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to accompany
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Psychopharmacology, fourth Edition Wi Wi
Meyer • Quenzer Wi Wi
Chapter 1: Principles of Pharmacology
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Multiple Choice Wi
1. refer(s) to specific molecular changes that occur when a drug binds to
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a particular target site or receptor, while
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are the resulting widespread alterations in function.
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a. Drug action; therapeutic effects
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b. Side effects; drug effects
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c. Therapeutic effects; side effects Wi Wi Wi
d. Drug action; drug effects
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Answer: d Wi
Textbook Reference: Pharmacology: The Science of Drug Action
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2. After drug administration has occurred, the amount of drug in the blood that is fr
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ee to bind at specific target sites is referred to as
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a. the therapeutic dose.
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b. first-pass effects. Wi
c. bioavailability.
d. ED50.
Answer: c Wi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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3. The specific molecular changes that occur when a drug binds to a particular target
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site or receptor are referred to as
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a. drug effects. Wi
b. drug action. Wi
c. side effects. Wi
d. placebo effects. Wi
Answer: b Wi
Textbook Reference: Pharmacology: The Science of Drug Action
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4. Which of the following is not a possible explanation for placebo effects?
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a. Pavlovian conditioning Wi
b. Genetic variation Wi
c. Drug competition Wi
d. Expectation of outcome Wi Wi
Answer: c Wi
Textbook Reference: Pharmacology: The Science of Drug Action
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Page 1 of 247
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,5. The administration of oxytocin has been proposed as a treatment for autism. Wi Wi Wi Wi Wi Wi Wi Wi Wi Wi
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c Wi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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6. Which factor does not affect the pharmacokinetics of a drug?
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a. Route of administration
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b. Lipid solubility
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c. Depot binding Wi
d. Drug action Wi
Answer: d Wi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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7. First-pass metabolism occurs when drugs are taken
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a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a Wi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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8. The area postrema is one area in the brain where the
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a. cerebrospinal fluid Wi
b. blood–brain barrier Wi
c. choroid plexus Wi
d. phospholipid membrane Wi
Answer: b Wi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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9. First-pass metabolism occurs with orally administered drugs because
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a. their absorption is slowed by food.
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b. drugs absorbed into the bloodstream from the stomach go to the liver on the w
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ay to general circulation.
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c. drugs must first survive the acidic environment of the stomach.
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d. salivary enzymes in the mouth begin the process of metabolism.
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Answer: b Wi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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10. Toxic substances in the blood trigger a vomiting response by activating the
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a. blood–brain barrier. Wi
b. choroid plexus. Wi
c. area postrema.
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d. median eminence. Wi
Page 2 of 247
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, Answer: c Wi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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11. Drugs administered _ Wi have the most rapid onset of action. Wi Wi Wi Wi Wi Wi Wi
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d Wi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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12. Ionization of a drug depends on the
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of the drug.
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a. pH; pKa
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b. pKa; pHWi
c. concentration; lipid solubility Wi Wi
d. pH; concentration
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Answer: a Wi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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13. The absorption of a drug depends on all of the following except
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a. lipid solubility.
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b. ionization.
c. body temperature.
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d. the concentration of the drug.
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Answer: c Wi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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14. Drugs that are Wi should be avoided by women of childbearing age.
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a. teratogenic
b. able to cross the placental barrier
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c. psychoactive
d. highly lipid-soluble
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Answer: a Wi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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15. Agents that induce developmental abnormalities in a fetus are known as
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a. psychoactive drugs. Wi
b. illicit drugs.
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c. teratogens.
d. placental drugs. Wi
Answer: c Wi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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16. Depot binding is said to occur when drugs
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a. bind to their target sites.
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Page 3 of 247
Wi Wi Wi
to accompany
Wi
Psychopharmacology, fourth Edition Wi Wi
Meyer • Quenzer Wi Wi
Chapter 1: Principles of Pharmacology
Wi Wi Wi Wi
Multiple Choice Wi
1. refer(s) to specific molecular changes that occur when a drug binds to
Wi Wi Wi Wi Wi Wi Wi Wi Wi Wi Wi Wi
a particular target site or receptor, while
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are the resulting widespread alterations in function.
