, Test Bank
g
to gaccompany
Psychopharmacology, Third Editiong g
Meyer g• gQuenzer
Chapter 1: Principles of Pharmacology
g g g g
Multiple gChoice
1. refer(s) gto gspecific gmolecular gchanges gthat goccur gwhen ga gdrug gbinds gto ga
gparticular gtarget gsite gor greceptor, gwhile are gthe gresulting gwidespread galterations
gin gfunction.
a. Drug gaction; gtherapeutic geffects
b. Side geffects; gdrug geffects
c. Therapeutic geffects; gside geffects
d. Drug gaction; gdrug geffects
Answer: gd
Textbook gReference: gPharmacology: gThe gScience gof gDrug gAction
2. After gdrug gadministration ghas goccurred, gthe gamount gof gdrug gin gthe gblood gthat gis gfree
gto gbind gat gspecific gtarget gsites gis greferred gto gas
a. the gtherapeutic gdose.
b. first-pass geffects.
c. bioavailability.
d. ED50.
Answer: gc
Textbook gReference: gPharmacokinetic gFactors gDetermining gDrug gAction
3. The gspecific gmolecular gchanges gthat goccur gwhen ga gdrug gbinds gto ga gparticular gtarget
gsite gor greceptor gare greferred gto gas
a. drug geffects.
b. drug gaction.
c. side geffects.
d. placebo geffects.
Answer: gb
Textbook gReference: gPharmacology: gThe gScience gof gDrug gAction
4. Which gof gthe gfollowing gis gnot ga gpossible gexplanation gfor gplacebo geffects?
a. Pavlovian gconditioning
b. Genetic gvariation
c. Drug gcompetition
d. Expectation gof goutcome
Answer: gc
Textbook gReference: gPharmacology: gThe gScience gof gDrug gAction
Page 1 of 247
,5. The administration gof goxytocin ghas gbeen gproposed gas ga gtreatment gfor gautism.
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: gc
Textbook gReference: gPharmacokinetic gFactors gDetermining gDrug gAction
6. Which gfactor gdoes gnot gaffect gthe gpharmacokinetics gof ga gdrug?
a. Route gof gadministration
b. Lipid gsolubility
c. Depot gbinding
d. Drug gaction
Answer: gd
Textbook gReference: gPharmacokinetic gFactors gDetermining gDrug gAction
7. First-pass gmetabolism goccurs gwhen gdrugs gare gtaken
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: ga
Textbook gReference: gPharmacokinetic gFactors gDetermining gDrug gAction
8. The garea gpostrema gis gone garea gin gthe gbrain gwhere gthe is gnot gcomplete.
a. cerebrospinal gfluid
b. blood–brain gbarrier
c. choroid gplexus
d. phospholipid gmembrane
Answer: gb
Textbook gReference: gPharmacokinetic gFactors gDetermining gDrug gAction
9. First-pass gmetabolism goccurs gwith gorally gadministered gdrugs gbecause
a. their gabsorption gis gslowed gby gfood.
b. drugs gabsorbed ginto gthe gbloodstream gfrom gthe gstomach ggo gto gthe gliver gon gthe gway
gto ggeneral gcirculation.
c. drugs gmust gfirst gsurvive gthe gacidic genvironment gof gthe gstomach.
d. salivary genzymes gin gthe gmouth gbegin gthe gprocess gof gmetabolism.
Answer: gb
Textbook gReference: gPharmacokinetic gFactors gDetermining gDrug gAction
10. Toxic gsubstances gin gthe gblood gtrigger ga gvomiting gresponse gby gactivating gthe
a. blood–brain gbarrier.
b. choroid gplexus.
c. area gpostrema.
d. median geminence.
Page 2 of 247
, Answer: gc
Textbook gReference: gPharmacokinetic gFactors gDetermining gDrug gAction
11. Drugs gadministered g_ have gthe gmost grapid gonset gof gaction.
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: gd
Textbook gReference: gPharmacokinetic gFactors gDetermining gDrug gAction
12. Ionization gof ga gdrug gdepends gon gthe of gthe gsolution gand gthe of gthe
gdrug.
a. pH; gpKa
b. pKa; gpH
c. concentration; glipid gsolubility
d. pH; gconcentration
Answer: ga
Textbook gReference: gPharmacokinetic gFactors gDetermining gDrug gAction
13. The gabsorption gof ga gdrug gdepends gon gall gof gthe gfollowing gexcept
a. lipid gsolubility.
b. ionization.
c. body gtemperature.
d. the gconcentration gof gthe gdrug.
Answer: gc
Textbook gReference: gPharmacokinetic gFactors gDetermining gDrug gAction
14. Drugs gthat gare should gbe gavoided gby gwomen gof gchildbearing gage.
a. teratogenic
b. able gto gcross gthe gplacental gbarrier
c. psychoactive
d. highly glipid-soluble
Answer: ga
Textbook gReference: gPharmacokinetic gFactors gDetermining gDrug gAction
15. Agents gthat ginduce gdevelopmental gabnormalities gin ga gfetus gare gknown gas
a. psychoactive gdrugs.
b. illicit gdrugs.
c. teratogens.
d. placental gdrugs.
Answer: gc
Textbook gReference: gPharmacokinetic gFactors gDetermining gDrug gAction
16. Depot gbinding gis gsaid gto goccur gwhen gdrugs
a. bind gto gtheir gtarget gsites.
