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Summary - Human Physiology (WBFA022-03)

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A comprehensive summary for the course 'Human Physiology' from the Bachelor Pharmacy of the Rijksuniversiteit Groningen. Contains all the information from the lectures, so you are fully prepared for the exam.

Institution
Course

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VIKilill
Aims & components ·
Effects of
breathing :




Supply Or to body cells

Get rid off CO2 that is produced in cellular metabolism
·
Ventilation movement of air in and out of
lungs
blood
=
the
ratio
·
alveolar diffusion of between alveai and
exchange gasses
-




Perfusion
·
flow through the
=
blood
lungs
·
Gas transport supply hole body with oxygen
=




·
Tissue diffusion of between blood sells
exchange gas and
-




·
Cellular respiration use of by cells +
production of CO2
oxygen
=




The airways




Spirometry >
-
use to measure
long volumes and capacities Static
&

> UT 'normal'
tidal volume &2500ml amount of air with
breathing
=
,



>
Inspiratory reserve volume =
extra air we can breathe in
>
Expiratory reserve volume
=
extra air we can breathe out

Residual volume-air in the lungs we can't use >
-
1100 mL
·
Capacities :




Inspiratory capacity =
tidal volume +
inspiratory reserve volume
'
Vital
Capacity max air you can breath in =
.
and out

Total vital capacity + residual volume
lung capacity
=




functional residual capacity amount of air 'usually' =
in
lungs , when you
<
Physiological dead space per breath =
150 ml start
breathing
Ventilation >
- rib case in
expending the , causes pressure changes lungs
·
Inspiration contraction & increases
diaphragm volume
=




↳ Boyle's law :
PVi =
PeVe
1
.
lungs are expended >
-
depending on compliance
air will flow resistance
.
2 -
depending on

Expiration
·
relaxese volume decreases
diaphragm
=




·
To breath : forces must overcome
> retraction forces >
-
lung (wants to be small) + thorax (Wanis to expend (
resistance forces >
- tissue +
airway
·
Compliance =
volume change in response to a
pressure change
& AU/AP
us relaxation (/ Static) volume-
pressure curve



>
-
pressures

, Static volume- pneumothorax-klaplong
pressure curve




>
- equilibrium ,
FRC = o

us transmural pressure
= 0
lung + chest wall

us transmural +5
pressure lung
=




To measure intrapleural pressure place
in the
a manometer esophagus
Lung compliance o factors involved Is alreolar
in
pressure
the
measured
mouth
· Elastin fibres
and
collagen
-




< Surface tension of alveuli
L little
layer of fluid e resultant force insidet lung gets so smal

u
Surfactand produced by type 2
lung cells -
> lowers surface tension



Airway resistanc ·
80-90 %
·
caused by friction of
gasses in airways
·
determined by :




Ohm's law: R
=Mägen-Poisevice : =
o -
Je

-

8 cm MeO
intrapleural pressure
= R


Work of
breathing pressure difference put in effort
+
o to
get a

u area under the curve




expiration
·
energy that is released can be used for
·
more air flow & more resistance
·
respiratory minute volume (ventilation) =
VE =
fx VT
Part of energy of breathing lungs Triangle
·
used to expand the =




Increase in increase in and
during both breathing
&
·
resistance in work out

· Increase in compliance easier
>
- to expand the lungs

aveolar ventilation & air that
gets in awei
(Vo) Ve Va Up
Physiological
+
· deal =

space
:




↳ anatomical + alvedar => total =
150 m/
·
alveolar ventilation Va =
Fx Va
o
Gas Fick's law
exchange
:

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Uploaded on
January 30, 2025
Number of pages
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Written in
2023/2024
Type
SUMMARY

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