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a. Drug action; therapeutic effects
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b. Side effects; drug effects
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c. Therapeutic effects; side effects Wi Wi Wi
d. Drug action; drug effects
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Answer: d Wi
Textbook Reference: Pharmacology: The Science of Drug Action
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2. After drug administration has occurred, the amount of drug in the blood that is fr
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ee to bind at specific target sites is referred to as
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a. the therapeutic dose.
Wi Wi
b. first-pass effects. Wi
c. bioavailability.
d. ED50.
Answer: c Wi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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3. The specific molecular changes that occur when a drug binds to a particular target
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site or receptor are referred to as
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a. drug effects. Wi
b. drug action. Wi
c. side effects. Wi
d. placebo effects. Wi
Answer: b Wi
Textbook Reference: Pharmacology: The Science of Drug Action
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4. Which of the following is not a possible explanation for placebo effects?
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a. Pavlovian conditioning Wi
b. Genetic variation Wi
c. Drug competition Wi
d. Expectation of outcome Wi Wi
Answer: c Wi
Textbook Reference: Pharmacology: The Science of Drug Action
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Page 1 of 247
Wi Wi Wi
,5. The administration of oxytocin has been proposed as a treatment for autism. Wi Wi Wi Wi Wi Wi Wi Wi Wi Wi
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c Wi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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6. Which factor does not affect the pharmacokinetics of a drug?
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a. Route of administration
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b. Lipid solubility
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c. Depot binding Wi
d. Drug action Wi
Answer: d Wi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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7. First-pass metabolism occurs when drugs are taken
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a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a Wi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
Wi Wi Wi Wi Wi Wi
8. The area postrema is one area in the brain where the
Wi Wi is not complete.
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a. cerebrospinal fluid Wi
b. blood–brain barrier Wi
c. choroid plexus Wi
d. phospholipid membrane Wi
Answer: b Wi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
Wi Wi Wi Wi Wi Wi
9. First-pass metabolism occurs with orally administered drugs because
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a. their absorption is slowed by food.
Wi Wi Wi Wi Wi
b. drugs absorbed into the bloodstream from the stomach go to the liver on the w
Wi Wi Wi Wi Wi Wi Wi Wi Wi Wi Wi Wi Wi Wi
ay to general circulation.
Wi Wi Wi
c. drugs must first survive the acidic environment of the stomach.
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d. salivary enzymes in the mouth begin the process of metabolism.
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Answer: b Wi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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10. Toxic substances in the blood trigger a vomiting response by activating the
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a. blood–brain barrier. Wi
b. choroid plexus. Wi
c. area postrema.
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d. median eminence. Wi
Page 2 of 247
Wi Wi Wi
, Answer: c Wi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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11. Drugs administered _ Wi have the most rapid onset of action. Wi Wi Wi Wi Wi Wi Wi
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d Wi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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12. Ionization of a drug depends on the
Wi of the solution and the
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of the drug.
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a. pH; pKa
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b. pKa; pHWi
c. concentration; lipid solubility Wi Wi
d. pH; concentration
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Answer: a Wi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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13. The absorption of a drug depends on all of the following except
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a. lipid solubility.
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b. ionization.
c. body temperature.
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d. the concentration of the drug.
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Answer: c Wi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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14. Drugs that are Wi should be avoided by women of childbearing age.
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a. teratogenic
b. able to cross the placental barrier
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c. psychoactive
d. highly lipid-soluble
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Answer: a Wi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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15. Agents that induce developmental abnormalities in a fetus are known as
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a. psychoactive drugs. Wi
b. illicit drugs.
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c. teratogens.
d. placental drugs. Wi
Answer: c Wi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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16. Depot binding is said to occur when drugs
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a. bind to their target sites.
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Page 3 of 247
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