Certification _ and
Oncology
Immunotherapy
Nursing Study
Chemotherapy
Certification
Guide.pdf _ and
Oncology
Immunotherapy
Nursing Study
Certification
Guide.pdf _ Oncology Nursing Study Guide.pdf
Chemotherapy and Immunotherapy
Certification | Oncology Nursing Study
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Chemotherapy and ImmunotherapyChemotherapy
Certification _ and
Oncology
Immunotherapy
Nursing Study
Chemotherapy
Certification
Guide.pdf _ and
Oncology
Immunotherapy
Nursing Study
Certification
Guide.pdf _ Oncology Nursing Study Guide.pdf
,chemotherapy and immunotherapy certification.pdf chemotherapy and immunotherapy certification.pdf chemotherapy and immunotherapy certification.pdf
cell non specific agents alkylating agents, nitrosoureas, misc agents, antitumor abx
cell specific agents antimetabolites and plant alkaloids
alkylating agent MOA cause breakage in DNA interfering with replication and resulting in cell death
3 subcategories of alkylating agents 1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed
alkylating agents as they work similarly)
3. Nitrosoureas
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Common alkylating agents cyclophosphamide, cisplatin, carboplatin, oxaliplatin, carmustine
Cyclophosphamide adverse reaction hemorrhagic cystitis
Bladder protectant with administration of Mesna
cyclophosphamide
Oxaliplatin consideration refrain from cold drinks and cold air for 3-4 days
Hypersensitivity can occur with late doses of: carboplatin
High emetogenic agents nitrosoureas and alkylating agents
What is unique about nitrosoureas agents? Able to cross the blood-brain barrier; can be effective in treating some brain
tumors
Antimetabolites MOA work in the S phase, blocking DNA and RNA synthesis
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antimetabolite 4 subcategories folic acid agents, purine analogs, pyrimidine analogs, substituted ureas
Common antimetabolite drugs: 5 fu and methotrexate
Most-common cutaneous reaction seen with 5-FU Palmar-plantar erythrodysesthesia AKA hand-foot syndrome
antitumor abx MOA bind with DNA preventing DNA and RNA synthesis
2 subcategories of antitumor abx anthracyclines and non-anthracyclines
Common anthracycline antitumor abx: Daunorubicin
Doxorubicin
Epirubicin
Idarubicin
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