Evolutionary Analysis 5th Edition by Herron Jon; Freeman Scott ISBN 9780321998378 Chapterix ix ix ix ix ix ix ix ix ix ix
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Chapter 1 ix i x i x A Case for Evolutionary Thinking: Understanding HIV
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1) In which of the following regions has AIDS killed the largest number of individuals?
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A) India
B) Sub-Saharan Africa ix
C) United States ix
D) China
E) UnitedKingdom ix
Answer: B
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iSection: 1.1
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Skill: Knowledge/Comprehension
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2) The HIV virus contains all of the following components except
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A) integrase
B) double-stranded RNA ix
C) single-stranded RNA ix
D) reverse transcriptase ix
E) protease
Answer: B
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Section:
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i1.1 x
Skill: Knowledge/Comprehension
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3) The acronym HIV stands for which of the following?
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A) human intercellular virus ix ix
B) human immune virus ix ix
C) human immunodeficiency virus ix ix
D) human immunity virus ix ix
E) humanimmunodeficiencyvector ix ix
Answer: C
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Section: 1.1 i x
Skill: Knowledge/Comprehension
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4) Which of the following enzymes is responsible for transcribing viral RNA into DNA?
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A) RNA polymerase ix
B) reverse transcriptase ix
C) DNA polymerase ix
D) reverse integrase ix
E) RNAduplicase ix
Answer: B
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Section: 1.1
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Skill: Knowledge/Comprehension
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Copyright © 2014 Pearson Education, Inc.
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,5) The proteins that enable the HIV virus to bind to cells are typically CD4 and CCR5. On what
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type of cells are these proteins typically observed?
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A) plasma cells ix
B) dendritic cells ix
C) effector helper T cells ix ix ix
D) memory helper T cells ix ix ix
E) both Cand D ix ix ix
Answer: E
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Section: 1.1
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Skill: Knowledge/Comprehension
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6) The AIDS phase of HIV infection begins when the concentration of CD4 T cells in the blood
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drops below what concentration?
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A) 2,000 cells per cubic millimeter ix ix ix ix
B) 1,000 cells per cubic millimeter ix ix ix ix
C) 500 cells per cubic millimeter
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D) 200 cells per cubic millimeter
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E) No CD4 T cells areobserved.
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Answer: D
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Section: 1.1 i x
Skill: Knowledge/Comprehension
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7) Which of the following drug categories are used to treat HIV infections?
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A) integrase inhibitors ix
B) protease inhibitors ix
C) reverse transcriptase inhibitors ix ix
D) DNAse inhibitors ix
E) fusioninhibitors ix
Answer: D
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Section: 1.2
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Skill: Knowledge/Comprehension
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8) Coreceptor inhibitors block HIV infection by preventing which of the following? ix ix ix ix ix ix ix ix ix ix
A) binding of the HIV virion onto the plasma membrane ix ix ix ix ix ix ix ix
B) binding of the HIV virion onto the CCR5 receptor ix ix ix ix ix ix ix ix
C) binding of the HIV virion onto the gp120 protein ix ix ix ix ix ix ix ix
D) degrading the coreceptor so the virion cannot attach ix ix ix ix ix ix ix
E) binding of the HIV virion onto the CD4 receptor ix ix ix ix ix ix ix ix
Answer: B
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Section: 1.2 i x
Skill: Application/Analysis
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9) What is the effect of the ∆32 allele of CCR5 on HIV binding?
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A) appears on the surface of CD4 T cells, but the HIV virion is unable to infect the host cell
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B) does not appear on the surface of CD4 T cells
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C) appears on the surface of the CD4 T cells and inactivates the virion upon binding
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D) interferes with binding of the virion to the CD4 receptor protein ix ix ix ix ix ix ix ix ix ix
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Copyright © 2014 Pearson Education, Inc. ix ix ix ix ix
,E) appears on the surface of the CD4 T cells and causes the virion to lyse upon binding
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Answer: B
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Section: 1.3 i x
Skill: Application/Analysis
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10) The ∆32 allele of CCR5 is found at the highest frequency in which of the following
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populations?
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A) Africans
B) Japanese
C) North Americans ix
D) Europeans
E) SouthAmericans ix
Answer: D
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i Section: 1.3
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Skill: Knowledge/Comprehension
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11) HIV-1 is believed to have been transmitted to humans from which of the following
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organisms?
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A) gorillas
B) sooty mangabeys ix
C) African green monkeys ix ix
D) chimpanzees
E) baboons
Answer: D
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Section:
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Skill: Knowledge/Comprehension
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12) HIV-1 Group M is responsible for 95% of human infections. When is it estimated that HIV-1
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Group M was transferred to humans?
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A) 1980
B) 1960
C) 1930
D) 1995
E) 1900
Answer: C i x
Section:
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Skill: Knowledge/Comprehension
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13) Antibodies and killer T cells recognize HIV or HIV-infected cells by binding to short pieces of
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viral proteins displayed on the virus or the infected host cell. These short pieces of viral proteins
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are called
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A) coat proteins ix
B) virosomes
C) proteosomes
D) epitopes
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, E) episomes
Answer: D
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