BIOD331
Neoplasia
Final Test Review (Qns & Ans)
2025
1. Which of the following is a hallmark of malignant neoplasms?
- A. Limited growth
- B. Well-differentiated cells
- C. Invasion of surrounding tissues
- D. Encapsulation
- ANS: C. Invasion of surrounding tissues
- Rationale: Malignant neoplasms are characterized by their
ability to invade surrounding tissues and metastasize to distant
sites.
©2025
,2. What is the primary function of tumor suppressor genes?
- A. Promote cell division
- B. Repair DNA damage
- C. Inhibit cell growth
- D. Induce apoptosis
- ANS: C. Inhibit cell growth
- Rationale: Tumor suppressor genes regulate cell growth and
division, preventing uncontrolled cell proliferation.
3. Which type of cancer is associated with the presence of the
Philadelphia chromosome?
- A. Breast cancer
- B. Chronic myeloid leukemia
- C. Lung cancer
- D. Colorectal cancer
- ANS: B. Chronic myeloid leukemia
- Rationale: The Philadelphia chromosome is a genetic
abnormality associated with chronic myeloid leukemia (CML).
4. Which of the following is a common oncogene involved in
cancer development?
©2025
, - A. BRCA1
- B. TP53
- C. HER2
- D. RB1
- ANS: C. HER2
- Rationale: HER2 is an oncogene that, when overexpressed,
can lead to the development of certain types of cancer, such as
breast cancer.
5. What is the primary mechanism of action for chemotherapy
drugs?
- A. Enhancing immune response
- B. Inhibiting angiogenesis
- C. Inducing DNA damage
- D. Blocking hormone receptors
- ANS: C. Inducing DNA damage
- Rationale: Chemotherapy drugs primarily work by inducing
DNA damage in rapidly dividing cancer cells, leading to cell
death.
Fill-in-the-Blank
©2025
, 6. ______ is the process by which cancer cells spread from the
primary tumor to distant sites in the body.
- ANS: Metastasis
- Rationale: Metastasis is the spread of cancer cells from the
primary tumor to other parts of the body, forming secondary
tumors.
7. The ______ ______ is a genetic mutation commonly found in
colorectal cancer, leading to uncontrolled cell growth.
- ANS: APC gene
- Rationale: Mutations in the APC gene are commonly
associated with colorectal cancer and contribute to uncontrolled
cell proliferation.
8. ______ ______ is a type of cancer that originates in the
epithelial cells lining the organs and tissues.
- ANS: Carcinoma
- Rationale: Carcinomas are cancers that arise from epithelial
cells, which line the surfaces of organs and tissues.
9. The ______ ______ is a grading system used to assess the
aggressiveness of prostate cancer based on histological
appearance.
- ANS: Gleason Score
©2025
Neoplasia
Final Test Review (Qns & Ans)
2025
1. Which of the following is a hallmark of malignant neoplasms?
- A. Limited growth
- B. Well-differentiated cells
- C. Invasion of surrounding tissues
- D. Encapsulation
- ANS: C. Invasion of surrounding tissues
- Rationale: Malignant neoplasms are characterized by their
ability to invade surrounding tissues and metastasize to distant
sites.
©2025
,2. What is the primary function of tumor suppressor genes?
- A. Promote cell division
- B. Repair DNA damage
- C. Inhibit cell growth
- D. Induce apoptosis
- ANS: C. Inhibit cell growth
- Rationale: Tumor suppressor genes regulate cell growth and
division, preventing uncontrolled cell proliferation.
3. Which type of cancer is associated with the presence of the
Philadelphia chromosome?
- A. Breast cancer
- B. Chronic myeloid leukemia
- C. Lung cancer
- D. Colorectal cancer
- ANS: B. Chronic myeloid leukemia
- Rationale: The Philadelphia chromosome is a genetic
abnormality associated with chronic myeloid leukemia (CML).
4. Which of the following is a common oncogene involved in
cancer development?
©2025
, - A. BRCA1
- B. TP53
- C. HER2
- D. RB1
- ANS: C. HER2
- Rationale: HER2 is an oncogene that, when overexpressed,
can lead to the development of certain types of cancer, such as
breast cancer.
5. What is the primary mechanism of action for chemotherapy
drugs?
- A. Enhancing immune response
- B. Inhibiting angiogenesis
- C. Inducing DNA damage
- D. Blocking hormone receptors
- ANS: C. Inducing DNA damage
- Rationale: Chemotherapy drugs primarily work by inducing
DNA damage in rapidly dividing cancer cells, leading to cell
death.
Fill-in-the-Blank
©2025
, 6. ______ is the process by which cancer cells spread from the
primary tumor to distant sites in the body.
- ANS: Metastasis
- Rationale: Metastasis is the spread of cancer cells from the
primary tumor to other parts of the body, forming secondary
tumors.
7. The ______ ______ is a genetic mutation commonly found in
colorectal cancer, leading to uncontrolled cell growth.
- ANS: APC gene
- Rationale: Mutations in the APC gene are commonly
associated with colorectal cancer and contribute to uncontrolled
cell proliferation.
8. ______ ______ is a type of cancer that originates in the
epithelial cells lining the organs and tissues.
- ANS: Carcinoma
- Rationale: Carcinomas are cancers that arise from epithelial
cells, which line the surfaces of organs and tissues.
9. The ______ ______ is a grading system used to assess the
aggressiveness of prostate cancer based on histological
appearance.
- ANS: Gleason Score
©2025
