PHCH 667-Exam 2 Questions with Complete
Solutions
which of the following methods/assays is not used to determine creatinine serum
concentration?
a) HPLC method (directly detect and quantify creatinine upon LC separation)
b) immunoassay (detect using antibodies against creatinine)
c) enzymatic assay (reaction of creatinine with creatine iminohydrolase)
d) Jaffe reaction (reaction of creatinine with picric acid to form a red-orange complex) b)
immunoassay (detect using antibodies against creatinine)
BUN:SCr ratio can be used to determine the cause of acute kidney injury as prerenal or
intrarenal. which of the following lab results suggest intrinsic renal damage?
a) BUN:SCr <10 and both BUN and SCr are elevated than normal
b) BUN:SCr < 10 and both BUN and SCr are lower than normal
c) BUN:SCr >20 and both BUN and SCr are elevated than normal
d) BUN:SCr >20 and both BUN and SCr are lower than normal a) BUN:SCr <10 and both
BUN and SCr are elevated than normal
,During dipstick urinanalysis, normal urine should not contain the following substances except
for?
a) sodium and potassium
b) protein
c) albumin and hemoglobin
d) glucose a) sodium and potassium
which of the following would elevate serum creatinine concentration?
a) dehydration
b) renal dysfunction caused by aminoglycosides
c) urinary tract obstruction
d) all are correct d) all are correct
True or false: urea is mainly produced in the liver to remove toxic ammonia. Although urea is
almost completely filtered by glomerulus, approximately 50% of the filtered urea is re-absorbed
by kidney tubules. True
, Drugs that inhibit tubular secretion of creatinine can cause false postitive result for CKD, due to
an elevated serum creatinine concentration without any damage to renal function. These drugs
include:
a) acetaminophen and ibuprofen
b) cimetidine and probenecid
c) fexofenadine and loratadine
d) warfarin and sildenafil b) cimetidine and probenecid
A patient (11 years old) is prescribed imipenem IV for a gram-negative bacterial infection.
Imipenem overdose can cause seizure and other CNS adverse effects, especially in patients with
CNS disorders and/or compromised renal function. Imipenem dosage needs to be adjusted
based on calculated CrCL or GFR. Which formula would be most appropriate in this case to
calculate CrCl or GFR?
a) MDRD formula
b) Schwartz formula or Counahan-Barratt formula
c) 24-hour urine collection method
d) cockcroft-gault equation b) schwartz formula or counahan-barratt formula
A selective bacteria growth medium works by
Solutions
which of the following methods/assays is not used to determine creatinine serum
concentration?
a) HPLC method (directly detect and quantify creatinine upon LC separation)
b) immunoassay (detect using antibodies against creatinine)
c) enzymatic assay (reaction of creatinine with creatine iminohydrolase)
d) Jaffe reaction (reaction of creatinine with picric acid to form a red-orange complex) b)
immunoassay (detect using antibodies against creatinine)
BUN:SCr ratio can be used to determine the cause of acute kidney injury as prerenal or
intrarenal. which of the following lab results suggest intrinsic renal damage?
a) BUN:SCr <10 and both BUN and SCr are elevated than normal
b) BUN:SCr < 10 and both BUN and SCr are lower than normal
c) BUN:SCr >20 and both BUN and SCr are elevated than normal
d) BUN:SCr >20 and both BUN and SCr are lower than normal a) BUN:SCr <10 and both
BUN and SCr are elevated than normal
,During dipstick urinanalysis, normal urine should not contain the following substances except
for?
a) sodium and potassium
b) protein
c) albumin and hemoglobin
d) glucose a) sodium and potassium
which of the following would elevate serum creatinine concentration?
a) dehydration
b) renal dysfunction caused by aminoglycosides
c) urinary tract obstruction
d) all are correct d) all are correct
True or false: urea is mainly produced in the liver to remove toxic ammonia. Although urea is
almost completely filtered by glomerulus, approximately 50% of the filtered urea is re-absorbed
by kidney tubules. True
, Drugs that inhibit tubular secretion of creatinine can cause false postitive result for CKD, due to
an elevated serum creatinine concentration without any damage to renal function. These drugs
include:
a) acetaminophen and ibuprofen
b) cimetidine and probenecid
c) fexofenadine and loratadine
d) warfarin and sildenafil b) cimetidine and probenecid
A patient (11 years old) is prescribed imipenem IV for a gram-negative bacterial infection.
Imipenem overdose can cause seizure and other CNS adverse effects, especially in patients with
CNS disorders and/or compromised renal function. Imipenem dosage needs to be adjusted
based on calculated CrCL or GFR. Which formula would be most appropriate in this case to
calculate CrCl or GFR?
a) MDRD formula
b) Schwartz formula or Counahan-Barratt formula
c) 24-hour urine collection method
d) cockcroft-gault equation b) schwartz formula or counahan-barratt formula
A selective bacteria growth medium works by
