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Summary - Human Physiology (WBFA022-03)

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A comprehensive summary for the course 'Human Physiology' from the Bachelor Pharmacy of the Rijksuniversiteit Groningen. Contains all the information from the lectures, so you are fully prepared for the exam.

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Uploaded on
January 30, 2025
Number of pages
12
Written in
2023/2024
Type
Summary

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VIKilill
Aims & components ·
Effects of
breathing :




Supply Or to body cells

Get rid off CO2 that is produced in cellular metabolism
·
Ventilation movement of air in and out of
lungs
blood
=
the
ratio
·
alveolar diffusion of between alveai and
exchange gasses
-




Perfusion
·
flow through the
=
blood
lungs
·
Gas transport supply hole body with oxygen
=




·
Tissue diffusion of between blood sells
exchange gas and
-




·
Cellular respiration use of by cells +
production of CO2
oxygen
=




The airways




Spirometry >
-
use to measure
long volumes and capacities Static
&

> UT 'normal'
tidal volume &2500ml amount of air with
breathing
=
,



>
Inspiratory reserve volume =
extra air we can breathe in
>
Expiratory reserve volume
=
extra air we can breathe out

Residual volume-air in the lungs we can't use >
-
1100 mL
·
Capacities :




Inspiratory capacity =
tidal volume +
inspiratory reserve volume
'
Vital
Capacity max air you can breath in =
.
and out

Total vital capacity + residual volume
lung capacity
=




functional residual capacity amount of air 'usually' =
in
lungs , when you
<
Physiological dead space per breath =
150 ml start
breathing
Ventilation >
- rib case in
expending the , causes pressure changes lungs
·
Inspiration contraction & increases
diaphragm volume
=




↳ Boyle's law :
PVi =
PeVe
1
.
lungs are expended >
-
depending on compliance
air will flow resistance
.
2 -
depending on

Expiration
·
relaxese volume decreases
diaphragm
=




·
To breath : forces must overcome
> retraction forces >
-
lung (wants to be small) + thorax (Wanis to expend (
resistance forces >
- tissue +
airway
·
Compliance =
volume change in response to a
pressure change
& AU/AP
us relaxation (/ Static) volume-
pressure curve



>
-
pressures

, Static volume- pneumothorax-klaplong
pressure curve




>
- equilibrium ,
FRC = o

us transmural pressure
= 0
lung + chest wall

us transmural +5
pressure lung
=




To measure intrapleural pressure place
in the
a manometer esophagus
Lung compliance o factors involved Is alreolar
in
pressure
the
measured
mouth
· Elastin fibres
and
collagen
-




< Surface tension of alveuli
L little
layer of fluid e resultant force insidet lung gets so smal

u
Surfactand produced by type 2
lung cells -
> lowers surface tension



Airway resistanc ·
80-90 %
·
caused by friction of
gasses in airways
·
determined by :




Ohm's law: R
=Mägen-Poisevice : =
o -
Je

-

8 cm MeO
intrapleural pressure
= R


Work of
breathing pressure difference put in effort
+
o to
get a

u area under the curve




expiration
·
energy that is released can be used for
·
more air flow & more resistance
·
respiratory minute volume (ventilation) =
VE =
fx VT
Part of energy of breathing lungs Triangle
·
used to expand the =




Increase in increase in and
during both breathing
&
·
resistance in work out

· Increase in compliance easier
>
- to expand the lungs

aveolar ventilation & air that
gets in awei
(Vo) Ve Va Up
Physiological
+
· deal =

space
:




↳ anatomical + alvedar => total =
150 m/
·
alveolar ventilation Va =
Fx Va
o
Gas Fick's law
exchange
:
$6.08
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