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Exam (elaborations)

Pharmacology 615 Practice Exam 2

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2024/2025 Written for academic year
Institution Pharm Nurs 615
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Pharmacology 615 Practice Exam 2 What drug requires CBC monitoring and how often should this be done? Carbamazepine Explain Carbamazepine's half-life When given as a single dose, the half-life is 30 hours, but when given continuously the half-life decreases to 15 hours because this drug is a strong inducer of hepatic enzymes

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Pharmacology 615 Practice Exam 2

WhatidrugirequiresiCBCimonitoringiandihowioftenishouldithisibeidone?i-iANSWERiCarbamazepine



ExplainiCarbamazepine'sihalf-lifei-iANSWERiWhenigiveniasiaisingleidose,itheihalf-
lifeiisi30ihours,ibutiwhenigivenicontinuouslyitheihalf-
lifeidecreasesitoi15ihoursibecauseithisidrugiisiaistrongiinduceriofihepaticienzymes



Whichimedicationiauto-inducesimetabolismi-iANSWERiCarbamazepine



Whatishouldifamiliesibeitaughtiregardingiseizuresi-
iANSWERiTeachifamiliesiaboutiprevention,ipatientisafety,iandiqualityiofilifeiissues.iMedicationsishouldino
tibeistoppediabruptlyiasithisicaniincreaseitheichanceiofiseizureiactivity



WhatielectrolyteiimbalanceiisinotediwithiTopiramatei(Topamax)i-
iANSWERiSerumiBicarbonateilevelsiareiaffected.




WhatiisitheipregnancyicategoryiforiValproatei(ValproiciAcid)i-
iANSWERiItiuseditoibeiCategoryiXibutitheiFDAidoesinotiuseitheseicategoriesianyimore.iThisimedicationish
ouldibeigivenionlyiafteritheifirstitrimester



Whatiinstructionsiwilliyouigiveitoiaiwomaniwhoiwantsitoigetipregnantiandiisitakingivalproateiforiseizureic
ontroli-
iANSWERiItiwouldibeirecommendedithatitheiwomaniswitchesitoianotherimedicationisuchiasiKeppraiatilea
stiuntiliafteritheifirstitrimester



WhyiareiTricycliciantidepressantsi(TCAs)iriskyi-
iANSWERiTheseiareiolderidrugs.iAlthoughitheyiareistilliusefuliinitreatingidepression,ithereiareimanyisideie
ffectsiandianioverdoseioniTCAsicanibeifatal

, WhatiareicommoniTCAisideieffectsi-
iANSWERidryimouth,isedation,iconstipation,iincreasediappetite,iblurredivision,itinnitus,ieuphoria,imania




ExplainitheicardiacieffectsiofiTCAi-
iANSWERiCardiaiconductionidisorderiisitheimostisignificantiriskiofiTCAs.iTCAsicanibehaveiasiantiarrhytmic
siandipossiblyiterminateiv-
fib,idecreaseicardiacicontractility,iandiincreaseicollateralibloodicirculationitoiischemiciheartimuscles



WhatiisiPhenelzinei(Nardil)i-
iANSWERiMonoamineiOxidaseiInhibitori(MAOI)iuseditoitreatirecalcitrantidepressioniasiwelliasiParkinson's
iandiseveraliotheridisorders




Whatiareitheiprecautionsiassociatediwithiphenelzinei(Nardil)i-
iANSWERiUsuallyireservediasilastiresortitreatmentidueitoirisks.iAvoidifoodsihighiinityramine.iTyramineiisif
oundiinifermentedifoods/drinksisuchiasialcohol,iwine,iandiagedicheeses.



Whatiisitheitimeiframeibetweenidiscontinuationiofiphenelzineianditheistartiofianotheritherapyi-
iANSWERi2iweeksishouldibeigivenisoithatiphenelzineiisifullyiclearedifromitheisystem




Whatiareitheis/sxiofihypertensiveicrisisi-
iANSWERiheadache,iheartipalpitations,istiffiorisoreineck,ichestitightness,itachycardia,isweating,idilatedip
upils



HowilongidoesiititakeiforiSSrRIsitoiproduceianieffectiforidepressionipatientsi-iANSWERi2-
6iweeks.imostiareiatifullieffectiwithini4iweeks



WheniisiBuspari(Buspirone)iandiandiSSRIicombinedi-
iANSWERiThisicombinationiisiusefuliforipatientsiwithiagitatediorianxiousidepression.iBuspariisihelpfuliinia
ugmentingitheiSSRI

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  • pharmacology 615 practice exam 2
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