Nu664C Study Guide For Midterm Exam Questions With Correct Answers 2025

NU664C STUDY GUIDE FOR MIDTERM EXAM
QUESTIONS WITH CORRECT ANSWERS 2025
KnowNtheNrouteNofNadministrationNforNnewerNagentNasenapineN(Saphris)NandNwhatNinstructionsNshouldNbe
NgivenNtoNtheNpatientNregardingNadministration.N-NCORRECTNANSWERN-Route-NSublingual



NotNtoNeatNorNdrinkNforN10NminutesNafterNmedicationNadministration

NotNtoNswallowNorNchewNtheNcapsule.

AsenapineNisNanNatypicalNantipsychoticN(serotonin-
dopamineNantagonist,NasNaNmoodNstabilizer).NAsenapineNisNnotNabsorbedNafterNswallowingN(lessNthanN2%N
bioavailableNorally)NandNthusNmustNbeNadministeredNsublinguallyN(35%Nbioavailable),NasNswallowingNwoul
dNrenderNasenapineNinactive.

PatientsNshouldNbeNinstructedNtoNplaceNtheNtabletNunderNtheNtongueNandNallowNitNtoNdissolveNcompletely,N
whichNwillNoccurNinNseconds;NtabletNshouldNnotNbeNdivided,Ncrushed,Nchewed,NorNswallowed.

PatientsNmayNnotNeatNorNdrinkNforN10NminutesNfollowingNsublingualNadministrationNsoNthatNtheNdrugNinNth
eNoralNcavityNcanNbeNabsorbedNlocallyNandNnotNwashedNintoNtheNstomachN(whereNitNwouldNnotNbeNabsorb
ed).

DueNtoNrapidNonsetNofNaction,NcanNbeNusedNasNaNrapidNactingN"prn"NorN"asNneeded"NdoseNforNagitationNorN
transientNworseningNofNpsychosisNorNmaniaNinsteadNofNanNinjection.

TreatmentNshouldNbeNsuspendedNifNabsoluteNneutrophilNcountNfallsNbelowN1,000/mm3.



KnowNandNdescribeNtheNtopNatypicalNantipsychoticNwithNgreatestNincidenceNofNprolongedNQTcNinterval.N-
NCORRECTNANSWERN-ZiprasidoneN(Geodon).



NormalNQTcN=450.

>470,NCallNCardiologist

>500,NstopNallNmeds.

ZiprasidoneN(Geodon)NhasNbeenNassociatedNwithNaNdose-relatedNprolongationNofNtheNQTc

QTcNintervalNprolongationNisNgreatestNwithNziprasidoneNandNleastNwithNolanzapine.

ZiprasidoneN(Geodon)NanNatypicalNantipsychoticN(serotonin-dopamineNantagonist;Nsecond-
generationNantipsychotic;NalsoNaNmoodNstabilizer.

ZiprasidoneNisNprescribedNforNSchizophrenia,NdelayingNrelapseNinNschizophrenia,NacuteNagitationNinNschizo
phreniaN(intramuscular),NacuteNmania/mixedNmania,NbipolarNmaintenance,NotherNpsychoticNd/o,NbipolarN
depression,NbehavioralNdisturbancesNinNdementias,NbehavioralNdisturbancesNinNchildrenNandNadolescents,
NandNdisordersNassociatedNwithNproblemsNwithNimpulseNcontrol.

, ZiprasidoneNblocksNdopamineN2Nreceptors,NreducingNpositiveNsymptomsNofNpsychosisNandNstabilizingNaffec
tiveNsymptoms.NBlocksNserotoninN2ANreceptors,NcausingNenhancementNofNdopamineNreleaseNinNcertainNbr
ainNregionsNandNthusNreducingNmotorNsideNeffectsNandNpossibleNimprovingNcognitiveNandNaffectiveNsympt
oms.

EKGsNmayNbeNusefulNforNselectedNpatientsN(e.g.,NthoseNwithNpersonalNorNfamilyNhistoryNofNQTcNprolongatio
n;NcardiacNarrhythmia;NrecentNmyocardialNinfarction;NuncompensatedNheartNfailure;NorNthoseNtakingNagen
tsNthatNprolongNQTcNintervalN(suchNasNpimozide,Nthioridazine,NselectedNantiarrhythmics,Nmoxifloxacin,Nspa
rfloxacin,Netc.)

ZiprasidoneNprolongsNQTcNintervalNmoreNthanNsomeNotherNantipsychotics.

ZiprasidoneNisNassociatedNwithNrareNbutNseriousNskinNconditionNknownNasNDrugNReactionNwithNEosinophili
aN(DRESS).NDRESSNmayNbeginNasNaNrashNbutNcanNprogressNtoNotherNpartsNofNtheNbodyNandNcanNincludeNsym
ptomsNsuchNasNfever,NswollenNlymphNnodes,NswollenNface,NinflammationNofNorgans,NandNanNincreaseNinNw
hiteNbloodNcellsNknownNasNeosinophilia.NInNsomeNcases,NDRESSNcanNleadNtoNdeath.NClinic



KnowNwhichNantipsychoticsNhaveNspecificNinstructionsNforNminimumNfoodNintakeNorNdietNrestrictions.N-
NCORRECTNANSWERN-GeodonNbecauseNfoodNaffectsNtheNabsorptionNofNtheNdrug.



LurasidoneN-NLatuda



KnowNanNalternativeNatypicalNantipsychoticNforNaNpatientNwhoNhasNdevelopedNdiabetesNandNhasNaNsignific
antNweightNgainNfromNtreatmentNwithNolanzapine.N-NCORRECTNANSWERN-
AbilifyNorNGeodon,NorNLurasidoneN(Latuda)

BecauseNtheyNareNweightNneutralNorNcausesNminimalNweightNgain.



KnowNwhetherNaNpatientNisNdemonstratingNefficacyNtoNclozapineN500Nmg/dayNifNthisNweek'sNgranulocyteNc
ountNisNlessNthanN500mm3.NWhatNisNtheNmostNappropriateNrecommendationNforNdrugNtherapy?N-
NCORRECTNANSWERN-StopNtheNdrug,NbecauseNofNtheNriskNofNagranulocytosisNandNpatientNcanNbeNinfected.



TheNmostNappropriateNrecommendationNforNdrugNtherapyNisNtoNrepeatNCBCNweekly.

>N1500,NwatchNcarefullyNifNisNatN1000



KnowNtheNcommonNeffectsNofNsmokingNalongNwithNantipsychoticNdrugNtherapyNsuchNasNolanzapine.N-
NCORRECTNANSWERN-

SmokingNreducesNtheNlevelNofNOlanzapineNbecauseNofNitsNmetabolismNatNCYP450Nenzyme.