BIOC 339 Lecture 29 Exam Study Guide
fatty acids biosynthesis takes place in the - ANSWER cytoplasm
rate limiting step in fatty acid synthesis - ANSWER ACC
only fatty acid synthesized in mammals - ANSWER palmitic acid (16:0)
substrates for fatty acid synthesis - ANSWER acetyl-ACP and malonyl-ACP
acetyl-CoA reacts with ACP-SH to form - ANSWER acetyl-ACP
acetyl-CoA + ACP-SH -> acetyl-ACP reaction is catalyzed by - ANSWER MAT
acetyl-ACP is transferred to - ANSWER acetyl-synthase
acetyl-ACP -> acetyl-synthase transfer is catalyzed by - ANSWER KS
acetyl-CoA is converted to malonyl CoA by acetyl-CoA carboxylase (ACC) - ANSWER
first phase of FA synthesis
malynate-ACP formed from malonyl-ACP; sequential addition of two carbon units to
synthesis palmitic acid - ANSWER second phase of FA synthesis
dephosphorylation activates - ANSWER ACC
insulin activates - ANSWER ACC
phosphorylation activates - ANSWER ACC
glucagon and epinephrine activates - ANSWER ACC
synthesis of FA by the sequential addition of two carbon units by FA synthase - ANSWER
fatty acid biosynthesis (phase II)
acetyl-ACP and malonyl-ACP condensation by KS - ANSWER first reaction of FA
synthesis cycle
reduction by KR - ANSWER second reaction of FA synthesis cycle
dehydration by DH - ANSWER third reaction of FA synthesis cycle
reduction of ER - ANSWER fourth reaction of FA synthesis cycle
result of the first cycle of FA biosynthesis - ANSWER 4 carbon chain
4 carbon butyryl-ACP becomes - ANSWER butyric-synthase
each cycle the acyl group transferred to the alpha carbon of malonyl-CoA is _ carbons
longer than the previous cycle - ANSWER 2
, at the end of 6 cycles, a __ carbon chain palmitoyl-ACP is synthesized - ANSWER 16
intermediates are covalently linked to - ANSWER acyl carrier protein (ACP)
FA activator in FA biosynthesis; also used as an activator for beta oxidation - ANSWER
ACP
acetyl-CoA + CO2 -> - ANSWER malonyl-CoA
enzymes of the FA synthesis are packaged together in a complex called - ANSWER fatty
acid synthase (FAS)
longer, shorter and unsaturated FA are synthesized from - ANSWER palmitic acid
FA synthesis begins from the _____ ____ and proceeds toward the ______ _____ - ANSWER
methyl end, carboxyl end
X-shaped homodimer of two polypeptides - ANSWER FAS
each polypeptide contains _ catalytic domains and ACP - ANSWER 7
FAS synthesizes _ FA simultaneously - ANSWER 2
malonyl-CoA + ACP-SH -> - ANSWER malonyl-ACP
acetyl-COA carboxylase (ACC) carboxylates the acetyl-COA to synthesize _______; this is
an irreversible reaction - ANSWER malonyl-CoA
malonyl-CoA is activated by _________ to malonyl-ACP - ANSWER malonyl-acetyl
transferase
acetyl-ACP is transferred to ________ unit of FA synthase complex - ANSWER
ketosynthase (KS)
Fa synthesis begins with a ______ reaction - ANSWER condensation
acetyl group is transferred from malonyl group to form - ANSWER acetoacetyl-ACP
formation acetoacetyl-ACP is catalyzed by - ANSWER KS
fatty acids biosynthesis takes place in the - ANSWER cytoplasm
rate limiting step in fatty acid synthesis - ANSWER ACC
only fatty acid synthesized in mammals - ANSWER palmitic acid (16:0)
substrates for fatty acid synthesis - ANSWER acetyl-ACP and malonyl-ACP
acetyl-CoA reacts with ACP-SH to form - ANSWER acetyl-ACP
acetyl-CoA + ACP-SH -> acetyl-ACP reaction is catalyzed by - ANSWER MAT
acetyl-ACP is transferred to - ANSWER acetyl-synthase
acetyl-ACP -> acetyl-synthase transfer is catalyzed by - ANSWER KS
acetyl-CoA is converted to malonyl CoA by acetyl-CoA carboxylase (ACC) - ANSWER
first phase of FA synthesis
malynate-ACP formed from malonyl-ACP; sequential addition of two carbon units to
synthesis palmitic acid - ANSWER second phase of FA synthesis
dephosphorylation activates - ANSWER ACC
insulin activates - ANSWER ACC
phosphorylation activates - ANSWER ACC
glucagon and epinephrine activates - ANSWER ACC
synthesis of FA by the sequential addition of two carbon units by FA synthase - ANSWER
fatty acid biosynthesis (phase II)
acetyl-ACP and malonyl-ACP condensation by KS - ANSWER first reaction of FA
synthesis cycle
reduction by KR - ANSWER second reaction of FA synthesis cycle
dehydration by DH - ANSWER third reaction of FA synthesis cycle
reduction of ER - ANSWER fourth reaction of FA synthesis cycle
result of the first cycle of FA biosynthesis - ANSWER 4 carbon chain
4 carbon butyryl-ACP becomes - ANSWER butyric-synthase
each cycle the acyl group transferred to the alpha carbon of malonyl-CoA is _ carbons
longer than the previous cycle - ANSWER 2
, at the end of 6 cycles, a __ carbon chain palmitoyl-ACP is synthesized - ANSWER 16
intermediates are covalently linked to - ANSWER acyl carrier protein (ACP)
FA activator in FA biosynthesis; also used as an activator for beta oxidation - ANSWER
ACP
acetyl-CoA + CO2 -> - ANSWER malonyl-CoA
enzymes of the FA synthesis are packaged together in a complex called - ANSWER fatty
acid synthase (FAS)
longer, shorter and unsaturated FA are synthesized from - ANSWER palmitic acid
FA synthesis begins from the _____ ____ and proceeds toward the ______ _____ - ANSWER
methyl end, carboxyl end
X-shaped homodimer of two polypeptides - ANSWER FAS
each polypeptide contains _ catalytic domains and ACP - ANSWER 7
FAS synthesizes _ FA simultaneously - ANSWER 2
malonyl-CoA + ACP-SH -> - ANSWER malonyl-ACP
acetyl-COA carboxylase (ACC) carboxylates the acetyl-COA to synthesize _______; this is
an irreversible reaction - ANSWER malonyl-CoA
malonyl-CoA is activated by _________ to malonyl-ACP - ANSWER malonyl-acetyl
transferase
acetyl-ACP is transferred to ________ unit of FA synthase complex - ANSWER
ketosynthase (KS)
Fa synthesis begins with a ______ reaction - ANSWER condensation
acetyl group is transferred from malonyl group to form - ANSWER acetoacetyl-ACP
formation acetoacetyl-ACP is catalyzed by - ANSWER KS
