ONS Chemotherapy Immunotherapy
Certificate
Define neoadjuvant therapy - CORRECT ANSWERS-Treatment is given prior to surgery
to shrink the tumor
Define adjuvant therapy - CORRECT ANSWERS-Additional cancer treatment given
after the primary treatment to lower the risk that the cancer reoccur
3 subcategories of alkylating agents: - CORRECT ANSWERS-1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed alkylating
agents as they work similarly)
3. Nitrosoureas
Common alkylating agents: - CORRECT ANSWERS-Cyclophosphamide (Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda)
Common platinum-based agents: - CORRECT ANSWERS-Cisplatin (Platinol)
Carboplatin (Paraplatin)
What is unique about nitrosoureas agents? - CORRECT ANSWERS-Able to cross the
blood-brain barrier; can be effective in treating some brain tumors
Common nitrosoureas agents: - CORRECT ANSWERS-Carmustine (BiCNU)
Lomustine (CeeNu)
Streptozocin (Zanosar)
Hypersensitivity can occur with late doses of: - CORRECT ANSWERS-Carboplatin
These agents are typically categorized as highly emetogenic: - CORRECT ANSWERS-
1. Alkylating agents
2. Nitrosoureas
, Pre-administration labs for alkylating agents and nitrosoureas: - CORRECT ANSWERS-
BUN
Creatinine
CBC w/ diff
What is the medication Mesna used for? - CORRECT ANSWERS-Bladder protectant
with administration of cyclophosphamide or ifosfamide
Instruct pts receiving ________ to avoid exposure to cold air and consuming cold fluids
for 3-4 days following treatment - CORRECT ANSWERS-Oxaliplatin
How do antimetabolites function? - CORRECT ANSWERS-By blocking DNA and RNA
growth by interfering with enzymes needed for normal cell metabolism
Antimetabolites work in the ___ phase. - CORRECT ANSWERS-S
Common side effects of antimetabolites: - CORRECT ANSWERS-Myelosuppression
GI toxicities
Photosensitivity
Hand-foot syndrome
Common antimetabolite drugs: - CORRECT ANSWERS-Azacitidine
Capecitabine
5-FU
Cytarabine
Decitabine
Methotrexate
The institute for Safe Medication Practices recommends what route of administration for
vincristine? - CORRECT ANSWERS-IV piggyback via gravity
Anthracycline antitumor abx work by: - CORRECT ANSWERS-Interfering with enzymes
necessary for DNA to replicate in ALL phases of the cell cycle
The two major classifications of antitumor antibiotics are: - CORRECT ANSWERS-
Anthracyclines
Non-anthracyclines
Common anthracycline antitumor abx: - CORRECT ANSWERS-Daunorubicin
Doxorubicin
Epirubicin
Idarubicin
The antitumor abx ___________ is not an anthracycline, but has anthracycline-type
properties. - CORRECT ANSWERS-Mitoxantrone
Certificate
Define neoadjuvant therapy - CORRECT ANSWERS-Treatment is given prior to surgery
to shrink the tumor
Define adjuvant therapy - CORRECT ANSWERS-Additional cancer treatment given
after the primary treatment to lower the risk that the cancer reoccur
3 subcategories of alkylating agents: - CORRECT ANSWERS-1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed alkylating
agents as they work similarly)
3. Nitrosoureas
Common alkylating agents: - CORRECT ANSWERS-Cyclophosphamide (Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda)
Common platinum-based agents: - CORRECT ANSWERS-Cisplatin (Platinol)
Carboplatin (Paraplatin)
What is unique about nitrosoureas agents? - CORRECT ANSWERS-Able to cross the
blood-brain barrier; can be effective in treating some brain tumors
Common nitrosoureas agents: - CORRECT ANSWERS-Carmustine (BiCNU)
Lomustine (CeeNu)
Streptozocin (Zanosar)
Hypersensitivity can occur with late doses of: - CORRECT ANSWERS-Carboplatin
These agents are typically categorized as highly emetogenic: - CORRECT ANSWERS-
1. Alkylating agents
2. Nitrosoureas
, Pre-administration labs for alkylating agents and nitrosoureas: - CORRECT ANSWERS-
BUN
Creatinine
CBC w/ diff
What is the medication Mesna used for? - CORRECT ANSWERS-Bladder protectant
with administration of cyclophosphamide or ifosfamide
Instruct pts receiving ________ to avoid exposure to cold air and consuming cold fluids
for 3-4 days following treatment - CORRECT ANSWERS-Oxaliplatin
How do antimetabolites function? - CORRECT ANSWERS-By blocking DNA and RNA
growth by interfering with enzymes needed for normal cell metabolism
Antimetabolites work in the ___ phase. - CORRECT ANSWERS-S
Common side effects of antimetabolites: - CORRECT ANSWERS-Myelosuppression
GI toxicities
Photosensitivity
Hand-foot syndrome
Common antimetabolite drugs: - CORRECT ANSWERS-Azacitidine
Capecitabine
5-FU
Cytarabine
Decitabine
Methotrexate
The institute for Safe Medication Practices recommends what route of administration for
vincristine? - CORRECT ANSWERS-IV piggyback via gravity
Anthracycline antitumor abx work by: - CORRECT ANSWERS-Interfering with enzymes
necessary for DNA to replicate in ALL phases of the cell cycle
The two major classifications of antitumor antibiotics are: - CORRECT ANSWERS-
Anthracyclines
Non-anthracyclines
Common anthracycline antitumor abx: - CORRECT ANSWERS-Daunorubicin
Doxorubicin
Epirubicin
Idarubicin
The antitumor abx ___________ is not an anthracycline, but has anthracycline-type
properties. - CORRECT ANSWERS-Mitoxantrone
