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Summary

Summary - Clinical Psychology (6463PS013Y)

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Summary of 12 pages for the course Clinical Psychology at UL

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Clinical Psychology

Cognitive-Behavioral Therapy

CBT
-​ an effective treatment for GAD, typically leading to reductions in worry, and a
study has shown that such therapy is equal to pharmaceutical treatment and
more effective 6 months after study completion
-​ includes the development of a functional analysis, providing information
through psychoeducation, experimentation with new behaviors and emotions
(exposition, relaxation), and a cognitive approach

Functional analysis
-​ makes it possible to specify where, when, with what frequency, with what
intensity, and under what circumstances the anxious response is triggered
-​ makes it possible to visualize the mental functioning of the person

Psychoeducation
-​ the next step after functional analysis
-​ crucial because it makes it possible to understand what the future therapeutic
tools will be and facilitates the increase in motivation to change
-​ patients begin to think in a different way about which behaviors could be the
most useful for them

The emotional and behavioral approach
-​ generally favored approach
-​ the therapist tries to teach relaxation in order to instruct how to create positive
emotions, not to manage negative ones
-​ double effect
i)​ the provision of a “psychological tool” to prepare for exposition
exercises; relaxation allows desensitization of anxiogenic situations
ii)​ a balancing of the general mood by adding “cognitive break times” in
thoughts and worries
-​ the behavioral dimension of CBT is the most important
-​ patients will be able to expose themselves to their own emotions and so will be
able to learn how to fight maintaining factors and avoidance behaviors that
perpetuate the disorder
-​ the cognitive process that is sought is habituation, acceptance of thoughts as
normal and nonblocking that initiates cognitive work

, -​ an example of mental exposition is the instruction “think the worst”, this
strategy allows a rapid and effective reduction in avoidance
-​ exposure to anxiety allows patients to remain in the presence of images related
to their possible concerns (disturbing images that are usually avoided), in order
to encourage emotional habituation
-​ patients can learn to tolerate their fears, which will allow them to think less
often and less intensely about their worries

The cognitive approach
-​ begins with a self-observation that patients will carry out on their own thoughts
-​ the aim of the cognitive work is to help patients take a step back from their
automatic thoughts and to be disjointed from those worries, adopted by the
third wave in CBT (mindfulness) to create its therapeutic program with a
different form
-​ therapy tends to modify the content of thoughts to reach a more objective
evaluation of situations
-​ the goal is to struggle against cognitive biases, such as overgeneralization or
maximization of danger
-​ a second evaluation of situations is possible by looking for objective indicators
that allow relativizing, it is also possible to evaluate the consequences of worry
and to understand subtle avoidance

GAD
-​ the presence of excessive anxiety and worry about a variety of topics, events,
or activities (main symptom)
-​ the search for reassurance is the second core element
-​ worry occurs more often than not for at least 6 months
-​ edginess or restlessness, difficulty sleeping, difficulty concentrating, and an
increase in muscle aches or soreness
-​ had been considered an “anxiety neurosis”
-​ factors common to anxiety disorders; anxious anticipation, cognitive biases,
and excessive concern
-​ specific factors that are not shared with other anxiety disorders; intolerance of
uncertainty, and excessive concerns in several important areas
-​ affects 6% of the general population if one considers the entire lifespan
-​ associated functional impairment is similar to that observed with major
depression
-​ in 60% of cases, major depression or another anxious disorder is present
-​ 90% of GAD sufferers are suspected to have a secondary anxious disorder,
such as social anxiety or panic disorder

