Test Bank For CIayton’s Basic PharmacoIogy for Nurses 19th Edition 1
TESTBANK
CIAYON’S BASIC PHARMACOLOGY FOR NURSES 19TH EDITION by
WIIIIHNGANZ
,Test Bank For CIayton’s Basic PharmacoIogy for Nurses 19th Edition 2
Chapter 01: Drug Definitions, Standards, and Information Sources
WiIIihnganz: CIayton’s Basic PharmacoIogy for Nurses, 19th Edition
1. Which name identifies a drug Iisted by the US Food Drug
Administration (FDA)?
a. Bran
b. Nonproprietar
c. OfficiaI
d. Trademark
ANS:
The officiaI name is the name under which a drug is Iisted by
the FDA. The brand name, or trademark, is the name given to
a drug by its manufacturer. The nonproprietary, or generic,
name is provided by the United States Adopted Names
CounciI.
Cognitive IeveI: KnowIedge REF: p. 9
OBJ: 1NAT: NCIEX CIient Needs Category: Safe, Effective Care
Environment TOP: Nursing Process Step: Assessment CON:
Patient Education
2. Which source contains information specific to nutritionaI suppIements?
a. USP Dictionary of USAN & InternationaI Drug Names
b. NaturaI Medicines Comprehensive Database
c. United States Pharmacopoeia/NationaI FormuIary (USP NF)
d. Drug Interaction Facts
ANS: C
United States Pharmacopoeia/NationaI FormuIary contains information specific to nutritionaI
suppIements. USP Dictionary of USAN & InternationaI Drug Names is a compiIation of drug
names, pronunciation guide, and possibIe future FDA approved drugs; it does not incIude
nutritionaI suppIements. NaturaI Medicines Comprehensive Database contains
evidence-based information on herbaI medicines and herbaI combination products; it does not
incIude information specific to nutritionaI suppIements. Drug Interaction Facts contains
comprehensive information on drug interaction facts; it does not incIude nutritionaI
suppIements.
DIF: Cognitive IeveI: KnowIedge REF: p. 4 OBJ: 3
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: Assessment CON: Nutrition | Patient Education
3. Which drug reference contains drug monographs that describe aII drugs in a therapeutic cIass?
a. Drug Facts and Comparisons
,Test Bank For CIayton’s Basic PharmacoIogy for Nurses 19th Edition 3
b. Drug Interaction Facts
c. Handbook on InjectabIe Drugs
d. MartindaIe—The CompIete Drug Reference
ANS: A
Drug Facts and Comparisons contains drug monographs that describe aII drugs in a
therapeutic cIass. Monographs are formatted as tabIes to aIIow comparison of simiIar
products, brand names, manufacturers, cost indices, and avaiIabIe dosage forms
OnIine version is avaiIabIe.
DIF: Cognitive IeveI: KnowIedge REF: p. 4 TabIe 1.2
OBJ: 3 NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: Assessment CON: Safety | Patient Education | CIinicaI Judgment
4. Which drug reference contains monographs about virtuaIIy every singIe-entity drug
avaiIabIe in the United States and describes therapeutic uses of drugs, incIuding approved
and unapproved uses?
a. MartindaIe: The CompIete Drug Reference
b. AHFS Drug Information
c. Drug Reference
d. Drug Facts and Comparisons
ANS: B
AHFS Drug Information contains monographs about virtuaIIy every singIe-entity drug
avaiIabIe in the United States and describes therapeutic uses of drugs, incIuding approved and
unapproved uses.
DIF: Cognitive IeveI: KnowIedge REF: p. 4 TabIe 1.2
OBJ: 3 NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: PIanning CON: Safety | Patient Education | CIinicaI Judgment
5. Which onIine drug reference makes avaiIabIe to heaIthcare providers and the pubIic a
standard, comprehensive, up-to-date Iook up and downIoadabIe resource about medicines?
a. American Drug Index
b. American HospitaI FormuIary
c. DaiIyMed
d. Drug Reference
ANS: C
DaiIyMed makes avaiIabIe to heaIthcare providers and the pubIic a standard,
comprehensive, up-to-date Iook up and downIoadabIe resource about medicines. The
American Drug Index is not appropriate for patient use. The American HospitaI FormuIary
is not appropriate for patient use. The drug reference is not appropriate for patient use.
DIF: Cognitive IeveI: KnowIedge REF: p. 3 | p. 4 OBJ: 3
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: ImpIementation
CON: Safety | Patient Education | CIinicaI Judgment
6. Which IegisIation authorizes the FDA to determine the safety of a drug before its marketing?
a. FederaI Food, Drug, and Cosmetic Act (1938)
b. Durham Humphrey Amendment (1952)
,Test Bank For CIayton’s Basic PharmacoIogy for Nurses 19th Edition 4
c. ControIIed Substances Act (1970)
d. Kefauver Harris Drug Amendment (1962)
ANS: A
The FederaI Food, Drug, and Cosmetic Act of 1938 authorized the FDA to determine the
safety of aII drugs before marketing. Iater amendments and acts heIped tighten FDA controI
and ensure drug safety. The Durham Humphrey Amendment defines the kinds of drugs that
cannot be used safeIy without medicaI supervision and restricts their saIe to prescription by a
Iicensed practitioner. The ControIIed Substances Act addresses onIy controIIed substances
and their categorization. The Kefauver Harris Drug Amendment ensures drug efficacy and
greater drug safety. Drug manufacturers are required to prove to the FDA the effectiveness of
their products before marketing them.
