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Quiz: A patient has been diagnosed with acute lymphocytic leukemia (ALL) and asks the
healthcare professional to describe it. What description by the professional is most
accurate?
a. ALL is a progressive neoplasm defined by the presence of greater than 30% lymphoblasts
in the bone marrow or blood
b. In ALL, immature blasts cells replace normal myelocytic cells, megakaryocytes, and
erythrocytes
c. B cells fail to mature into plasma cells that synthesize immunoglobulins
d. The translocation of genetic material from genes 9 and 22 create an abnormal, fused gene
identified as BCR-ABL
Ans: a. ALL is a progressive neoplasm defined by the presence of greater than 30%
lymphoblasts in the bone marrow or blood
Quiz: Which of the following describes CML (Chronic Myelogenous Leukemia)? (Select all
that apply.)
a. Progresses rapidly
b. Splenomegaly is a common finding in the accelerated phase
c. Reciprocal translocation between chromosomes 9 and 22 (Philadelphia Chromosome) is
present in 95% of cases
d. Can lead to pancytopenia
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, Ans: b. Splenomegaly is a common finding in the accelerated phase
c. Reciprocal translocation between chromosomes 9 and 22 (Philadelphia Chromosome) is
present in 95% of cases
d. Can lead to pancytopenia
Quiz: Folate and vitamin B12 deficiencies alter the synthesis of which of the
following, which results in apoptotic destruction of maturing erythrocytes?
a. Complement receptors on the cell surface
b. Antigens on the cell surface
c. DNA
d. Mitochondria
Ans: c. DNA
Quiz: Hemophilia, a genetic bleeding disorder, is due to:
a. Deficiencies of coagulation factor VIII, factor IX or factor XI
b. Deficiency of tissue factor
c. Deficiency in Vitamin K
d. Deficiency of coagulation factor X
Ans: a. Deficiencies of coagulation factor VIII, factor IX or factor XI
Quiz: The characteristic sickling shape of the red blood cell in sickle cell anemia is
due to:
a. An autosomal recessive disease that results in the replacement of a
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in the number given.