platinum-based chemotherapy agents act similarly to alkylating agents,
but they do not possess an alkyl group molecule to attach to and destroy
DNA. Despite this, they are often termed alkylating agents, or
alkylating-like agents. Common platinum-based drugs include the
following:
Cisplatin (Platinol®)
Carboplatin (Paraplatin®)
However, depending on the type of patients that you see, other
alkylating agents may be more common in your workplace. A third
subcategory of alkylating agents is known as the nitrosoureas.
4. Alkylating Agents:
Dose limiting? Side effects? - ANSWER ✔ These agents have many
dose-limiting toxiciites that need to be monitored closely, including the
following:
Bone marrow suppression, which can put a patient at risk for infection
Gastrointestinal (GI) toxicities, particularly nausea, vomiting, and
diarrhea
Renal toxicities
Hepatotoxicity
Pulmonary fibrosis
Hypersensitivities
5. Key points to remember about the alkylating agents and nitrosoureas:
- ANSWER ✔ - Hypersensitivity may occur with late doses of
carboplatin.
LATEST UPDATED 2025/2026 Exam
WITH COMPLETE Questions with
correct Answers 100% GRADED AT
A+ SCORE GUARANTEED PASS!!
1. Alkylating Agents - ANSWER ✔ synthetic chemicals that cause
breaks in DNA strands
Non-specific cell cycle
Examples: Busulfan, Cisplatin, Carboplatin, Cyclophosphamide,
Ifosfamide, Melphalan, Oxaliplatin
2. Common side effect to remember about Cyclophosphamide
(Alkylating Agent) - ANSWER ✔ This drug is known to cause
hemorrhagic cystitis (inflammation of the bladder), which might reveal
itself as dysuria, hematuria, and hemorrhage. One important measure to
prevent this is adequate hydration prior to, during, and after treatment.
While at home, be sure to drink 2-3 L per day, and be sure to empty your
bladder frequently. Often, mesna is given with IV fluids to prevent
hemorrhagic cystitis.
3. Common alkylating agents - ANSWER ✔ Alkylating agents
function by causing a break in the DNA helix strand, causing
interference with DNA replication, which results in cell death.
, Alkylating agents are subcategorized into several groups. The most
common alkylating agents, known as nitrogen mustards, typically
include the following:
Cyclophosphamide (Cytoxan®)
Ifosfamide (Ifex®)
Bendamustine (Treanda®)
Platinum-based chemotherapy agents act similarly to alkylating agents,
but they do not possess an alkyl group molecule to attach to and destroy
DNA. Despite this, they are often termed alkylating agents, or
alkylating-like agents. Common platinum-based drugs include the
following:
Cisplatin (Platinol®)
Carboplatin (Paraplatin®)
However, depending on the type of patients that you see, other
alkylating agents may be more common in your workplace. A third
subcategory of alkylating agents is known as the nitrosoureas.
4. Alkylating Agents:
Dose limiting? Side effects? - ANSWER ✔ These agents have many
dose-limiting toxiciites that need to be monitored closely, including the
following:
Bone marrow suppression, which can put a patient at risk for infection
Gastrointestinal (GI) toxicities, particularly nausea, vomiting, and
diarrhea
Renal toxicities
Hepatotoxicity
Pulmonary fibrosis
Hypersensitivities
5. Key points to remember about the alkylating agents and nitrosoureas:
- ANSWER ✔ - Hypersensitivity may occur with late doses of
carboplatin.