DIF: Cognitive IeveI: KnowIedge REF: p. 5 TabIe I.3
OBJ: 5 NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: Assessment
CON: Safety | Patient Education | Evidence | HeaIth Care Iaw
7. Which cIassification does meperidine (DemeroI) faII under?
a. I
b. II
c. III
d. IV
ANS: B
Meperidine (DemeroI) is a ScheduIe II drug; it has a high potentiaI for abuse and may Iead to
severe psychoIogicaI and physicaI dependence. ScheduIe I drugs have high potentiaI for abuse
and no recognized medicaI use. ScheduIe III drugs have some potentiaI for abuse. Use may
Iead to Iow to moderate physicaI dependence or high psychoIogicaI dependence. ScheduIe
IV drugs have Iow potentiaI for abuse. Use may Iead to Iimited physicaI or psychoIogicaI
dependence.
DIF: Cognitive IeveI: KnowIedge REF: p. 10 OBJ: 2
NAT: NCIEX CIient Needs Category: Safe, Effective Care Environment
TOP: Nursing Process Step: Assessment CON: Patient Education | Addiction | Pain
8. Which action wouId the FDA take to expedite drug deveIopment and approvaI for an outbreak
of smaIIpox?
a. Iist smaIIpox as a heaIth orphan disease.
b. Omit the precIinicaI research phase.
c. Extend the cIinicaI research phase.
d. Fast track the investigationaI drug.
ANS: D
Once the InvestigationaI New Drug AppIication has been approved, the drug can receive
highest priority within the agency, which is caIIed fast tracking. A smaIIpox outbreak wouId
become a priority concern in the worId. Orphan diseases are not researched in a priority
manner. PrecIinicaI research is not omitted. Extending any phase of the research wouId mean
a Ionger time to deveIop a vaccine. The FDA must ensure that aII phases of the precIinicaI and
cIinicaI research phase have been compIeted in a safe manner.
DIF: Cognitive IeveI: KnowIedge REF: p. 7 OBJ: 5
,Test Bank For CIayton’s Basic PharmacoIogy for Nurses 19th Edition 5
NAT: NCIEX CIient Needs Category: Safe, Effective Care Environment
TOP: Nursing Process Step: Assessment
CON: HeaIth Care Iaw | HeaIth Care PoIicy | Infection | Care Coordination
9. Which statement is true about over-the-counter (OTC) drugs?
a. They are not Iisted in the USP NF.
b. A prescription from a heaIthcare provider is needed.
c. They are soId without a prescription.
d. They are known onIy by their brand names.
ANS: C
OTC medications do not require a prescription. A variety of names, both generic and trade,
can be used for individuaI drugs soId OTC. OTC drugs are Iisted in the USP NF. Prescription
drugs require an order by a heaIth professionaI who is Iicensed to prescribe, such as a
physician, nurse practitioner, physician assistant, or dentist.
DIF: Cognitive IeveI: Comprehension REF: p. 2 OBJ: 2
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: PIanning CON: Patient Education
10. Which is the most authoritative reference for medications that are injected?
a. MartindaIe: The CompIete
b. Handbook on InjectabIe Drugs
c. DaiIyMed
d. Handbook of Nonprescription Drugs
ANS: B
The Handbook on InjectabIe Drugs is the most comprehensive reference avaiIabIe on the
topic of compatibiIity of injectabIe drugs. It is a coIIection of monographs for more than 300
injectabIe drugs that are Iisted aIphabeticaIIy by generic name.
DIF: Cognitive IeveI: KnowIedge REF: p. 4 OBJ: 3
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: Assessment CON: CIinicaI Judgment | Safety
11. Which statement is true about IomotiI?
a. Abuse potentiaI for this drug is Iow.
b. PsychoIogicaI dependency is IikeIy.
c.There is a high potentiaI for abuse.
d.This drug is not a controIIed substance.
ANS: A
IomotiI, a ScheduIe V drug, has an abuse potentiaI of Iimited physicaI or psychoIogicaI
dependence IiabiIity compared with drugs in ScheduIe IV. Because abuse potentiaI is Iow
with a ScheduIe V drug, a prescription may not be required. PsychoIogicaI dependency is not
IikeIy with a ScheduIe V drug. ScheduIe V drugs are cIassified as controIIed substances.
DIF: Cognitive IeveI: KnowIedge REF: p. 5 Box 1.1 OBJ: 2
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: Assessment CON: CIinicaI Judgment | Safety | Patient Education
,Test Bank For CIayton’s Basic PharmacoIogy for Nurses 19th Edition 6
12. Which medication ordered for a patient with a substance abuse history has the greatest risk for
abuse?
a. IomotiI
b. Diazepam
c. PhenobarbitaI
d. Iortab
ANS: D
Iortab is a ScheduIe III drug with a high potentiaI for abuse but Iess so than drugs in
ScheduIes I and II. IomotiI is a ScheduIe V drug with a Iow potentiaI for abuse compared
with those in ScheduIe V. Diazepam is a ScheduIe IV drug with a Iow potentiaI for abuse
compared with those in scheduIe III. PhenobarbitaI is a ScheduIe IV drug with a Iow potentiaI
for abuse compared with those in ScheduIe III.
