BCH Final Exam Questions And Answers
______________rinrcomplexr1rofroxphosralllwsrforrH+rtormoveracrossrthermembraner-
rCORRECTrrANSWER-
conformationalrchangesrcausedrbyrthermovingrofrelectronsrthroughrthercomplex
______________rmetabolicrpathwayrisrmostrfrequentlyrusedrforrbuildingrbiopolymersrsuchr
asrlipids,rnucleicracids,rproteinsrandrpolysaccharidesr-rCORRECTrrANSWER-
spiralrpathway
_________________risrboundrtortherinnerrmitochondriarmembranerandrcontributesritsrelec
tronsrvierQH2rtorthercomplexr2rinrtheroxidativerphosphorylationrpathwayrdirectlyr-
rCORRECTrrANSWER-succinaterdehydrogenase
__________________risrequivalentrtorcomplexr2rinroxphosr-rCORRECTrrANSWER-
succinaterdehydrogenase
__________________rmetabolismrisroftenrdefinedrasrthoserreactionsrinvolvingrlowrmolecu
larrweightrbiomoleculesr-rCORRECTrrANSWER-intermediary
__________________rphosphorylatesrpyruvaterdehydrogenaserwhiler_______________
__rdephosphorylatesritr(thisrisrregulationrbyr______________________)r-
rCORRECTrrANSWER-PDHrkinaser
PDHrphosphataser
covalentrmodification
1rNADHr-->r____rATPr-rCORRECTrrANSWER-2.5
1rQH2r--->r____rATPr-rCORRECTrrANSWER-1.5
1,3-
Bisphosphoglyceraterhasrarhighrphosphorylrgroupr____________randrresultsrinrtherproduc
tionrofr________________ritrhasrardeltarGrofr-rCORRECTrrANSWER-transferrpotential
firstrATProfrglycolysisr
-49.4rkJ/mol
arsignificantramountrofrgenomerisrcommittedrtor______________
-r____%rofr_____rinrercoli
,-r_____%rofr_____rinryeast
-______%rofr______rinrhumansr-rCORRECTrrANSWER-metabolismr
21rofr900
21rofr1200
23rofr5000
AcetylrCoArcontainsrarhighrenergyr___________rbondr-rCORRECTrrANSWER-thioester
aconitaserconvertsrar___________ralcoholrtorar__________ralcoholr
explainrwhyr-rCORRECTrrANSWER-tertiaryrtorsecondary
tertiaryrarerchemicallyrveryrstablerandrunreactiverwhilersecondaryrarermorerreactiverwhichri
srnecessaryrforrthernextrreactionrtorberablertoroccur
actualrgibbsrfreerenergyrchange,rnotr________________________-
rdeterminesrtherdirectionrofrmetabolicrreactionsr-rCORRECTrrANSWER-
standardrfreerenergyrchange
ADPrtorAMPrdeltarGr=r-rCORRECTrrANSWER--13.8rkJ/mol
ADPrtorAMPrdeltarG=r-rCORRECTrrANSWER--45.6rkJ/mol
allrthreerofrtherregulatedrenzymesrinrglycolysisrarer__________r-rCORRECTrrANSWER-
kinases
alpharketoglutaratercanrleadrtortherformationrofr______________randr_______________-r-
rCORRECTrrANSWER-glutamater
otherraminoracids,rpurines
Alpharketoglutaraterisrar______________________-r-rCORRECTrrANSWER-
5rcarbonrdicarboxylicracid
alpharketogluteraterdehydrogenasercatalyzesr_____________________rreactionrthatruse
sranr_____________randr_______________rtorproducerarhighrenergyr__________rbondra
ndr__________randr______________r-rCORRECTrrANSWER-oxidation-
reductionrreactionr
alpharketoracidr
coenzymerA
thioester
CO2randrNADH
anrenergeticallyrunfavorablermetabolicrreactionrcanrberdrivenrbyrcouplingr_____________
_______rwithrtherreactionr-rCORRECTrrANSWER-ATPrhydrolysis
anabolicrreactionsrarertypicallyr_______________rreactionsr-rCORRECTrrANSWER-
reduction
, atrstandardrconditionsrtherthermodynamicsrofrarreactionratr_________________r-