Table of contents

  1. 01 Stress as a normal response to the coronavirus pandemic 4
  2. 02 Resilience in people with a psychiatric condition 5
  3. 03 The need for resilience at the societal level 6
  4. 04 Cognitive or brain abnormalities and genetic risks 8
  5. 05 -​cognitive function is related to brain structure in the healthy population, intelligence positively correlates with global brain volume 8
  6. 06 -​brain volume is not static, nor is IQ 8
  7. 07 -​intelligence is more related to the magnitude and timing of changes in brain structure than to brain structure, especially in early adolescence 8
  8. 08 -​schizophrenia patients showing cognitive decline over the first years of illness 8
  9. 09 -​genes that increase the risk of developing schizophrenia may drive the changes in both the brain and in cognition 8
  10. 10 -​genetic variation contributes up to 85% of the risk of developing the illness 8
  11. 11 -​brain volume and intelligence are highly heritable as well, with estimates up to 90% for total brain volume and 80% for IQ 8
  12. 12 -​25% of the total risk variance for schizophrenia is explained by lower IQ, and 4% of this variance is explained by smaller brain volume 8
  13. 13 -​brain changes appear to be primarily expressed in cortical thickness and white matter integrity 8
  14. 14 -​cognitive changes in the development of schizophrenia are related to abnormal connectivity rather than gross volume decreases 8
  15. 15 Brain Networks and Cognitive Changes in Schizophrenia 8
  16. 16 -​schizophrenia has been conceptualized as a disorder of brain connectivity since the illness was first defined 8
  17. 17 -​white matter connectivity is disrupted in schizophrenia, particularly in those areas that form the hubs for the main connections in the brain, due to their rich interconnectedness, these hubs are collectively called the “rich club” or the “connectome” of the brain 8
  18. 18 -​efficiency of this network, defined as the optimal relationship between functional connectivity and distance between brain areas 9
  19. 19 -​the cortex becomes thinner during adolescence, with its connecting white matter fibers increasing in volume 9
  20. 20 -​cortical changes are genetically controlled and are related to cognitive development during adolescence 9
  21. 21 -​the connectome’s efficiency itself and the relationship between intelligence and network efficiency are under genetic control (47% and 87%, respectively) 9
  22. 22 -​this effect in the rich club hubs appears to be specific for schizophrenia 9
  23. 23 -​brain connections present in humans but not in chimpanzees (those predominantly involved in semantic comprehension and language processing) are those affected in schizophrenia, suggesting that the same areas that have evolved in humans to acquire higher-order cognitive capabilities are those that are particularly vulnerable in the development of schizophrenia 9
  24. 24 Brain Networks and The Genetics of Schizophrenia 9
  25. 25 -​more than 200 genome-wide significant loci have been associated with the risk of schizophrenia 9
  26. 26 -​the strongest genetic relationship is that across the major histocompatibility complex (MHC) locus on chromosome 6, which is known for its role in immunity 9
  27. 27 -​allelic variation in C4 was related to increased risk for schizophrenia in proportion to its promotion of expression of C4A mRNA 9
  28. 28 -​increased levels of C4 mRNA expression in postmortem brain from individuals with schizophrenia compared with matched control subjects 9
  29. 29 -​proteins of the complement system are involved in activity-dependent synaptic pruning: weak synapses are tagged by these complement proteins and eliminated by microglia 9
  30. 30 -​microglia generated from stem cells of schizophrenia patients eliminated more synaptic structures, with both neuronal and microglial factors contributing 9
  31. 31 -​abnormalities in the synaptic pruning of prefrontal and temporal cerebral cortex normally characterizes adolescent brain maturation 9
  32. 32 -​excessive loss of gray matter and abnormally low numbers of synapses on cortical neurons in these brain regions (i.e., excessive synaptic pruning) are well-replicated pathological findings in schizophrenia 9
  33. 33 Translating Old Findings to New Initiatives 10
  34. 34 -​need to switch our focus from psychosis to cognition and the related brain development during childhood and early adolescence 10
  35. 35 -​it is clear that cognitive decline before the onset of psychosis is an important marker; interventions can be developed to halt this decline and prevent psychosis 10
  36. 36 -​a relationship was found between the polygenic risk score for schizophrenia and cortical thinning on MRI 10
  37. 37 -​a relationship between individuals with rare copy number variants CNVs and increased risk for schizophrenia and lower cognitive performance on neuropsychological tests 10
  38. 38 -​associations between greater polygenic loading for schizophrenia risk and poorer cognitive performance 10
  39. 39 -​numbers will still be too low to detect causes for relatively rare disorders such as schizophrenia (of the 10,000 subjects included, only 100 are expected to develop schizophrenia) 10
  40. 40 -​identification of SETD1A as a schizophrenia susceptibility gene; loss of function in this gene was recently shown to negatively affect the brain connectome 10
  41. 41 -​adolescents with the 22q11.2 deletion syndrome (22q11DS) have a 25-fold increased risk of developing schizophrenia 10
  42. 42 -​studying the offspring of patients with schizophrenia, is a good possibility for enriching samples for the development of schizophrenia 10

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February 6, 2025
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