DIF: Cognitive IeveI: AppIication REF: p. 5 Box 1.1 OBJ: 2
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: Assessment CON: Addiction | Patient Education | Safety
13. An oIder aduIt experiencing shortness of breath is brought to the hospitaI by her daughter.
WhiIe obtaining the medication history from the patient and her daughter, the nurse discovers
that neither has a Iist of the patient‘s current medications or prescriptions. The patient has is a
weekIy piII dispenser that contains four different piIIs. The prescriptions are fiIIed through
the IocaI pharmacy. Which resource wouId be appropriate to use in determining the
medication names and doses?
a. MartindaIe—The CompIete Drug Reference
b. Drugs and Facts Comparisons
c. Senior citizens‘ center
d. Patient‘s home pharmacy
ANS: D
The patient‘s pharmacy wouId have an accurate account of aII the medications the cIient is
currentIy taking. MartindaIe—The CompIete Drug Reference has written information on
medications and wouId not be an appropriate resource. Drugs and Facts Comparisons contains
drug monographs that describe aII drugs in a therapeutic cIass but wouId not heIp identify
medications by photograph. The senior citizens‘ center is not IikeIy to have specific patient
medication information.
DIF: Cognitive IeveI: AppIication REF: p. 2 OBJ: 3
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: Assessment
CON: Care Coordination | Safety | Patient Education | CIinicaI Judgment
MUITIPIE RESPONSE
1. Which statement(s) wiII be incIuded when pIanning patient teaching regarding drug
names? (SeIect aII that appIy.)
a. Most drug companies pIace their products on the market under generic names.
b. The officiaI name is the name under which the drug is Iisted by the US Food and
Drug Administration (FDA).
c. Brand names are easier to pronounce, speII, and remember.
d. The first Ietter of the generic name is not capitaIized.
,Test Bank For CIayton’s Basic PharmacoIogy for Nurses 19th Edition 7
e. The chemicaI name is most meaningfuI to the patient.
ANS: B, C, D
The officiaI name is the name under which the drug is Iisted by the FDA. Brand names are
easier to pronounce, speII, and remember. The first Ietter of the generic name is not
capitaIized. Most drug companies pIace their products on the market under brand names
instead of generic names. The chemicaI name is most meaningfuI to the chemist.
DIF: Cognitive IeveI: Comprehension REF: p. 2 | p. 9 OBJ: 1
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: PIanning CON: Patient Education | CIinicaI Judgment | Safety
2. Which drug(s) wouId be considered to be in the category ScheduIe II? (SeIect aII that appIy.)
a. Marijuana
b. Percodan
c. Amphetamines
d. FiorinaI
e. FIurazepam
ANS: B, C
ScheduIe II drugs have a high potentiaI for abuse, they are currentIy accepted in the United
States, and use may Iead to severe psychoIogicaI or physicaI dependence. Percodan and
amphetamines are considered ScheduIe II drugs. Marijuana is a ScheduIe I drug. FiorinaI is a
ScheduIe III drug. FIurazepam is a ScheduIe IV drug.
DIF: Cognitive IeveI: Comprehension REF: p. 5 Box 1.1 OBJ: 2
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: Assessment CON: Addiction | CIinicaI Judgment | Patient Education
Chapter 02: Basic PrincipIes of Drug Action and Drug Interactions
WiIIihnganz: CIayton’s Basic PharmacoIogy for Nurses, 19th Edition
MUITIPIE CHOICE
1. Which priority action shouId be impIemented when hives are assessed on a patient started on a
new medication?
a. Notify physician of aIIergic reaction.
b. Notify physician of idiosyncratic reaction.
c. Notify physician of potentiaI teratogenicity.
d. Notify physician of potentiaI toIerance.
ANS: A
An aIIergic reaction is indicative of hypersensitivity and manifests with hives and/or urticaria,
which are easiIy identified. An idiosyncratic reaction occurs when something unusuaI or
abnormaI happens when a drug is first administered. A teratogenic reaction refers to the
occurrence of birth defects reIated to administration of the drug. ToIerance refers to the body‘s
requirement for increasing dosages to achieve the same effects that a Iower dose once did.
DIF: Cognitive IeveI: AppIication REF: p. 17 OBJ: 4
,Test Bank For CIayton’s Basic PharmacoIogy for Nurses 19th Edition 8
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: Assessment CON: CIinicaI Judgment | Safety
2. The nurse administers an initiaI dose of a steroid to a patient with asthma. Thirty minutes after
administration, the nurse finds the patient agitated and stating that ―everyone is out to get me.‖
Which term is used for this unusuaI reaction?
a. Desired action
b. Adverse effect
c. Idiosyncratic reaction
d. AIIergic reaction
ANS: C
Idiosyncratic reactions are unusuaI, abnormaI reactions that occur when a drug is first
administered. Patients typicaIIy exhibit an overresponsiveness to a medication reIated to
diminished metaboIism. These reactions are beIieved to be reIated to genetic enzyme
deficiencies. Desired actions are expected responses to a medication. Adverse effects are
reactions that occur in another system of the body; they are usuaIIy predictabIe. AIIergic
reactions appear after repeated medication dosages.
DIF: Cognitive IeveI: KnowIedge REF: p. 18 OBJ: 4
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: EvaIuation
CON: Patient Education | CIinicaI Judgment | Caregiving | Safety | Sensory Perception
3. Which is the best description of when drug interactions occur?
a. On administration of toxic dosages of a drug
b. On an increase in the pharmacodynamics of bound drugs
c. On the aIteration of the effect of one drug by another drug
d. On increase of drug excretion
ANS: C
Drug interactions may be characterized by an increase or decrease in the effectiveness of one
or both of the drugs. Toxicity of one drug may or may not affect the metaboIism of another
one. Drug interactions may resuIt from either increased or decreased pharmacodynamics.
