Basic & Clinical Pharmacology, Katzung;
Chapter 1-4
1. 4 types of agonist receptors -- Correct Answer --Ion channels, G-protein coupled, enzyme
coupled, intracellular
2. Absorption -- Correct Answer --the movement of a drug from the site of administration to
bloodstream; intake of a drug into the system
3. Active transport -- Correct Answer --carriers grab the drug and use energy to move it
across the membrane
4. Administration -- Correct Answer --ways of drug delivery
5. Agonist -- Correct Answer --drug binds to a receptor and activates the receptor
6. Antacids -- Correct Answer --affects pH (gastric)
7. Antagonist -- Correct Answer --drug binds to receptor and does not activate
8. Bioavailability -- Correct Answer --the portion of the drug that reaches the bloodstream
9. Biotransformation -- Correct Answer --the chemical changes that occur to a drug
following administration
10. Competitive -- Correct Answer --the drug comes onto and off of the receptor, so if
another agent that can bind to the receptor is present, they will compete
11. Continuous dose response curve -- Correct Answer --A graph of increasing response to
increasing drug concentration or dose
12. Continuous infusion -- Correct Answer --Introduction of a substance such as IV fluids or
interstitial fluids over a period of time without interruption
, 13. Distribution -- Correct Answer --the transfer of a drug from one location to another
within the body; where the drug goes following absorption
14. Dosing frequency -- Correct Answer --the time interval between doses when a drug is
given intermittently
15. Drug -- Correct Answer --any chemical agent that when taken into a living organism may
modify one or more of its functions
16. Drug regimen simplification -- Correct Answer --using same dosing schedule; pill
organizers; blister packs
17. Drug-receptor interaction -- Correct Answer --leads to either increase or decrease in a
biochemical process in the cell
18. EC50 -- Correct Answer --half maximum effective concentration; concentration of a drug
at which 50% of its maximum response is observed
19. ED50 -- Correct Answer --median effective dose; therapeutic effect; the dose required to
achieve 50% of desired response in 50% of the population
20. Effect -- Correct Answer --the change in the organism caused by the chemical
21. Efficacy -- Correct Answer --the maximum response of a drug
22. Elimination -- Correct Answer --the removal of materials from the body; removal of a
drug
23. Factors influencing distribution -- Correct Answer --tissue permeability, blood flow,
binding to proteins
24. Factors influencing drug response and kinetics -- Correct Answer --Genetics, disease,
age, gender, other drugs, diet
Chapter 1-4
1. 4 types of agonist receptors -- Correct Answer --Ion channels, G-protein coupled, enzyme
coupled, intracellular
2. Absorption -- Correct Answer --the movement of a drug from the site of administration to
bloodstream; intake of a drug into the system
3. Active transport -- Correct Answer --carriers grab the drug and use energy to move it
across the membrane
4. Administration -- Correct Answer --ways of drug delivery
5. Agonist -- Correct Answer --drug binds to a receptor and activates the receptor
6. Antacids -- Correct Answer --affects pH (gastric)
7. Antagonist -- Correct Answer --drug binds to receptor and does not activate
8. Bioavailability -- Correct Answer --the portion of the drug that reaches the bloodstream
9. Biotransformation -- Correct Answer --the chemical changes that occur to a drug
following administration
10. Competitive -- Correct Answer --the drug comes onto and off of the receptor, so if
another agent that can bind to the receptor is present, they will compete
11. Continuous dose response curve -- Correct Answer --A graph of increasing response to
increasing drug concentration or dose
12. Continuous infusion -- Correct Answer --Introduction of a substance such as IV fluids or
interstitial fluids over a period of time without interruption
, 13. Distribution -- Correct Answer --the transfer of a drug from one location to another
within the body; where the drug goes following absorption
14. Dosing frequency -- Correct Answer --the time interval between doses when a drug is
given intermittently
15. Drug -- Correct Answer --any chemical agent that when taken into a living organism may
modify one or more of its functions
16. Drug regimen simplification -- Correct Answer --using same dosing schedule; pill
organizers; blister packs
17. Drug-receptor interaction -- Correct Answer --leads to either increase or decrease in a
biochemical process in the cell
18. EC50 -- Correct Answer --half maximum effective concentration; concentration of a drug
at which 50% of its maximum response is observed
19. ED50 -- Correct Answer --median effective dose; therapeutic effect; the dose required to
achieve 50% of desired response in 50% of the population
20. Effect -- Correct Answer --the change in the organism caused by the chemical
21. Efficacy -- Correct Answer --the maximum response of a drug
22. Elimination -- Correct Answer --the removal of materials from the body; removal of a
drug
23. Factors influencing distribution -- Correct Answer --tissue permeability, blood flow,
binding to proteins
24. Factors influencing drug response and kinetics -- Correct Answer --Genetics, disease,
age, gender, other drugs, diet
