OPT 210 Diagnostic Ophthalmic Pharmaceuticals New Update!!
What is a single dose unit ophthalmic drop?
-vials (0.4 to 0.8 mL with no preservatives (so no ingredient to stop microbial growth)
-once opened, should be discarded right away
What is a multiple dose preserved unit ophthalmic drop?
drop intended for repeated use, containing a preservative
What is the function of a preservative in eye drops?
chemical with antimicrobial action that rapidly limits growth or kills microorganisms
(also increases shelf life)
What are examples of common preservatives?
-benzalkonium chloride (BAC or BAK)
-polidronium
-polyhexylmethylbiguanide
-chlorhexidine
-thimerosal
What are multiple dose preservative free unit ophthalmic drops?
,-one way valve that dispenses only one sterile drop
-tip mechanism closes after each use
-filter protects solution from airborne micro organisms
What are examples of MDPF products?
-clear eyes pure relief
-restasis
-oasis tears
-refresh relieva
-hydrasense drops
What are ophthalmic solutions?
aqueous solution containing saline, buffering salts, and polymers
What do buffering salts do?
maintains pH from 5.0 to 8.0 (normal tear pH is around 7.4 and comfort zone is 6.6 to
7.8)
What are benefits of ophthalmic solutions?
-more comfortable upon instillation
-longer shelf life (about two years)
, What do polymers do?
modify the viscosity of the solution
What is beneficial about a higher viscosity?
the solution will last longer on the corneal surface
What are some commonly used polymers?
-cellulose derivatives
-polysaccharides
-etc (do not need to memorize just be aware)
What is an ophthalmic suspension?
heterogenous compound with milky appearance (contains solid particles dispersed in
solute to increase contact time)
What happens when sediments occur with ophthalmic suspensions?
must be shaken to re disperse particles into the liquid (particles must be small enough
to not irritate surface of the eye <10 microns)
What is an ophthalmic gel?
-highly viscous solution with saline aqueous base and muco adhesive polymer
-bioadhesion attaches drug to biological tissue
What is a single dose unit ophthalmic drop?
-vials (0.4 to 0.8 mL with no preservatives (so no ingredient to stop microbial growth)
-once opened, should be discarded right away
What is a multiple dose preserved unit ophthalmic drop?
drop intended for repeated use, containing a preservative
What is the function of a preservative in eye drops?
chemical with antimicrobial action that rapidly limits growth or kills microorganisms
(also increases shelf life)
What are examples of common preservatives?
-benzalkonium chloride (BAC or BAK)
-polidronium
-polyhexylmethylbiguanide
-chlorhexidine
-thimerosal
What are multiple dose preservative free unit ophthalmic drops?
,-one way valve that dispenses only one sterile drop
-tip mechanism closes after each use
-filter protects solution from airborne micro organisms
What are examples of MDPF products?
-clear eyes pure relief
-restasis
-oasis tears
-refresh relieva
-hydrasense drops
What are ophthalmic solutions?
aqueous solution containing saline, buffering salts, and polymers
What do buffering salts do?
maintains pH from 5.0 to 8.0 (normal tear pH is around 7.4 and comfort zone is 6.6 to
7.8)
What are benefits of ophthalmic solutions?
-more comfortable upon instillation
-longer shelf life (about two years)
, What do polymers do?
modify the viscosity of the solution
What is beneficial about a higher viscosity?
the solution will last longer on the corneal surface
What are some commonly used polymers?
-cellulose derivatives
-polysaccharides
-etc (do not need to memorize just be aware)
What is an ophthalmic suspension?
heterogenous compound with milky appearance (contains solid particles dispersed in
solute to increase contact time)
What happens when sediments occur with ophthalmic suspensions?
must be shaken to re disperse particles into the liquid (particles must be small enough
to not irritate surface of the eye <10 microns)
What is an ophthalmic gel?
-highly viscous solution with saline aqueous base and muco adhesive polymer
-bioadhesion attaches drug to biological tissue