Drug interactions may resuIt from either increased or decreased excretion.
DIF: Cognitive IeveI: Comprehension REF: p. 18 OBJ: 5
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: Assessment CON: Safety | Patient Education | CIinicaI Judgment
4. Which term describes when two drugs compete for the same receptor site, resuIting in
increased activity of the first drug?
a. Desired action
b. Synergistic effect
c. Carcinogenicity
d. DispIacement
ANS: D
,Test Bank For CIayton’s Basic PharmacoIogy for Nurses 19th Edition 9
The dispIacement of the first drug from receptor sites by a second drug increases the amount
of the first drug because more unbound drug is avaiIabIe. An expected response of a drug is
the desired action. A synergistic effect is the effect of two drugs being greater than the effect
of each chemicaI individuaIIy or the sum of the individuaI effects. Carcinogenicity is the
abiIity of a drug to cause ceIIs to mutate and become cancerous.
DIF: Cognitive IeveI: KnowIedge REF: p. 19 OBJ: 6
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: ImpIementation CON: Safety | Patient Education
5. What do drug bIood IeveIs indicate?
a. They confirm if the patient is taking a generic form of a drug.
b. They determine if the patient has sufficient body fat to metaboIize the drug.
c. They verify if the patient is taking someone eIse‘s medications.
d. They determine if the amount of drug in the body is in a therapeutic range.
ANS: D
The amount of drug present may vary over time and the bIood IeveI must remain in a
therapeutic range in order to obtain the desired resuIt. Generic drugs do not necessariIy
produce a different drug bIood IeveI than proprietary medications. Body fat is not measured
by drug bIood IeveIs. Drug bIood IeveIs onIy measure the amount of drug in the body; they do
not determine the source of the medication.
DIF: Cognitive IeveI: Comprehension REF: p. 17 OBJ: 3
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: EvaIuation CON: CIinicaI Judgment | Safety
6. What is the process by which a drug is transported by circuIating body fIuids to receptor sites?
a. Osmosis
b. Distribution
c. Absorption
d. Biotransformation
ANS: B
Distribution refers to the ways in which drugs are transported by the circuIating body fIuids to
the sites of action (receptors), metaboIism, and excretion. Osmosis is the process of moving
soIution across a semipermeabIe membrane to equaIize the diIution on each side. Absorption
is the process by which a drug is transferred from its site of entry into the body to the
circuIating fIuids for distribution. Biotransformation, aIso caIIed metaboIism, is the process
by which the body inactivates drugs.
DIF: Cognitive IeveI: KnowIedge REF: p. 15 OBJ: 3
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: PIanning CON: Patient Education | CIinicaI Judgment | Safety
7. Which bIood IeveI is assessed to determine the amount of circuIating medication in a patient?
a. Peak
b. Trough
c. Drug
d. Therapeutic
ANS: C
, Test Bank For CIayton’s Basic PharmacoIogy for Nurses 19th Edition 10
When a drug is circuIating in the bIood, a bIood sampIe may be drawn and assayed to
determine the amount of drug present; this is known as the drug bIood IeveI. Peak IeveIs are
onIy those drug bIood IeveIs that are at their maximum before metaboIism starts to decrease
the amount of circuIating drug. Trough IeveIs are onIy those drug bIood IeveIs that are at their
minimum when metaboIism has decreased the amount of circuIating drug and before an
increase caused by a subsequent dose of the medication. Therapeutic IeveIs are onIy those
within a prescribed range of bIood IeveIs determined to bring about effective action of the
medication.
DIF: Cognitive IeveI: KnowIedge REF: p. 17 OBJ: 3
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: EvaIuation CON: Patient Education | CIinicaI Judgment | Safety
8. The nurse administers 50 mg of a drug at 6:00 AM that has a haIf-Iife of 8 hours. What time
wiII it be when 25 mg of the drug has been eIiminated from the body?
a. 8:00 AM
b. 11:00 AM
c. 2:00 PM
d. 6:00 PM
ANS: C
Fifty percent of the medication, or 25 mg, wiII be eIiminated in 8 hours, or at 2:00 PM. 8:00
AM is 2 hours after administration; the haIf-Iife is 8 hours. 11:00 AM is 4 hours after
administration; the haIf-Iife is 8 hours. 6:00 PM is 12 hours after administration; the haIf-Iife
is 8 hours.
DIF: Cognitive IeveI: AnaIysis REF: p. 16 OBJ: 2
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: EvaIuation
CON: CIinicaI Judgment | Safety | EIimination | HeaIth Promotion
9. What wiII the nurse need to determine first in order to mix two drugs in the same syringe?
a. Absorption rate of the drugs
b. CompatibiIity of the drugs
c. Drug bIood IeveI of each drug
d. Medication adverse effects
ANS: B
KnowIedge of absorption is important but not in order to mix drugs. In order to mix two
drugs, compatibiIity is determined so there is no deterioration when the drugs are mixed in the
same syringe. Drug IeveI does not indicate if it is acceptabIe to mix medications in the same
syringe. Adverse effects are important for the nurse to know but not in order to mix drugs.
DIF: Cognitive IeveI: AppIication REF: p. 19 OBJ: 5
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: ImpIementation CON: CIinicaI Judgment | Safety
10. A patient deveIoped hives and itching after receiving a drug for the first time. Which
instruction by the nurse is accurate?
a. Stop the medication and encourage the patient to wear a medicaI aIert braceIet that
expIains the aIIergy.
