NAPSRX Chapter 10
The aim of preclinical pharmacological studies is to obtain data on the safety and effectiveness of the
lead compound. T or F - Answer-True
Toxicity information in preclinical studies helps provides confidence about a drug's safety. T or F -
Answer-True
Pharmacological studies using animals are regulated under Good Laboratory Practice. T or F - Answer-
True
Why do drugs administered to patients only contain APIs (active Pharmaceutical ingredients)? - Answer-
They don't
What affects a drug's ability to permeate membranes? - Answer--the drug's chemical composition
-the drug's polarity
-the drug's size
Through which barriers can lipid-soluble drugs usually pass? - Answer-cell membranes
Which of the following routes of administration do not completely bypass the liver?
-intravenous administration
The aim of preclinical pharmacological studies is to obtain data on the safety and effectiveness of the
lead compound. T or F - Answer-True
Toxicity information in preclinical studies helps provides confidence about a drug's safety. T or F -
Answer-True
Pharmacological studies using animals are regulated under Good Laboratory Practice. T or F - Answer-
True
Why do drugs administered to patients only contain APIs (active Pharmaceutical ingredients)? - Answer-
They don't
What affects a drug's ability to permeate membranes? - Answer--the drug's chemical composition
-the drug's polarity
-the drug's size
Through which barriers can lipid-soluble drugs usually pass? - Answer-cell membranes
Which of the following routes of administration do not completely bypass the liver?
-intravenous administration