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Blood-Brain Barrier - ✔✔A semipermeable membrane that separates
the circulating blood from the brain extracellular fluid, playing a
crucial role in protecting the brain from harmful substances.
Hepatic Metabolism - ✔✔The process by which drugs are broken
down by the liver into metabolites, often to inactivate the drug and
facilitate its excretion from the body.
Parenteral Dose - ✔✔A dose of medication administered by a route
other than the digestive tract, such as intravenously or
intramuscularly, bypassing the first-pass metabolism.
Tolerance - ✔✔The reduced response to a drug following repeated
use, requiring higher doses to achieve the same effect, often
associated with long-term opioid use.
Physical Dependence - ✔✔The state where the body has adapted to
the presence of a drug, leading to withdrawal symptoms upon abrupt
discontinuation of the drug.