NURS 5220 ACTUAL EXAM 2025 WITH
COMPLETE QUESTIONS AND CORRECT
DETAILED ANSWERS ALREADY A+ GRADED
What are benzodiazepines?
ANSWER-A class of drugs used for anxiety and other
purposes.
What are the uses of benzodiazepines?
ANSWER-Sedation, hypnosis, muscle relaxation,
anxiolysis, anticonvulsant, amnesia, insomnia, alcohol
withdrawal.
What is the structure of benzodiazepines?
ANSWER-=Benzodiazepine ring with 2 nitrogen atoms at
positions 1 & 4, phenyl group at position 5, and an
electronegative group at position 7.
,How do benzodiazepines work?
ANSWER-They promote the binding of GABA to the
GABAA receptor, enhancing GABA-induced chloride
currents and inhibiting neuronal cell excitation.
How are benzodiazepines metabolized?
ANSWER-They are oxidized in the liver via CYP enzymes,
primarily CYP3A4.
What are the active metabolites of benzodiazepines?
ANSWER-Diazepam (with a half-life exceeding 100 hours)
and midazolam (rapidly metabolized to an α-
hydroxylated compound with biologic activity).
Which benzodiazepines have no active metabolites?
,ANSWER-Oxazepam, lorazepam, and temazepam.
What factors can alter the metabolism of
benzodiazepines?
ANSWER-Disease and age.
What is the duration of action of benzodiazepines
primarily determined by?
ANSWER-The α phase (distribution-redistribution from
CNS) dynamics rather than the rate of elimination.
What are the pharmacodynamic effects of
benzodiazepines on the CNS?
ANSWER-CNS depressant effects including anxiolysis,
sedation, sleep, anticonvulsant, amnesia, muscle
relaxation, and inhibition of alcohol withdrawal
symptoms.
, What effect do high doses of benzodiazepines have on
CMR02 & CBF?
ANSWER-They reduce CMR02 & CBF.
What effect do benzodiazepines have on the threshold to
local anesthetic-induced seizures?
ANSWER-They increase the threshold to local anesthetic-
induced seizures.
What is the dose-related effect of benzodiazepines on
anterograde amnesia?
ANSWER-They cause anterograde amnesia at high doses.
What are the potential drawbacks of benzodiazepine
use?
COMPLETE QUESTIONS AND CORRECT
DETAILED ANSWERS ALREADY A+ GRADED
What are benzodiazepines?
ANSWER-A class of drugs used for anxiety and other
purposes.
What are the uses of benzodiazepines?
ANSWER-Sedation, hypnosis, muscle relaxation,
anxiolysis, anticonvulsant, amnesia, insomnia, alcohol
withdrawal.
What is the structure of benzodiazepines?
ANSWER-=Benzodiazepine ring with 2 nitrogen atoms at
positions 1 & 4, phenyl group at position 5, and an
electronegative group at position 7.
,How do benzodiazepines work?
ANSWER-They promote the binding of GABA to the
GABAA receptor, enhancing GABA-induced chloride
currents and inhibiting neuronal cell excitation.
How are benzodiazepines metabolized?
ANSWER-They are oxidized in the liver via CYP enzymes,
primarily CYP3A4.
What are the active metabolites of benzodiazepines?
ANSWER-Diazepam (with a half-life exceeding 100 hours)
and midazolam (rapidly metabolized to an α-
hydroxylated compound with biologic activity).
Which benzodiazepines have no active metabolites?
,ANSWER-Oxazepam, lorazepam, and temazepam.
What factors can alter the metabolism of
benzodiazepines?
ANSWER-Disease and age.
What is the duration of action of benzodiazepines
primarily determined by?
ANSWER-The α phase (distribution-redistribution from
CNS) dynamics rather than the rate of elimination.
What are the pharmacodynamic effects of
benzodiazepines on the CNS?
ANSWER-CNS depressant effects including anxiolysis,
sedation, sleep, anticonvulsant, amnesia, muscle
relaxation, and inhibition of alcohol withdrawal
symptoms.
, What effect do high doses of benzodiazepines have on
CMR02 & CBF?
ANSWER-They reduce CMR02 & CBF.
What effect do benzodiazepines have on the threshold to
local anesthetic-induced seizures?
ANSWER-They increase the threshold to local anesthetic-
induced seizures.
What is the dose-related effect of benzodiazepines on
anterograde amnesia?
ANSWER-They cause anterograde amnesia at high doses.
What are the potential drawbacks of benzodiazepine
use?
