NR565 Midterm Exam / NR 565 Advanced Pharmacology Care – Questions With Solutions

NR565 Midterm Exam / NR 565 Advanced Pharmacolog v v v v v v v



y Care – Questions With Solutions
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ASCVD Risk Score Correct Ans - Used in children aged 9-11 and 19-
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21, and adults every 5 years after 20, with greater risk for those with diabetes a
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nd a risk score >7.5%
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Ezetimibe Use Correct Ans - v vvvvvvvvv v vv


Can be used in pregnancy/breastfeeding, as monotherapy or adjunct therapy
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with a statin or fibrate
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Ezetimibe Correct Ans - vvvvvvvvv v vv


Cholesterol Absorption Inhibitor that lowers cholesterol levels by decreasing
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absorption from the small intestine, without affecting triglycerides
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Lifestyle Changes for High Cholesterol Correct Ans - Non-
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drug measures to lower LDL, including diet, exercise, weight control, and smoki
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ng cessation
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Minimizing Side Effects Correct Ans - Non- v v vvvvvvvvv v vv vvv


statins like fibrates, ezetimibe, bile acid sequestrants, or statins for generally w
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ell-tolerated side effects v v




Organic Nitrates Therapeutic Action Correct Ans -
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Direct relaxant effect on vascular smooth muscles, dilation of coronary vessel
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s, reduction of preload and afterload, and promotion of vasodilation
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Ranolazine Contraindications Correct Ans - v vvvvvvvvv v vv


Inhibited by CYP3A4 inhibitors, increasing the risk of torsades de pointes, incl
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uding grapefruit juice, HIV protease inhibitors, macrolide antibiotics, azole anti
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fungal drugs, and some CCB v v v v




Statin Prescription Age v v vvvvvvvvv Correct Ans - Avoid in children under 10
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CCB Role in Variant Angina
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Promotes relaxation of coronary artery spasm, increasing cardiac oxygen sup
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ply

, HF Worsening Symptoms Medication
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Aldosterone antagonist that promotes myocardial remodeling and fibrosis to
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help with symptoms v v




CCB Stable Angina Correct Ans -
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Promotes relaxation of peripheral arterioles, decreasing afterload and reduci
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ng cardiac oxygen demand
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Nitro Patches Side Effect Response
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Prescribe a BB to help with increased heart rate
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CYP450 Inhibitors and Reducers Correct Ans -
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When not used correctly, they lead to increased side effects, adverse reactions
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, and toxicity
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Gouty Arthritis Treatment Decision
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In patients with infrequent flareups (less than three per year), NSAIDs are the
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first line agent for relieving pain
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Gouty Arthritis NSAID Ineffectiveness
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Prescribe a glucocorticoid (prednisone) or make dietary changes
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Colchicine Long Term Treatment Correct Ans - v v v vvvvvvvvv v vv


Considered for long term treatment if a person has three or more gouty attack
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s per year
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Colchicine Contraindications Correct Ans - v vvvvvvvvv v vv


Should not be taken with statins or CYP3A4 inhibitors
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Colchicine Adverse Effects Correct Ans - v v vvvvvvvvv v vv


Nausea, vomiting, diarrhea, myelosuppression, myopathy, and rhabdomyolys
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is

Allopurinol Long Term Effect Correct Ans - v v v vvvvvvvvv v vv


Can lead to severe cutaneous adverse reaction (SCAR) with symptoms like ras
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h, fever, eosinophilia, and liver and kidney function issues
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Febuxostat Co-Administration Correct Ans - Should be co- v vvvvvvvvv v vv vvv v v


administered with NSAIDs or colchicine v v v v