Page 3 of 247
g
to gaccompany
Psychopharmacology, Third Editiong g
Meyer g• gQuenzer
Chapter 1: Principles of Pharmacology
g g g g
Multiple gChoice
1. refer(s) gto gspecific gmolecular gchanges gthat goccur gwhen ga gdrug gbinds gto ga
gparticular gtarget gsite gor greceptor, gwhile are gthe gresulting gwidespread galterations
gin gfunction.
a. Drug gaction; gtherapeutic geffects
b. Side geffects; gdrug geffects
c. Therapeutic geffects; gside geffects
d. Drug gaction; gdrug geffects
Answer: gd
Textbook gReference: gPharmacology: gThe gScience gof gDrug gAction
2. After gdrug gadministration ghas goccurred, gthe gamount gof gdrug gin gthe gblood gthat gis gfree
gto gbind gat gspecific gtarget gsites gis greferred gto gas
a. the gtherapeutic gdose.
b. first-pass geffects.
c. bioavailability.
d. ED50.
Answer: gc
Textbook gReference: gPharmacokinetic gFactors gDetermining gDrug gAction
3. The gspecific gmolecular gchanges gthat goccur gwhen ga gdrug gbinds gto ga gparticular gtarget
gsite gor greceptor gare greferred gto gas
a. drug geffects.
b. drug gaction.
c. side geffects.
d. placebo geffects.
Answer: gb
Textbook gReference: gPharmacology: gThe gScience gof gDrug gAction
4. Which gof gthe gfollowing gis gnot ga gpossible gexplanation gfor gplacebo geffects?
a. Pavlovian gconditioning
b. Genetic gvariation
c. Drug gcompetition
d. Expectation gof goutcome
Answer: gc
Textbook gReference: gPharmacology: gThe gScience gof gDrug gAction
Page 1 of 247
,5. The administration gof goxytocin ghas gbeen gproposed gas ga gtreatment gfor gautism.
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: gc
Textbook gReference: gPharmacokinetic gFactors gDetermining gDrug gAction
6. Which gfactor gdoes gnot gaffect gthe gpharmacokinetics gof ga gdrug?
a. Route gof gadministration
b. Lipid gsolubility
c. Depot gbinding
d. Drug gaction
Answer: gd
Textbook gReference: gPharmacokinetic gFactors gDetermining gDrug gAction
7. First-pass gmetabolism goccurs gwhen gdrugs gare gtaken
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: ga
Textbook gReference: gPharmacokinetic gFactors gDetermining gDrug gAction
8. The garea gpostrema gis gone garea gin gthe gbrain gwhere gthe is gnot gcomplete.
a. cerebrospinal gfluid
b. blood–brain gbarrier
c. choroid gplexus
d. phospholipid gmembrane
Answer: gb
Textbook gReference: gPharmacokinetic gFactors gDetermining gDrug gAction
9. First-pass gmetabolism goccurs gwith gorally gadministered gdrugs gbecause
a. their gabsorption gis gslowed gby gfood.
b. drugs gabsorbed ginto gthe gbloodstream gfrom gthe gstomach ggo gto gthe gliver gon gthe gway
gto ggeneral gcirculation.
c. drugs gmust gfirst gsurvive gthe gacidic genvironment gof gthe gstomach.
d. salivary genzymes gin gthe gmouth gbegin gthe gprocess gof gmetabolism.
Answer: gb
Textbook gReference: gPharmacokinetic gFactors gDetermining gDrug gAction
10. Toxic gsubstances gin gthe gblood gtrigger ga gvomiting gresponse gby gactivating gthe
a. blood–brain gbarrier.
b. choroid gplexus.
c. area gpostrema.
d. median geminence.
Page 2 of 247
, Answer: gc
Textbook gReference: gPharmacokinetic gFactors gDetermining gDrug gAction
11. Drugs gadministered g_ have gthe gmost grapid gonset gof gaction.
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: gd
Textbook gReference: gPharmacokinetic gFactors gDetermining gDrug gAction
12. Ionization gof ga gdrug gdepends gon gthe of gthe gsolution gand gthe of gthe
gdrug.
a. pH; gpKa
b. pKa; gpH
c. concentration; glipid gsolubility
d. pH; gconcentration
Answer: ga
Textbook gReference: gPharmacokinetic gFactors gDetermining gDrug gAction
13. The gabsorption gof ga gdrug gdepends gon gall gof gthe gfollowing gexcept
a. lipid gsolubility.
b. ionization.
c. body gtemperature.
d. the gconcentration gof gthe gdrug.
Answer: gc
Textbook gReference: gPharmacokinetic gFactors gDetermining gDrug gAction
14. Drugs gthat gare should gbe gavoided gby gwomen gof gchildbearing gage.
a. teratogenic
b. able gto gcross gthe gplacental gbarrier
c. psychoactive
d. highly glipid-soluble
Answer: ga
Textbook gReference: gPharmacokinetic gFactors gDetermining gDrug gAction
15. Agents gthat ginduce gdevelopmental gabnormalities gin ga gfetus gare gknown gas
a. psychoactive gdrugs.
b. illicit gdrugs.
c. teratogens.
d. placental gdrugs.
Answer: gc
Textbook gReference: gPharmacokinetic gFactors gDetermining gDrug gAction
16. Depot gbinding gis gsaid gto goccur gwhen gdrugs
a. bind gto gtheir gtarget gsites.
Page 3 of 247
