NU 665C REGIS COLLEGE EXAM 2025/2026 QUESTIONS
WITH ANSWERS GRADED A+
✔✔What are FDA-approved medications for opioid use disorder (OUD)? -
✔✔Methadone - Full opioid agonist; prevents withdrawal and cravings
Buprenorphine - Partial opioid agonist; reduces cravings with lower overdose risk
Naltrexone - Opioid antagonist; prevents relapse by blocking opioid effects
✔✔Which MOUD is best for patients with severe dependence or pregnancy? -
✔✔Methadone
✔✔What are the risks of buprenorphine induction? - ✔✔Precipitated withdrawal if
started too soon after opioid use.
✔✔What are the main screening tools for substance use disorders? - ✔✔AUDIT
(Alcohol Use Disorders Identification Test) - Identifies hazardous drinking
CAGE Questionnaire - 4-question screening for alcohol dependence
SBIRT (Screening, Brief Intervention, and Referral to Treatment) - Framework for early
intervention
✔✔What questions make up the CAGE questionnaire? - ✔✔Have you ever felt you
should Cut down on drinking?
Have people Annoyed you by criticizing your drinking?
Have you ever felt Guilty about your drinking?
Have you ever needed a drink first thing in the morning (Eye-opener) to calm nerves?
✔✔What is a positive CAGE score? - ✔✔2 or more "yes" answers suggest possible
alcohol dependence.
✔✔What is the relationship between substance use and psychiatric disorders? -
✔✔High rates of co-occurring depression, anxiety, PTSD, and schizophrenia
Substance use can exacerbate mental illness symptoms
Self-medication hypothesis: People use substances to relieve psychiatric symptoms
✔✔What are risk factors for co-occurring disorders, substance use and psychiatric
disorders? - ✔✔Early trauma and ACEs (Adverse Childhood Experiences)
Family history of substance use or mental illness
Lack of social support
✔✔What are treatment considerations for first-episode psychosis (FEP) and substance
use? - ✔✔Avoid high-dose antipsychotics
Consider clozapine for treatment-resistant psychosis with SUD
Integrated treatment for both disorders improves outcomes
, ✔✔What is unique about substance use in adolescents? - ✔✔Higher risk of long-term
addiction due to neurodevelopmental changes
Common substances: Alcohol, cannabis, nicotine, stimulants
Screen using CRAFFT questionnaire
✔✔What are considerations for substance use disorders in LGBTQ populations? -
✔✔Higher rates due to stigma, discrimination, minority stress
Increased risk of opioid misuse and alcohol use disorders
Need for affirmative and inclusive care
✔✔What medications are FDA-approved for alcohol use disorder (AUD)? -
✔✔Naltrexone - Reduces cravings and blocks rewarding effects of alcohol
Acamprosate - Restores neurotransmitter balance to reduce cravings
Disulfiram - Causes aversive reaction when alcohol is consumed
✔✔What laboratory findings are associated with chronic alcohol use? - ✔✔Elevated
AST/ALT (AST > ALT) - Liver damage
Macrocytosis (MCV > 100 fL) - Due to vitamin B12/folate deficiency
Thiamine deficiency - Risk of Wernicke-Korsakoff syndrome
✔✔What lab abnormalities are common in opioid use disorder? - ✔✔Elevated CK
(creatine kinase) - Rhabdomyolysis in overdose
Hypoxia - Due to respiratory depression
Low testosterone levels - Due to chronic opioid use
✔✔Opioid Risk Tool (ORT) - Assesses risk for opioid misuse in pain patients. - ✔✔A
score of <3 indicates low risk
A moderate risk score is 4 to 7
High risk scores are ≥8
The main drawback of the ORT is its susceptibility to deception.
✔✔COWS (Clinical Opiate Withdrawal Scale) - Evaluates withdrawal severity. - ✔✔5-
12: Mild withdrawal
13-24: Moderate withdrawal
25-36: Moderately severe withdrawal
More than 36: Severe withdrawal
✔✔SOAPP-R (Screener and Opioid Assessment for Patients with Pain-Revised) -
✔✔Identifies
patients at risk for opioid misuse.
