x x
Evolutionary xAnalysis x5th xEdition xby xHerron xJon; xFreeman xScott xISBN x9780321998378
xChapter x1-20
Chapter x 1 A x Case x for x Evolutionary x Thinking: x Understanding x HIV
1) In x which x of x the x following x regions x has x AIDS x killed x the x largest x number x of x individuals?
A) India
B) Sub-Saharan x Africa
C) United x States
D) China
E) United xKingdom
xAnswer: x B
xSection: x 1.1
Skill: Knowledge/Comprehension
2) The x HIV x virus x contains x all x of x the x following x components x except x .
A) integrase
B) double-stranded x RNA
C) single-stranded x RNA
D) reverse x transcriptase
E) protease
xAnswer:
x B xSection:
1.1
Skill: Knowledge/Comprehension
3) The x acronym x HIV x stands x for x which x of x the x following?
A) human x intercellular x virus
B) human x immune x virus
C) human x immunodeficiency x virus
D) human x immunity x virus
E) human ximmunodeficiency xvector
xAnswer: x C
Section: 1.1
Skill: Knowledge/Comprehension
4) Which x of x the x following x enzymes x is x responsible x for x transcribing x viral x RNA x into x DNA?
A) RNA x polymerase
B) reverse x transcriptase
C) DNA x polymerase
D) reverse x integrase
E) RNA xduplicase
xAnswer: x B
xSection: x 1.1
Skill: Knowledge/Comprehension
1
Copyright x © x 2014 x Pearson
x Education,
,5) The x proteins x that x enable x the x HIV x virus x to x bind x to x cells x are x typically xCD4 x and
x CCR5. x On xwhat x type x of x cells x are x these x proteins x typically x observed?
A) plasma x cells
B) dendritic x cells
C) effector x helper x T x cells
D) memory x helper x T x cells
E) both xC xand
xD xAnswer:
x E xSection:
x 1.1
Skill: Knowledge/Comprehension
6) The xAIDS x phase xof x HIV x infection x begins x when x the x concentration x of xCD4 x T x cells x in
x the xblood xdrops xbelow xwhat xconcentration?
A) 2,000 x cells x per x cubic x millimeter
B) 1,000 x cells x per x cubic x millimeter
C) 500 x cells x per x cubic x millimeter
D) 200 x cells x per x cubic x millimeter
E) No xCD4 xT xcells xare
xobserved. xAnswer: xD
xSection: x 1.1
Skill: x x Knowledge/Comprehension
7) Which x of x the x following x drug x categories x are x used x to x treat x HIV x infections?
A) integrase x inhibitors
B) protease x inhibitors
C) reverse x transcriptase x inhibitors
D) DNAse x inhibitors
E) fusion xinhibitors
xAnswer: x D
xSection: x 1.2
Skill: Knowledge/Comprehension
8) Coreceptor x inhibitors x block x HIV x infection x by x preventing x which x of x the x following?
A) binding x of x the x HIV x virion x onto x the x plasma x membrane
B) binding x of x the x HIV x virion x onto x the x CCR5 x receptor
C) binding x of x the x HIV x virion x onto x the x gp120 x protein
D) degrading x the x coreceptor x so x the x virion x cannot x attach
E) binding xof xthe xHIV xvirion xonto xthe xCD4
xreceptor xAnswer: x B
Section: 1.2
Skill: Application/Analysis
9) What x is x the x effect x of x the x ∆32 x allele x of x CCR5 x on x HIV x binding?
A) appears x on x the x surface x of x CD4 x T x cells, x but x the x HIV x virion x is x unable x to x infect x the x host
x cell
B) does x not x appear x on x the x surface x of x CD4 x T x cells
2
Copyright x © x 2014 x Pearson
x Education,
,C) appears x on x the x surface x of x the x CD4 x T x cells x and x inactivates x the x virion x upon x binding
D) interferes x with x binding x of x the x virion x to x the x CD4 x receptor x protein
3
Copyright x © x 2014 x Pearson
x Education,
, E) appears x on x the x surface x of x the x CD4 x T x cells x and x causes x the x virion x to x lyse
x upon xbinding xAnswer: x B
Section: 1.3
Skill: Application/Analysis
10) The x ∆32 x allele x of x CCR5 x is x found x at x the xhighest x frequency xin x which x of
xthe xfollowing xpopulations?
A) Africans
B) Japanese
C) North x Americans
D) Europeans
E) South xAmericans
xAnswer: x D
xSection: x 1.3
Skill: Knowledge/Comprehension
11) HIV-1 xis xbelieved xto xhave xbeen xtransmitted xto xhumans xfrom xwhich xof xthe
x following xorganisms?
A) gorillas
B) sooty x mangabeys
C) African x green x monkeys
D) chimpanzees
E) baboons
xAnswer:
x D xSection:
1.4
Skill: Knowledge/Comprehension
12) HIV-1 x Group x M xis xresponsible x for x95% xof x human x infections. x When xis xit x estimated
xthat xHIV-1 xGroup xM xwas xtransferred xto xhumans?
A) 1980
B) 1960
C) 1930
D) 1995
E) 1900
Answer: x C
xSection:
1.4
Skill: Knowledge/Comprehension
13) Antibodies xand xkiller xT xcells x recognize xHIV xor xHIV-infected xcells x by xbinding xto xshort
x pieces x of x viral x proteins x displayed x on x the x virus x or x the x infected x host x cell. x These x short
x pieces xof xviral xproteins xare xcalled x .
A) coat x proteins
B) virosomes
C) proteosomes
D) epitopes
4
Copyright x © x 2014 x Pearson
x Education,