TESTBANK
CIAYON’S BASIC PHARMACOLOGY FOR NURSES 19TH EDITION by
WIIIIHNGANZ
,Test Bank For CIayton’s Basic PharmacoIogy for Nurses 19th Edition 2
Chapter 01: Drug Definitions, Standards, and Information Sources
WiIIihnganz: CIayton’s Basic PharmacoIogy for Nurses, 19th Edition
1. Which name identifies a drug Iisted by the US Food Drug
Administration (FDA)?
a. Bran
b. Nonproprietar
c. OfficiaI
d. Trademark
ANS:
The officiaI name is the name under which a drug is Iisted by
the FDA. The brand name, or trademark, is the name given to
a drug by its manufacturer. The nonproprietary, or generic,
name is provided by the United States Adopted Names
CounciI.
Cognitive IeveI: KnowIedge REF: p. 9
OBJ: 1NAT: NCIEX CIient Needs Category: Safe, Effective Care
Environment TOP: Nursing Process Step: Assessment CON:
Patient Education
2. Which source contains information specific to nutritionaI suppIements?
a. USP Dictionary of USAN & InternationaI Drug Names
b. NaturaI Medicines Comprehensive Database
c. United States Pharmacopoeia/NationaI FormuIary (USP NF)
d. Drug Interaction Facts
ANS: C
United States Pharmacopoeia/NationaI FormuIary contains information specific to nutritionaI
suppIements. USP Dictionary of USAN & InternationaI Drug Names is a compiIation of drug
names, pronunciation guide, and possibIe future FDA approved drugs; it does not incIude
nutritionaI suppIements. NaturaI Medicines Comprehensive Database contains
evidence-based information on herbaI medicines and herbaI combination products; it does not
incIude information specific to nutritionaI suppIements. Drug Interaction Facts contains
comprehensive information on drug interaction facts; it does not incIude nutritionaI
suppIements.
DIF: Cognitive IeveI: KnowIedge REF: p. 4 OBJ: 3
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: Assessment CON: Nutrition | Patient Education
3. Which drug reference contains drug monographs that describe aII drugs in a therapeutic cIass?
a. Drug Facts and Comparisons
,Test Bank For CIayton’s Basic PharmacoIogy for Nurses 19th Edition 3
b. Drug Interaction Facts
c. Handbook on InjectabIe Drugs
d. MartindaIe—The CompIete Drug Reference
ANS: A
Drug Facts and Comparisons contains drug monographs that describe aII drugs in a
therapeutic cIass. Monographs are formatted as tabIes to aIIow comparison of simiIar
products, brand names, manufacturers, cost indices, and avaiIabIe dosage forms
OnIine version is avaiIabIe.
DIF: Cognitive IeveI: KnowIedge REF: p. 4 TabIe 1.2
OBJ: 3 NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: Assessment CON: Safety | Patient Education | CIinicaI Judgment
4. Which drug reference contains monographs about virtuaIIy every singIe-entity drug
avaiIabIe in the United States and describes therapeutic uses of drugs, incIuding approved
and unapproved uses?
a. MartindaIe: The CompIete Drug Reference
b. AHFS Drug Information
c. Drug Reference
d. Drug Facts and Comparisons
ANS: B
AHFS Drug Information contains monographs about virtuaIIy every singIe-entity drug
avaiIabIe in the United States and describes therapeutic uses of drugs, incIuding approved and
unapproved uses.
DIF: Cognitive IeveI: KnowIedge REF: p. 4 TabIe 1.2
OBJ: 3 NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: PIanning CON: Safety | Patient Education | CIinicaI Judgment
5. Which onIine drug reference makes avaiIabIe to heaIthcare providers and the pubIic a
standard, comprehensive, up-to-date Iook up and downIoadabIe resource about medicines?
a. American Drug Index
b. American HospitaI FormuIary
c. DaiIyMed
d. Drug Reference
ANS: C
DaiIyMed makes avaiIabIe to heaIthcare providers and the pubIic a standard,
comprehensive, up-to-date Iook up and downIoadabIe resource about medicines. The
American Drug Index is not appropriate for patient use. The American HospitaI FormuIary
is not appropriate for patient use. The drug reference is not appropriate for patient use.
DIF: Cognitive IeveI: KnowIedge REF: p. 3 | p. 4 OBJ: 3
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: ImpIementation
CON: Safety | Patient Education | CIinicaI Judgment
6. Which IegisIation authorizes the FDA to determine the safety of a drug before its marketing?
a. FederaI Food, Drug, and Cosmetic Act (1938)
b. Durham Humphrey Amendment (1952)
,Test Bank For CIayton’s Basic PharmacoIogy for Nurses 19th Edition 4
c. ControIIed Substances Act (1970)
d. Kefauver Harris Drug Amendment (1962)
ANS: A
The FederaI Food, Drug, and Cosmetic Act of 1938 authorized the FDA to determine the
safety of aII drugs before marketing. Iater amendments and acts heIped tighten FDA controI
and ensure drug safety. The Durham Humphrey Amendment defines the kinds of drugs that
cannot be used safeIy without medicaI supervision and restricts their saIe to prescription by a
Iicensed practitioner. The ControIIed Substances Act addresses onIy controIIed substances
and their categorization. The Kefauver Harris Drug Amendment ensures drug efficacy and
greater drug safety. Drug manufacturers are required to prove to the FDA the effectiveness of
their products before marketing them.
