Whole MPP Class quizzes and tests 227
complete solutions Approved and
Verified by expert tutors.
Whole MPP Class quizzes and tests 227 complete solutions Approved and Verified by expert tutors.
What is the name of the glucose transporters found on skeletal muscle and fat cells - ANSWER GLUT4
What is the name of the polymer which is the stored form of glucose ? - ANSWER glycogen
GLUT4 is expressed in liver cells. - ANSWER False Liver cells do not express GLUT4 at their membrane.
Instead liver cells express a slightly different glucose transporter at their membrane named GLUT2.
The endocrine portion of the pancreas is made up of alpha cells and beta cells. What hormone is
produced and released by the beta cells of the pancreas? - ANSWER Insulin
What is the name of the peptide that is released from the pancreatic beta cells when insulin is released?
- ANSWER C-peptide
Which organ does not utilize fatty acids? - ANSWER Brain
Put the following steps involved in blood glucose regulation in order starting with having a glucose
containing meal. - ANSWER 1. Glucose is absorbed from the intestine to the blood
2. Blood glucose increases
3. pancreatic beta cells sense increased blood glucose
4. Insulin is released into the blood
5. insulin binds to insulin receptors on target cells
6. GLUT4 glucose transporters will take up glucose into skeletal muscle and fat cells
7. Blood glucose levels decrease
Match the following types of Diabetes mellitus to the pathological problem at the cellular level. -
ANSWER Diabetes mellitus type 1
,Whole MPP Class quizzes and tests 227
complete solutions Approved and
Verified by expert tutors.
inability of the pancreatic beta cells to secrete insulin
Diabetes mellitus type 2
target cells have less sensitive or resistant insulin receptors
GLUT4 transports glucose from the blood into liver cells. - ANSWER False.
explanation: Correct, GLUT4 transports glucose from the blood to skeletal muscle and fat cells.
Glucagon is secreted by pancreatic______ cells when blood glucose levels ________ . - ANSWER 1. alpha
2. decrease
During a glucose challenge, would a patient with type I diabetes secrete more or less insulin compared
to normal? - ANSWER less
If a type I diabetic gave them self an insulin injection just after a meal, their blood levels of C-peptide
should be elevated? - ANSWER False
explanation: When drug companies produce insulin they do not include C-peptide. Thus C-peptide
should be near zero. The C-peptide comes from when the body's beta cells produce the proinsulin and
then convert it to insulin.
The drug SU causes pancreatic beta cells to secrete more insulin into the blood than normal as a way to
combat insulin receptor insensitivity in type II diabetics. Do you expect a patient's blood C-peptide levels
to be higher or lower than normal if they are taking SU? - ANSWER higher
Where are SGLT co transporters found? - ANSWER intestine and kidney tubule
What 2 molecules do the SGLTs transport? - ANSWER glucose and sodium
When blood glucose levels increase, more glucose gets filtered to the kidney tubule? - ANSWER true
,Whole MPP Class quizzes and tests 227
complete solutions Approved and
Verified by expert tutors.
When will glucose show up in the urine? - ANSWER only when blood glucose levels get very high and
saturate the SGLTs
Select the false statement about GLUT4 transporters. - ANSWER They are found at the membrane of
skeletal muscle all the time
true statements:
GLUT4s are important to take up excess glucose from the blood to fat and muscle cells
GLUT4s are the glucose transports in fat cells
Insulin binding to insulin receptors allows GLUT4s to transport glucose into muscle cells
In the absence of insulin, GLUT4s are found inside resting muscle cells
Where will GLUT4 transporters be located, inside or at the membrane, of resting skeletal muscle in the
fasted state? - ANSWER inside
The hormone [_____________] will signal liver cells to breakdown glycogen to glucose-6-phosphate. -
ANSWER glucagon
The ___________transporter in the nephron tubule allows for the reabsorption of glucose back to the
blood. - ANSWER SGLT2
The urine is _______ reached when the blood glucose levels rise and the SGLT2 transporter becomes
_______ - ANSWER 1. threshold
2. saturated
According to the plot below, what is the glucose concentration that saturates the SGLT2?
According to the same plot, how much glucose will be in the urine at a blood glucose concentration of
12? - ANSWER 5 and 7
, Whole MPP Class quizzes and tests 227
complete solutions Approved and
Verified by expert tutors.
Which answer is false regarding the transport of glucose across cell membranes? - ANSWER The
transport of glucose from the nephron tubule back to the blood causes water to be excreted via osmosis
true statements:
Glucose moves into cells through the GLUT4 transporter down its concentration gradient
The SGLT2 is an example of cotransport
The SGLT2 utilizes secondary active transport
Select all the options below that would result in elevated blood glucose level. - ANSWER 1. Insensitivity
of the insulin receptors
2. A glucagon-secreting tumor in the pancreatic alpha cells
false statements:
Inhibiting the breakdown of liver glycogen
Inhibition of the SGLT2 transporter in the kidney tubule
An insulin-secreting tumor in the pancreatic beta cells
Glucose uptake into resting skeletal muscle cells (select all that are correct) - ANSWER 1. Is insulin-
dependent.
2. Occurs via facilitated diffusion
false statements:
1. Results in the breakdown of glycogen.
2. Is enhanced in people with type 1 diabetes mellitus.
3. Primarily requires the sodium glucose linked transporter (SGLT2).
complete solutions Approved and
Verified by expert tutors.