rCORRECTrrANSWER-equilibrium
ATPrisrarproductrofr____________rreactionsrandranrenergyrsourcerforr_____________rrea
ctionsr-rCORRECTrrANSWER-catabolicr
anabolic
ATPrisrtheruniversalrcurrencyrofr____________________rinrallrbiologicalrsystemsr-
rCORRECTrrANSWER-freerenergy
ATPrsynthaserisrcomposedrofrbetweenr_____rtor_____rsubunitsrthatrcanrberdividedrintor___
__randr______rcomponentsr-rCORRECTrrANSWER-22randr26
Fnot
F1
ATPrtorADPrdeltarG=r-rCORRECTrrANSWER--32.2rkJ/mol
bothrNADHrandrQH2rcontainr___________________randrwillrberusedrtorproducerenergyras
rATPrduringr__________________r-rCORRECTrrANSWER-reducingrpowerr
oxidativerphosphorylation
catabolicrreactionsrarertypicallyr______________rreactionsr-rCORRECTrrANSWER-
oxidation
citratercanrleadrtortherformationrofr____________r-rCORRECTrrANSWER-
fattyracidsrandrsterols
Citratersynthaserisranrexamplerofrinducedrfitrenzymerregulation.rexplainr-
rCORRECTrrANSWER--
rbindingrofroxaloacetaterinducesrclosurerofrthersmallrdomainrwhichrcreatesrarbindingrsiterforr
acetylrCoA
citratersynthase,risocitraterdehydrogenase,randralpharketogluteraterdehydrogenaserarerallr
controlledrbyr_____________rregulationr-rCORRECTrrANSWER-allosteric
coenzymerQrmovesrfreelyrinrther_______________b/critrisr______________r-
rCORRECTrrANSWER-lipidrbilayerr
lipidrsoluble
coenzymesrcanrberdividedrintor________________randr__________r-
rCORRECTrrANSWER-cosubstratesr(looselyrbound)r
prostheticrgroupsr(tightleyrbound)
Cofactorsrcanrberdividedrintor________________randr_______________r-
rCORRECTrrANSWER-essentialrionsrandrcoenzymes
______________rinrcomplexr1rofroxphosralllwsrforrH+rtormoveracrossrthermembraner-
rCORRECTrrANSWER-
conformationalrchangesrcausedrbyrthermovingrofrelectronsrthroughrthercomplex
______________rmetabolicrpathwayrisrmostrfrequentlyrusedrforrbuildingrbiopolymersrsuchr
asrlipids,rnucleicracids,rproteinsrandrpolysaccharidesr-rCORRECTrrANSWER-
spiralrpathway
_________________risrboundrtortherinnerrmitochondriarmembranerandrcontributesritsrelec
tronsrvierQH2rtorthercomplexr2rinrtheroxidativerphosphorylationrpathwayrdirectlyr-
rCORRECTrrANSWER-succinaterdehydrogenase
__________________risrequivalentrtorcomplexr2rinroxphosr-rCORRECTrrANSWER-
succinaterdehydrogenase
__________________rmetabolismrisroftenrdefinedrasrthoserreactionsrinvolvingrlowrmolecu
larrweightrbiomoleculesr-rCORRECTrrANSWER-intermediary
__________________rphosphorylatesrpyruvaterdehydrogenaserwhiler_______________
__rdephosphorylatesritr(thisrisrregulationrbyr______________________)r-
rCORRECTrrANSWER-PDHrkinaser
PDHrphosphataser
covalentrmodification
1rNADHr-->r____rATPr-rCORRECTrrANSWER-2.5
1rQH2r--->r____rATPr-rCORRECTrrANSWER-1.5
1,3-
Bisphosphoglyceraterhasrarhighrphosphorylrgroupr____________randrresultsrinrtherproduc
tionrofr________________ritrhasrardeltarGrofr-rCORRECTrrANSWER-transferrpotential
firstrATProfrglycolysisr
-49.4rkJ/mol
arsignificantramountrofrgenomerisrcommittedrtor______________
-r____%rofr_____rinrercoli
,-r_____%rofr_____rinryeast
-______%rofr______rinrhumansr-rCORRECTrrANSWER-metabolismr
21rofr900
21rofr1200
23rofr5000
