Advanced pharmacology walden 6521 peds
Drug sensitivity variation in the very young results largely from
Organ System Immaturity
What are the five stages of pediatrics
premature (less than 36wks), full-term (36-40wks), neonates(first 4 post-natal
wks), infants (5-52wks), children(1-12years), adolescents (12-16 years)
What considerations have to be made for the pharmacokinetics in children?
-organ immaturity
-delayed drug elimination
gastric emptying time in infancy is both _____and _____
prolonged, and irregular
during the neonatal phase, intramuscular administration of medications is
slow and erratic
** by infancy, absorption becomes more rapid than in neonates and adults
during infancy transdermal absorption is
greater than in adolescence and adulthood (skin is thinner, more vascular)
**infants are at a greater risk for toxicity from topical drugs
Describe why there is more "free" concentrations of drug in infants verses adults,
intensifying the effects
infants do not have as much albumin, therefore there is less protein binding -
dosages for infants should be reduced
Drug sensitivity variation in the very young results largely from
Organ System Immaturity
What are the five stages of pediatrics
premature (less than 36wks), full-term (36-40wks), neonates(first 4 post-natal
wks), infants (5-52wks), children(1-12years), adolescents (12-16 years)
What considerations have to be made for the pharmacokinetics in children?
-organ immaturity
-delayed drug elimination
gastric emptying time in infancy is both _____and _____
prolonged, and irregular
during the neonatal phase, intramuscular administration of medications is
slow and erratic
** by infancy, absorption becomes more rapid than in neonates and adults
during infancy transdermal absorption is
greater than in adolescence and adulthood (skin is thinner, more vascular)
**infants are at a greater risk for toxicity from topical drugs
Describe why there is more "free" concentrations of drug in infants verses adults,
intensifying the effects
infants do not have as much albumin, therefore there is less protein binding -
dosages for infants should be reduced
