q q
Evolutionary qAnalysis q5th qEdition qby qHerron qJon; qFreeman qScott qISBN q9780321998378
qChapter q1-20
Chapter q1 q q A qCase qfor qEvolutionary qThinking: qUnderstanding qHIV
1) In qwhich qof qthe qfollowing qregions qhas qAIDS qkilled qthe qlargest qnumber qof qindividuals?
A) India
B) Sub-Saharan qAfrica
C) United qStates
D) China
E) United qKingdom
qAnswer: q B
q Section: q 1.1
Skill: q Knowledge/Comprehension
2) The qHIV qvirus qcontains qall qof qthe qfollowing qcomponents qexcept q .
A) integrase
B) double-stranded qRNA
C) single-stranded qRNA
D) reverse qtranscriptase
E) protease
qAnswer: qB
qSection:
q 1.1
Skill: q Knowledge/Comprehension
3) The qacronym qHIV qstands qfor qwhich qof qthe qfollowing?
A) human qintercellular qvirus
B) human qimmune qvirus
C) human qimmunodeficiency qvirus
D) human qimmunity qvirus
E) human qimmunodeficiency qvector
qAnswer: q C
Section: q 1.1
Skill: q Knowledge/Comprehension
4) Which qof qthe qfollowing qenzymes qis qresponsible qfor qtranscribing qviral qRNA qinto qDNA?
A) RNA qpolymerase
B) reverse qtranscriptase
C) DNA qpolymerase
D) reverse qintegrase
E) RNA qduplicase
qAnswer: q B
qSection: q 1.1
Skill: q Knowledge/Comprehension
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qInc.
,5) The qproteins qthat qenable qthe qHIV qvirus qto qbind qto qcells qare qtypically qCD4 qand qCCR5. qOn
qwhat qtype qof qcells qare qthese qproteins qtypically qobserved?
A) plasma qcells
B) dendritic qcells
C) effector qhelper qT qcells
D) memory qhelper qT qcells
E) both qC qand
qD qAnswer: q E
qSection: q 1.1
Skill: q Knowledge/Comprehension
6) The qAIDS qphase qof qHIV qinfection qbegins qwhen qthe qconcentration qof qCD4 qT qcells qin qthe
qblood qdrops qbelow qwhat qconcentration?
A) 2,000 qcells qper qcubic qmillimeter
B) 1,000 qcells qper qcubic qmillimeter
C) 500 qcells qper qcubic qmillimeter
D) 200 qcells qper qcubic qmillimeter
E) No qCD4 qT qcells qare
qobserved. qAnswer: q D
Section: q 1.1
Skill: q Knowledge/Comprehension
7) Which qof qthe qfollowing qdrug qcategories qare qused qto qtreat qHIV qinfections?
A) integrase qinhibitors
B) protease qinhibitors
C) reverse qtranscriptase qinhibitors
D) DNAse qinhibitors
E) fusion qinhibitors
qAnswer: q D
qSection: q 1.2
Skill: q Knowledge/Comprehension
8) Coreceptor qinhibitors qblock qHIV qinfection qby qpreventing qwhich qof qthe qfollowing?
A) binding qof qthe qHIV qvirion qonto qthe qplasma qmembrane
B) binding qof qthe qHIV qvirion qonto qthe qCCR5 qreceptor
C) binding qof qthe qHIV qvirion qonto qthe qgp120 qprotein
D) degrading qthe qcoreceptor qso qthe qvirion qcannot qattach
E) binding qof qthe qHIV qvirion qonto qthe qCD4
qreceptor qAnswer: q B
Section: q 1.2
Skill: q Application/Analysis
9) What qis qthe qeffect qof qthe q∆32 qallele qof qCCR5 qon qHIV qbinding?
A) appears qon qthe qsurface qof qCD4 qT qcells, qbut qthe qHIV qvirion qis qunable qto qinfect qthe qhost qcell
B) does qnot qappear qon qthe qsurface qof qCD4 qT qcells
C) appears qon qthe qsurface qof qthe qCD4 qT qcells qand qinactivates qthe qvirion qupon qbinding
D) interferes qwith qbinding qof qthe qvirion qto qthe qCD4 qreceptor qprotein
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qInc.
,E) appears qon qthe qsurface qof qthe qCD4 qT qcells qand qcauses qthe qvirion qto qlyse qupon
qbinding qAnswer: q B
Section: q 1.3
Skill: q Application/Analysis
10) The q∆32 qallele qof qCCR5 qis qfound qat qthe qhighest qfrequency qin qwhich qof qthe
qfollowing qpopulations?
A) Africans
B) Japanese
C) North qAmericans
D) Europeans
E) South qAmericans
qAnswer: q D
q Section: q 1.3
Skill: q Knowledge/Comprehension
11) HIV-1 qis qbelieved qto qhave qbeen qtransmitted qto qhumans qfrom qwhich qof qthe
qfollowing qorganisms?
A) gorillas
B) sooty qmangabeys
C) African qgreen qmonkeys
D) chimpanzees
E) baboons
qAnswer: qD
qSection:
q 1.4
Skill: q Knowledge/Comprehension
12) HIV-1 qGroup qM qis qresponsible qfor q95% qof qhuman qinfections. qWhen qis qit qestimated qthat
qHIV-1 qGroup qM qwas qtransferred qto qhumans?
A) 1980
B) 1960
C) 1930
D) 1995
E) 1900
Answer: q C
qSection:
q 1.4
Skill: q Knowledge/Comprehension
13) Antibodies qand qkiller qT qcells qrecognize qHIV qor qHIV-infected qcells qby qbinding qto qshort
qpieces qof qviral qproteins qdisplayed qon qthe qvirus qor qthe qinfected qhost qcell. qThese qshort qpieces
qof qviral qproteins qare qcalled q .
A) coat qproteins
B) virosomes
C) proteosomes
D) epitopes
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qInc.
, E) episomes
qAnswer:
qD
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qInc.