> 18 considered high risk for opioid misuse
✔✔DAST (Drug Abuse Screening Test) - Screens for general substance abuse, opioids
- ✔✔0: none
WITH ANSWERS GRADED A+
✔✔What are FDA-approved medications for opioid use disorder (OUD)? -
✔✔Methadone - Full opioid agonist; prevents withdrawal and cravings
Buprenorphine - Partial opioid agonist; reduces cravings with lower overdose risk
Naltrexone - Opioid antagonist; prevents relapse by blocking opioid effects
✔✔Which MOUD is best for patients with severe dependence or pregnancy? -
✔✔Methadone
✔✔What are the risks of buprenorphine induction? - ✔✔Precipitated withdrawal if
started too soon after opioid use.
✔✔What are the main screening tools for substance use disorders? - ✔✔AUDIT
(Alcohol Use Disorders Identification Test) - Identifies hazardous drinking
CAGE Questionnaire - 4-question screening for alcohol dependence
SBIRT (Screening, Brief Intervention, and Referral to Treatment) - Framework for early
intervention
✔✔What questions make up the CAGE questionnaire? - ✔✔Have you ever felt you
should Cut down on drinking?
Have people Annoyed you by criticizing your drinking?
Have you ever felt Guilty about your drinking?
Have you ever needed a drink first thing in the morning (Eye-opener) to calm nerves?
✔✔What is a positive CAGE score? - ✔✔2 or more "yes" answers suggest possible
alcohol dependence.
✔✔What is the relationship between substance use and psychiatric disorders? -
✔✔High rates of co-occurring depression, anxiety, PTSD, and schizophrenia
Substance use can exacerbate mental illness symptoms
Self-medication hypothesis: People use substances to relieve psychiatric symptoms
✔✔What are risk factors for co-occurring disorders, substance use and psychiatric
disorders? - ✔✔Early trauma and ACEs (Adverse Childhood Experiences)
Family history of substance use or mental illness
Lack of social support
✔✔What are treatment considerations for first-episode psychosis (FEP) and substance
use? - ✔✔Avoid high-dose antipsychotics
Consider clozapine for treatment-resistant psychosis with SUD
Integrated treatment for both disorders improves outcomes
, ✔✔What is unique about substance use in adolescents? - ✔✔Higher risk of long-term
addiction due to neurodevelopmental changes
Common substances: Alcohol, cannabis, nicotine, stimulants
Screen using CRAFFT questionnaire
✔✔What are considerations for substance use disorders in LGBTQ populations? -
✔✔Higher rates due to stigma, discrimination, minority stress
Increased risk of opioid misuse and alcohol use disorders
Need for affirmative and inclusive care
✔✔What medications are FDA-approved for alcohol use disorder (AUD)? -
✔✔Naltrexone - Reduces cravings and blocks rewarding effects of alcohol
Acamprosate - Restores neurotransmitter balance to reduce cravings
Disulfiram - Causes aversive reaction when alcohol is consumed
✔✔What laboratory findings are associated with chronic alcohol use? - ✔✔Elevated
AST/ALT (AST > ALT) - Liver damage
Macrocytosis (MCV > 100 fL) - Due to vitamin B12/folate deficiency
Thiamine deficiency - Risk of Wernicke-Korsakoff syndrome
✔✔What lab abnormalities are common in opioid use disorder? - ✔✔Elevated CK
(creatine kinase) - Rhabdomyolysis in overdose
Hypoxia - Due to respiratory depression
Low testosterone levels - Due to chronic opioid use
✔✔Opioid Risk Tool (ORT) - Assesses risk for opioid misuse in pain patients. - ✔✔A
score of <3 indicates low risk
A moderate risk score is 4 to 7
High risk scores are ≥8
The main drawback of the ORT is its susceptibility to deception.
✔✔COWS (Clinical Opiate Withdrawal Scale) - Evaluates withdrawal severity. - ✔✔5-
12: Mild withdrawal
13-24: Moderate withdrawal
25-36: Moderately severe withdrawal
More than 36: Severe withdrawal
✔✔SOAPP-R (Screener and Opioid Assessment for Patients with Pain-Revised) -
✔✔Identifies
patients at risk for opioid misuse.
> 18 considered high risk for opioid misuse
✔✔DAST (Drug Abuse Screening Test) - Screens for general substance abuse, opioids
- ✔✔0: none