Whole MPP Class quizzes and tests 227 complete solutions Approved and Verified by expert tutors.
What is the name of the glucose transporters found on skeletal muscle and fat cells - ANSWER GLUT4
What is the name of the polymer which is the stored form of glucose ? - ANSWER glycogen
GLUT4 is expressed in liver cells. - ANSWER False Liver cells do not express GLUT4 at their membrane.
Instead liver cells express a slightly different glucose transporter at their membrane named GLUT2.
The endocrine portion of the pancreas is made up of alpha cells and beta cells. What hormone is
produced and released by the beta cells of the pancreas? - ANSWER Insulin
What is the name of the peptide that is released from the pancreatic beta cells when insulin is released?
- ANSWER C-peptide
Which organ does not utilize fatty acids? - ANSWER Brain
Put the following steps involved in blood glucose regulation in order starting with having a glucose
containing meal. - ANSWER 1. Glucose is absorbed from the intestine to the blood
2. Blood glucose increases
3. pancreatic beta cells sense increased blood glucose
4. Insulin is released into the blood
5. insulin binds to insulin receptors on target cells
6. GLUT4 glucose transporters will take up glucose into skeletal muscle and fat cells
7. Blood glucose levels decrease
Match the following types of Diabetes mellitus to the pathological problem at the cellular level. -
ANSWER Diabetes mellitus type 1
,Whole MPP Class quizzes and tests 227
complete solutions Approved and
Verified by expert tutors.
inability of the pancreatic beta cells to secrete insulin
Diabetes mellitus type 2
target cells have less sensitive or resistant insulin receptors
GLUT4 transports glucose from the blood into liver cells. - ANSWER False.
explanation: Correct, GLUT4 transports glucose from the blood to skeletal muscle and fat cells.
Glucagon is secreted by pancreatic______ cells when blood glucose levels ________ . - ANSWER 1. alpha
2. decrease
During a glucose challenge, would a patient with type I diabetes secrete more or less insulin compared
to normal? - ANSWER less
If a type I diabetic gave them self an insulin injection just after a meal, their blood levels of C-peptide
should be elevated? - ANSWER False
explanation: When drug companies produce insulin they do not include C-peptide. Thus C-peptide
should be near zero. The C-peptide comes from when the body's beta cells produce the proinsulin and
then convert it to insulin.
The drug SU causes pancreatic beta cells to secrete more insulin into the blood than normal as a way to
combat insulin receptor insensitivity in type II diabetics. Do you expect a patient's blood C-peptide levels
to be higher or lower than normal if they are taking SU? - ANSWER higher
Where are SGLT co transporters found? - ANSWER intestine and kidney tubule
What 2 molecules do the SGLTs transport? - ANSWER glucose and sodium
When blood glucose levels increase, more glucose gets filtered to the kidney tubule? - ANSWER true
,Whole MPP Class quizzes and tests 227
complete solutions Approved and
Verified by expert tutors.
When will glucose show up in the urine? - ANSWER only when blood glucose levels get very high and
saturate the SGLTs
Select the false statement about GLUT4 transporters. - ANSWER They are found at the membrane of
skeletal muscle all the time
true statements:
GLUT4s are important to take up excess glucose from the blood to fat and muscle cells
GLUT4s are the glucose transports in fat cells
Insulin binding to insulin receptors allows GLUT4s to transport glucose into muscle cells
In the absence of insulin, GLUT4s are found inside resting muscle cells
Where will GLUT4 transporters be located, inside or at the membrane, of resting skeletal muscle in the
fasted state? - ANSWER inside
The hormone [_____________] will signal liver cells to breakdown glycogen to glucose-6-phosphate. -
ANSWER glucagon
The ___________transporter in the nephron tubule allows for the reabsorption of glucose back to the
blood. - ANSWER SGLT2
The urine is _______ reached when the blood glucose levels rise and the SGLT2 transporter becomes
_______ - ANSWER 1. threshold
2. saturated
According to the plot below, what is the glucose concentration that saturates the SGLT2?
According to the same plot, how much glucose will be in the urine at a blood glucose concentration of
12? - ANSWER 5 and 7
, Whole MPP Class quizzes and tests 227
complete solutions Approved and
Verified by expert tutors.
Which answer is false regarding the transport of glucose across cell membranes? - ANSWER The
transport of glucose from the nephron tubule back to the blood causes water to be excreted via osmosis
true statements:
Glucose moves into cells through the GLUT4 transporter down its concentration gradient
The SGLT2 is an example of cotransport
The SGLT2 utilizes secondary active transport
Select all the options below that would result in elevated blood glucose level. - ANSWER 1. Insensitivity
of the insulin receptors
2. A glucagon-secreting tumor in the pancreatic alpha cells
false statements:
Inhibiting the breakdown of liver glycogen
Inhibition of the SGLT2 transporter in the kidney tubule
An insulin-secreting tumor in the pancreatic beta cells
Glucose uptake into resting skeletal muscle cells (select all that are correct) - ANSWER 1. Is insulin-
dependent.
2. Occurs via facilitated diffusion
false statements:
1. Results in the breakdown of glycogen.
2. Is enhanced in people with type 1 diabetes mellitus.
3. Primarily requires the sodium glucose linked transporter (SGLT2).