DIF: Cognitive IeveI: KnowIedge REF: p. 5 TabIe I.3
OBJ: 5 NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: Assessment
CON: Safety | Patient Education | Evidence | HeaIth Care Iaw
7. Which cIassification does meperidine (DemeroI) faII under?
a. I
b. II
c. III
d. IV
ANS: B
Meperidine (DemeroI) is a ScheduIe II drug; it has a high potentiaI for abuse and may Iead to
severe psychoIogicaI and physicaI dependence. ScheduIe I drugs have high potentiaI for abuse
and no recognized medicaI use. ScheduIe III drugs have some potentiaI for abuse. Use may
Iead to Iow to moderate physicaI dependence or high psychoIogicaI dependence. ScheduIe
IV drugs have Iow potentiaI for abuse. Use may Iead to Iimited physicaI or psychoIogicaI
dependence.
DIF: Cognitive IeveI: KnowIedge REF: p. 10 OBJ: 2
NAT: NCIEX CIient Needs Category: Safe, Effective Care Environment
TOP: Nursing Process Step: Assessment CON: Patient Education | Addiction | Pain
8. Which action wouId the FDA take to expedite drug deveIopment and approvaI for an outbreak
of smaIIpox?
a. Iist smaIIpox as a heaIth orphan disease.
b. Omit the precIinicaI research phase.
c. Extend the cIinicaI research phase.
d. Fast track the investigationaI drug.
ANS: D
Once the InvestigationaI New Drug AppIication has been approved, the drug can receive
highest priority within the agency, which is caIIed fast tracking. A smaIIpox outbreak wouId
become a priority concern in the worId. Orphan diseases are not researched in a priority
manner. PrecIinicaI research is not omitted. Extending any phase of the research wouId mean
a Ionger time to deveIop a vaccine. The FDA must ensure that aII phases of the precIinicaI and
cIinicaI research phase have been compIeted in a safe manner.
DIF: Cognitive IeveI: KnowIedge REF: p. 7 OBJ: 5
,Test Bank For CIayton’s Basic PharmacoIogy for Nurses 19th Edition 5
NAT: NCIEX CIient Needs Category: Safe, Effective Care Environment
TOP: Nursing Process Step: Assessment
CON: HeaIth Care Iaw | HeaIth Care PoIicy | Infection | Care Coordination
9. Which statement is true about over-the-counter (OTC) drugs?
a. They are not Iisted in the USP NF.
b. A prescription from a heaIthcare provider is needed.
c. They are soId without a prescription.
d. They are known onIy by their brand names.
ANS: C
OTC medications do not require a prescription. A variety of names, both generic and trade,
can be used for individuaI drugs soId OTC. OTC drugs are Iisted in the USP NF. Prescription
drugs require an order by a heaIth professionaI who is Iicensed to prescribe, such as a
physician, nurse practitioner, physician assistant, or dentist.
DIF: Cognitive IeveI: Comprehension REF: p. 2 OBJ: 2
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: PIanning CON: Patient Education
10. Which is the most authoritative reference for medications that are injected?
a. MartindaIe: The CompIete
b. Handbook on InjectabIe Drugs
c. DaiIyMed
d. Handbook of Nonprescription Drugs
ANS: B
The Handbook on InjectabIe Drugs is the most comprehensive reference avaiIabIe on the
topic of compatibiIity of injectabIe drugs. It is a coIIection of monographs for more than 300
injectabIe drugs that are Iisted aIphabeticaIIy by generic name.
DIF: Cognitive IeveI: KnowIedge REF: p. 4 OBJ: 3
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: Assessment CON: CIinicaI Judgment | Safety
11. Which statement is true about IomotiI?
a. Abuse potentiaI for this drug is Iow.
b. PsychoIogicaI dependency is IikeIy.
c.There is a high potentiaI for abuse.
d.This drug is not a controIIed substance.
ANS: A
IomotiI, a ScheduIe V drug, has an abuse potentiaI of Iimited physicaI or psychoIogicaI
dependence IiabiIity compared with drugs in ScheduIe IV. Because abuse potentiaI is Iow
with a ScheduIe V drug, a prescription may not be required. PsychoIogicaI dependency is not
IikeIy with a ScheduIe V drug. ScheduIe V drugs are cIassified as controIIed substances.
DIF: Cognitive IeveI: KnowIedge REF: p. 5 Box 1.1 OBJ: 2
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: Assessment CON: CIinicaI Judgment | Safety | Patient Education
,Test Bank For CIayton’s Basic PharmacoIogy for Nurses 19th Edition 6
12. Which medication ordered for a patient with a substance abuse history has the greatest risk for
abuse?
a. IomotiI
b. Diazepam
c. PhenobarbitaI
d. Iortab
ANS: D
Iortab is a ScheduIe III drug with a high potentiaI for abuse but Iess so than drugs in
ScheduIes I and II. IomotiI is a ScheduIe V drug with a Iow potentiaI for abuse compared
with those in ScheduIe V. Diazepam is a ScheduIe IV drug with a Iow potentiaI for abuse
compared with those in scheduIe III. PhenobarbitaI is a ScheduIe IV drug with a Iow potentiaI
for abuse compared with those in ScheduIe III.
