NR668 Week 4 Psychopharmacology Questions and Correct Answers/ Latest Update / Already Graded

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NR668 Week 4 Psychopharmacology
Questions and Correct Answers/ Latest
Update / Already Graded
Pharmacodynamics

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Ans: How the drug effects the body


-therapeutic vs. side effects


• Is it stimulating?


• Is it depressing?


• Does it block something?


-Onset of action


• Route, Dosage


-Duration of action


• Redistribution rate, metabolism rate and excretion rate


-Mechanism of action


• Drugs simply speed up or slow down what is already occurring in the

body


-Efficacy


• (Intrinsic activity) After binding, the drugs capacity to cause an effect


-Potency


• The amount of a drug needed to produce a given effect

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efficacy examples


Ans: -Agonist (Efficacy = 100)


-Partial Agonist (Efficacy = > 0 < 100)


-Antagonist (Efficacy = 0.0)


-Inverse Agonist (Efficacy = < 0)




Agonist:


Ans: Compounds which give maximal response after receptor

occupation and activation.


-Example: Oxycodone




Partial Agonists:

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Ans: Compounds which activate the receptor but not at the maximal

response.


-Example Buprenorphine (Suboxone) or Buspirone




Antagonist:


Ans: Blocks the action of an agonist.


-Example: Neuroleptics, Naloxone




Inverse Agonist:


Ans: Binds to receptor and has the opposite action of an agonist and

below baselinesignal transduction




Pharmacokinetics


Ans: How the body effects the drug


-Absorption, distribution, metabolism and elimination (ADME)


-Metabolizing the drug via CYP450 through the gut & liver