MRCP OFFICIAL SAMPLE
QUESTIONS & ANSWERS SOLVED
100% CORRECT!!
1 of 31
Term
A 30-year-old man had moved recently to the UK. He informed his
doctor that he had maturity-onset diabetes of the young.
What feature, if present, most strongly suggests that this is the
correct diagnosis?
A: a BMI of 30.0 kg/m2 (18.0-25.0)
B: a poor response to glipizide therapy
,C: a strong family history of diabetes mellitus
D: recurrent episodes of diabetic ketoacidosis
E: X-linked recessive inheritance
Give this one a try later!
B C
D E
Don't know?
2 of 31
Term
A 17-year-old boy presented with breathlessness and night sweats.
Investigations confirmed a diagnosis of Burkitt lymphoma.
What is the most likely underlying abnormality of gene expression?
A: expression of BCR-ABL
B: loss of p53
C: overexpression of BCL-2
D: overexpression of c-myc
,E: overexpression of JAK2
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B C
D E
Don't know?
3 of 31
Term
A 45-year-old woman presented with right flank pain. She had a 4-
year history of hypertension and progressive cognitive impairment.
On examination, she had livedo reticularis and tenderness in the
right flank. Her BP was 185/105 mmHg. Urinalysis showed blood 3+,
protein 1+.
Hb 129 g/L (115-165) WCC 8.7 × 109/L (4.0-11.0) PlTs 83 × 109/L (150-
400)
serum creatinine 106 µmol/L (60-110)
What antibody test is most likely to be positive?
A: anticardiolipin
, B: anticentromere
C: anti-glomerular basement membrane
D: antimitochondrial
E: anti-neutrophil cytoplasmic
E: anti-neutrophil cytoplasmic
Give this one a try later!
B C
A E
Don't know?
4 of 31
Term
A 79-year-old woman was admitted for elective hip replacement
surgery. On examination, she was pale. There was 2-cm
splenomegaly and there were small discrete axillary lymph nodes.
haemoglobin 107 g/L (115-165)
white cell count 34.5 × 109/L (4.0-11.0)
platelet count 183 × 109/L (150-400)
What is the most likely diagnosis?
QUESTIONS & ANSWERS SOLVED
100% CORRECT!!
1 of 31
Term
A 30-year-old man had moved recently to the UK. He informed his
doctor that he had maturity-onset diabetes of the young.
What feature, if present, most strongly suggests that this is the
correct diagnosis?
A: a BMI of 30.0 kg/m2 (18.0-25.0)
B: a poor response to glipizide therapy
,C: a strong family history of diabetes mellitus
D: recurrent episodes of diabetic ketoacidosis
E: X-linked recessive inheritance
Give this one a try later!
B C
D E
Don't know?
2 of 31
Term
A 17-year-old boy presented with breathlessness and night sweats.
Investigations confirmed a diagnosis of Burkitt lymphoma.
What is the most likely underlying abnormality of gene expression?
A: expression of BCR-ABL
B: loss of p53
C: overexpression of BCL-2
D: overexpression of c-myc
,E: overexpression of JAK2
Give this one a try later!
B C
D E
Don't know?
3 of 31
Term
A 45-year-old woman presented with right flank pain. She had a 4-
year history of hypertension and progressive cognitive impairment.
On examination, she had livedo reticularis and tenderness in the
right flank. Her BP was 185/105 mmHg. Urinalysis showed blood 3+,
protein 1+.
Hb 129 g/L (115-165) WCC 8.7 × 109/L (4.0-11.0) PlTs 83 × 109/L (150-
400)
serum creatinine 106 µmol/L (60-110)
What antibody test is most likely to be positive?
A: anticardiolipin
, B: anticentromere
C: anti-glomerular basement membrane
D: antimitochondrial
E: anti-neutrophil cytoplasmic
E: anti-neutrophil cytoplasmic
Give this one a try later!
B C
A E
Don't know?
4 of 31
Term
A 79-year-old woman was admitted for elective hip replacement
surgery. On examination, she was pale. There was 2-cm
splenomegaly and there were small discrete axillary lymph nodes.
haemoglobin 107 g/L (115-165)
white cell count 34.5 × 109/L (4.0-11.0)
platelet count 183 × 109/L (150-400)
What is the most likely diagnosis?