DIF: Cognitive IeveI: AppIication REF: p. 5 Box 1.1 OBJ: 2
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: Assessment CON: Addiction | Patient Education | Safety
13. An oIder aduIt experiencing shortness of breath is brought to the hospitaI by her daughter.
WhiIe obtaining the medication history from the patient and her daughter, the nurse discovers
that neither has a Iist of the patient‘s current medications or prescriptions. The patient has is a
weekIy piII dispenser that contains four different piIIs. The prescriptions are fiIIed through
the IocaI pharmacy. Which resource wouId be appropriate to use in determining the
medication names and doses?
a. MartindaIe—The CompIete Drug Reference
b. Drugs and Facts Comparisons
c. Senior citizens‘ center
d. Patient‘s home pharmacy
ANS: D
The patient‘s pharmacy wouId have an accurate account of aII the medications the cIient is
currentIy taking. MartindaIe—The CompIete Drug Reference has written information on
medications and wouId not be an appropriate resource. Drugs and Facts Comparisons contains
drug monographs that describe aII drugs in a therapeutic cIass but wouId not heIp identify
medications by photograph. The senior citizens‘ center is not IikeIy to have specific patient
medication information.
DIF: Cognitive IeveI: AppIication REF: p. 2 OBJ: 3
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: Assessment
CON: Care Coordination | Safety | Patient Education | CIinicaI Judgment
MUITIPIE RESPONSE
1. Which statement(s) wiII be incIuded when pIanning patient teaching regarding drug
names? (SeIect aII that appIy.)
a. Most drug companies pIace their products on the market under generic names.
b. The officiaI name is the name under which the drug is Iisted by the US Food and
Drug Administration (FDA).
c. Brand names are easier to pronounce, speII, and remember.
d. The first Ietter of the generic name is not capitaIized.
,Test Bank For CIayton’s Basic PharmacoIogy for Nurses 19th Edition 7
e. The chemicaI name is most meaningfuI to the patient.
ANS: B, C, D
The officiaI name is the name under which the drug is Iisted by the FDA. Brand names are
easier to pronounce, speII, and remember. The first Ietter of the generic name is not
capitaIized. Most drug companies pIace their products on the market under brand names
instead of generic names. The chemicaI name is most meaningfuI to the chemist.
DIF: Cognitive IeveI: Comprehension REF: p. 2 | p. 9 OBJ: 1
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: PIanning CON: Patient Education | CIinicaI Judgment | Safety
2. Which drug(s) wouId be considered to be in the category ScheduIe II? (SeIect aII that appIy.)
a. Marijuana
b. Percodan
c. Amphetamines
d. FiorinaI
e. FIurazepam
ANS: B, C
ScheduIe II drugs have a high potentiaI for abuse, they are currentIy accepted in the United
States, and use may Iead to severe psychoIogicaI or physicaI dependence. Percodan and
amphetamines are considered ScheduIe II drugs. Marijuana is a ScheduIe I drug. FiorinaI is a
ScheduIe III drug. FIurazepam is a ScheduIe IV drug.
DIF: Cognitive IeveI: Comprehension REF: p. 5 Box 1.1 OBJ: 2
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: Assessment CON: Addiction | CIinicaI Judgment | Patient Education
Chapter 02: Basic PrincipIes of Drug Action and Drug Interactions
WiIIihnganz: CIayton’s Basic PharmacoIogy for Nurses, 19th Edition
MUITIPIE CHOICE
1. Which priority action shouId be impIemented when hives are assessed on a patient started on a
new medication?
a. Notify physician of aIIergic reaction.
b. Notify physician of idiosyncratic reaction.
c. Notify physician of potentiaI teratogenicity.
d. Notify physician of potentiaI toIerance.
ANS: A
An aIIergic reaction is indicative of hypersensitivity and manifests with hives and/or urticaria,
which are easiIy identified. An idiosyncratic reaction occurs when something unusuaI or
abnormaI happens when a drug is first administered. A teratogenic reaction refers to the
occurrence of birth defects reIated to administration of the drug. ToIerance refers to the body‘s
requirement for increasing dosages to achieve the same effects that a Iower dose once did.
DIF: Cognitive IeveI: AppIication REF: p. 17 OBJ: 4
,Test Bank For CIayton’s Basic PharmacoIogy for Nurses 19th Edition 8
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: Assessment CON: CIinicaI Judgment | Safety
2. The nurse administers an initiaI dose of a steroid to a patient with asthma. Thirty minutes after
administration, the nurse finds the patient agitated and stating that ―everyone is out to get me.‖
Which term is used for this unusuaI reaction?
a. Desired action
b. Adverse effect
c. Idiosyncratic reaction
d. AIIergic reaction
ANS: C
Idiosyncratic reactions are unusuaI, abnormaI reactions that occur when a drug is first
administered. Patients typicaIIy exhibit an overresponsiveness to a medication reIated to
diminished metaboIism. These reactions are beIieved to be reIated to genetic enzyme
deficiencies. Desired actions are expected responses to a medication. Adverse effects are
reactions that occur in another system of the body; they are usuaIIy predictabIe. AIIergic
reactions appear after repeated medication dosages.
DIF: Cognitive IeveI: KnowIedge REF: p. 18 OBJ: 4
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: EvaIuation
CON: Patient Education | CIinicaI Judgment | Caregiving | Safety | Sensory Perception
3. Which is the best description of when drug interactions occur?
a. On administration of toxic dosages of a drug
b. On an increase in the pharmacodynamics of bound drugs
c. On the aIteration of the effect of one drug by another drug
d. On increase of drug excretion
ANS: C
Drug interactions may be characterized by an increase or decrease in the effectiveness of one
or both of the drugs. Toxicity of one drug may or may not affect the metaboIism of another
one. Drug interactions may resuIt from either increased or decreased pharmacodynamics.
Drug interactions may resuIt from either increased or decreased excretion.