AcetylrCoArcontainsrarhighrenergyr___________rbondr-rCORRECTrrANSWER-thioester
aconitaserconvertsrar___________ralcoholrtorar__________ralcoholr
explainrwhyr-rCORRECTrrANSWER-tertiaryrtorsecondary
tertiaryrarerchemicallyrveryrstablerandrunreactiverwhilersecondaryrarermorerreactiverwhichri
srnecessaryrforrthernextrreactionrtorberablertoroccur
actualrgibbsrfreerenergyrchange,rnotr________________________-
rdeterminesrtherdirectionrofrmetabolicrreactionsr-rCORRECTrrANSWER-
standardrfreerenergyrchange
ADPrtorAMPrdeltarGr=r-rCORRECTrrANSWER--13.8rkJ/mol
ADPrtorAMPrdeltarG=r-rCORRECTrrANSWER--45.6rkJ/mol
allrthreerofrtherregulatedrenzymesrinrglycolysisrarer__________r-rCORRECTrrANSWER-
kinases
alpharketoglutaratercanrleadrtortherformationrofr______________randr_______________-r-
rCORRECTrrANSWER-glutamater
otherraminoracids,rpurines
Alpharketoglutaraterisrar______________________-r-rCORRECTrrANSWER-
5rcarbonrdicarboxylicracid
alpharketogluteraterdehydrogenasercatalyzesr_____________________rreactionrthatruse
sranr_____________randr_______________rtorproducerarhighrenergyr__________rbondra
ndr__________randr______________r-rCORRECTrrANSWER-oxidation-
reductionrreactionr
alpharketoracidr
coenzymerA
thioester
CO2randrNADH
anrenergeticallyrunfavorablermetabolicrreactionrcanrberdrivenrbyrcouplingr_____________
_______rwithrtherreactionr-rCORRECTrrANSWER-ATPrhydrolysis
anabolicrreactionsrarertypicallyr_______________rreactionsr-rCORRECTrrANSWER-
reduction
, atrstandardrconditionsrtherthermodynamicsrofrarreactionratr_________________r-
rCORRECTrrANSWER-equilibrium
ATPrisrarproductrofr____________rreactionsrandranrenergyrsourcerforr_____________rrea
ctionsr-rCORRECTrrANSWER-catabolicr
anabolic
ATPrisrtheruniversalrcurrencyrofr____________________rinrallrbiologicalrsystemsr-
rCORRECTrrANSWER-freerenergy
ATPrsynthaserisrcomposedrofrbetweenr_____rtor_____rsubunitsrthatrcanrberdividedrintor___
__randr______rcomponentsr-rCORRECTrrANSWER-22randr26
Fnot
F1
ATPrtorADPrdeltarG=r-rCORRECTrrANSWER--32.2rkJ/mol
bothrNADHrandrQH2rcontainr___________________randrwillrberusedrtorproducerenergyras
rATPrduringr__________________r-rCORRECTrrANSWER-reducingrpowerr
oxidativerphosphorylation
catabolicrreactionsrarertypicallyr______________rreactionsr-rCORRECTrrANSWER-
oxidation
citratercanrleadrtortherformationrofr____________r-rCORRECTrrANSWER-
fattyracidsrandrsterols
Citratersynthaserisranrexamplerofrinducedrfitrenzymerregulation.rexplainr-
rCORRECTrrANSWER--
rbindingrofroxaloacetaterinducesrclosurerofrthersmallrdomainrwhichrcreatesrarbindingrsiterforr
acetylrCoA
citratersynthase,risocitraterdehydrogenase,randralpharketogluteraterdehydrogenaserarerallr
controlledrbyr_____________rregulationr-rCORRECTrrANSWER-allosteric
coenzymerQrmovesrfreelyrinrther_______________b/critrisr______________r-
rCORRECTrrANSWER-lipidrbilayerr
lipidrsoluble
coenzymesrcanrberdividedrintor________________randr__________r-
rCORRECTrrANSWER-cosubstratesr(looselyrbound)r
prostheticrgroupsr(tightleyrbound)
Cofactorsrcanrberdividedrintor________________randr_______________r-
rCORRECTrrANSWER-essentialrionsrandrcoenzymes