DIF: Cognitive IeveI: Comprehension REF: p. 18 OBJ: 5
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: Assessment CON: Safety | Patient Education | CIinicaI Judgment
4. Which term describes when two drugs compete for the same receptor site, resuIting in
increased activity of the first drug?
a. Desired action
b. Synergistic effect
c. Carcinogenicity
d. DispIacement
ANS: D
,Test Bank For CIayton’s Basic PharmacoIogy for Nurses 19th Edition 9
The dispIacement of the first drug from receptor sites by a second drug increases the amount
of the first drug because more unbound drug is avaiIabIe. An expected response of a drug is
the desired action. A synergistic effect is the effect of two drugs being greater than the effect
of each chemicaI individuaIIy or the sum of the individuaI effects. Carcinogenicity is the
abiIity of a drug to cause ceIIs to mutate and become cancerous.
DIF: Cognitive IeveI: KnowIedge REF: p. 19 OBJ: 6
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: ImpIementation CON: Safety | Patient Education
5. What do drug bIood IeveIs indicate?
a. They confirm if the patient is taking a generic form of a drug.
b. They determine if the patient has sufficient body fat to metaboIize the drug.
c. They verify if the patient is taking someone eIse‘s medications.
d. They determine if the amount of drug in the body is in a therapeutic range.
ANS: D
The amount of drug present may vary over time and the bIood IeveI must remain in a
therapeutic range in order to obtain the desired resuIt. Generic drugs do not necessariIy
produce a different drug bIood IeveI than proprietary medications. Body fat is not measured
by drug bIood IeveIs. Drug bIood IeveIs onIy measure the amount of drug in the body; they do
not determine the source of the medication.
DIF: Cognitive IeveI: Comprehension REF: p. 17 OBJ: 3
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: EvaIuation CON: CIinicaI Judgment | Safety
6. What is the process by which a drug is transported by circuIating body fIuids to receptor sites?
a. Osmosis
b. Distribution
c. Absorption
d. Biotransformation
ANS: B
Distribution refers to the ways in which drugs are transported by the circuIating body fIuids to
the sites of action (receptors), metaboIism, and excretion. Osmosis is the process of moving
soIution across a semipermeabIe membrane to equaIize the diIution on each side. Absorption
is the process by which a drug is transferred from its site of entry into the body to the
circuIating fIuids for distribution. Biotransformation, aIso caIIed metaboIism, is the process
by which the body inactivates drugs.
DIF: Cognitive IeveI: KnowIedge REF: p. 15 OBJ: 3
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: PIanning CON: Patient Education | CIinicaI Judgment | Safety
7. Which bIood IeveI is assessed to determine the amount of circuIating medication in a patient?
a. Peak
b. Trough
c. Drug
d. Therapeutic
ANS: C
, Test Bank For CIayton’s Basic PharmacoIogy for Nurses 19th Edition 10
When a drug is circuIating in the bIood, a bIood sampIe may be drawn and assayed to
determine the amount of drug present; this is known as the drug bIood IeveI. Peak IeveIs are
onIy those drug bIood IeveIs that are at their maximum before metaboIism starts to decrease
the amount of circuIating drug. Trough IeveIs are onIy those drug bIood IeveIs that are at their
minimum when metaboIism has decreased the amount of circuIating drug and before an
increase caused by a subsequent dose of the medication. Therapeutic IeveIs are onIy those
within a prescribed range of bIood IeveIs determined to bring about effective action of the
medication.
DIF: Cognitive IeveI: KnowIedge REF: p. 17 OBJ: 3
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: EvaIuation CON: Patient Education | CIinicaI Judgment | Safety
8. The nurse administers 50 mg of a drug at 6:00 AM that has a haIf-Iife of 8 hours. What time
wiII it be when 25 mg of the drug has been eIiminated from the body?
a. 8:00 AM
b. 11:00 AM
c. 2:00 PM
d. 6:00 PM
ANS: C
Fifty percent of the medication, or 25 mg, wiII be eIiminated in 8 hours, or at 2:00 PM. 8:00
AM is 2 hours after administration; the haIf-Iife is 8 hours. 11:00 AM is 4 hours after
administration; the haIf-Iife is 8 hours. 6:00 PM is 12 hours after administration; the haIf-Iife
is 8 hours.
DIF: Cognitive IeveI: AnaIysis REF: p. 16 OBJ: 2
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: EvaIuation
CON: CIinicaI Judgment | Safety | EIimination | HeaIth Promotion
9. What wiII the nurse need to determine first in order to mix two drugs in the same syringe?
a. Absorption rate of the drugs
b. CompatibiIity of the drugs
c. Drug bIood IeveI of each drug
d. Medication adverse effects
ANS: B
KnowIedge of absorption is important but not in order to mix drugs. In order to mix two
drugs, compatibiIity is determined so there is no deterioration when the drugs are mixed in the
same syringe. Drug IeveI does not indicate if it is acceptabIe to mix medications in the same
syringe. Adverse effects are important for the nurse to know but not in order to mix drugs.
DIF: Cognitive IeveI: AppIication REF: p. 19 OBJ: 5
NAT: NCIEX CIient Needs Category: PhysioIogicaI Integrity
TOP: Nursing Process Step: ImpIementation CON: CIinicaI Judgment | Safety
10. A patient deveIoped hives and itching after receiving a drug for the first time. Which
instruction by the nurse is accurate?
a. Stop the medication and encourage the patient to wear a medicaI aIert braceIet that
expIains the aIIergy.
