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Maryville University Pharmacology 615 Exam 2

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Maryville University Pharmacology 615 Exam 2 Oseltamivir (Tamiflu) Neuramidase Inhibitor. Oral Antiviral for influenza A&B. Works by breaking the bond that attaches the viral particles to host cell. SE include headache, n/v, and CNS. Zanamivir (Relenza) Neuramidase Inhibitor. Inhaled Antiviral for influenza A&B. Works by breaking the bond that attaches the viral particles to host cell. Contraindicated for COPD. SE include headache, n/v, and CNS. Amantadine (Symmetrel) Inhaled Antiviral for Influenza A. Works by binding to ion channels formed by the membrane protein of viral envelope. High pKA so no absorption in stomach. CNS side effects like dizziness.

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Maryville University Pharmacology 615
Exam 2

OseltamivirX(Tamiflu)X-
XANSWERXNeuramidaseXInhibitor.XOralXAntiviralXforXinfluenzaXA&B.XWorksXbyXbreakingXtheXbondXthat
XattachesXtheXviralXparticlesXtoXhostXcell.XSEXincludeXheadache,Xn/v,XandXCNS.




ZanamivirX(Relenza)X-
XANSWERXNeuramidaseXInhibitor.XInhaledXAntiviralXforXinfluenzaXA&B.XWorksXbyXbreakingXtheXbondXt
hatXattachesXtheXviralXparticlesXtoXhostXcell.XContraindicatedXforXCOPD.XSEXincludeXheadache,Xn/
v,XandXCNS.



AmantadineX(Symmetrel)X-
XANSWERXInhaledXAntiviralXforXInfluenzaXA.XWorksXbyXbindingXtoXionXchannelsXformedXbyXtheXmembr
aneXproteinXofXviralXenvelope.XHighXpKAXsoXnoXabsorptionXinXstomach.XCNSXsideXeffectsXlikeXdizziness
.



RimantadineX(Flumadine)X-
XANSWERXInhaledXAntiviralXforXInfluenzaXA.XWorksXbyXbindingXtoXionXchannelsXformedXbyXtheXmembr
aneXproteinXofXviralXenvelope.XHighXpKAXsoXnoXabsorptionXinXstomach.XCNSXsideXeffectsXlikeXdizziness
.



Acyclovir,XValacyclovir,XFamciclovirX-
XANSWERXantiviralsXforXHSVXandXVZV.XBlockXanXenzymeXthatXisXessentialXinXproductionXofXnewXviruse
sXsoXvirusXcannotXreproduceXandXreplicate.XSEXincludeXheadachXandXnausea.



AntiviralsX-XANSWERXShouldXbeXtakensXASAPXforXeffectX(withinX48-
72XhrsXofXONSETXofXsymptoms).XForXshinglesXorXzoster,XwhenXyouXnoticeXtheXrash,XcomeXin.XForXinflu
enza,XearlyXsignsXofXflu,XcomeXinX(soreXthroat,XrunnyXnoseXQUICKXONSET).

,AmphotericinXBX-
XANSWERXPolyeneXantifungalXforXLIFEXTHREATENINGXfungalXinfections.XUsuallyXhaveXbeenXonXchemoX
orXpoorXimmuneXsystems.XDisruptsXtheXintegrityXofXfungalXcellXmembrane.



NystatinX-
XANSWERXPolyeneXantifungalXworksXbyXdisruptingXtheXintegrityXofXtheXfungalXcellXmembraneXbutXonl
yXworksXforXCANDIDAX(unlikeXammphotericinXb).Xskin,Xvaginal,Xoral/thrush.



itraconazole,Xfluconazole,Xposaconazole,XvoriconazoleX-
XANSWERXtriazoleXantifungals.XinhibitXcriticalXenzymeXthatXcausesXaXbuildupXofXtoxicXsubstanceXandXl
eadsXtoXincreasedXfungalXmembraneXpermeabilityX(cellXleaksXout).XCYPX450Xsystem.XlotsXofXdrugXinter
actions.XSEXincludeXn/v.



OtherX-azolesX(clotrimazole,Xketoconazole,XandXmiconazole)X-
XANSWERXimidazoleXantifungalsXareXlikeXtheXtraizoleXantifungalsXbutXareXindicatedXspecificallyXforXvul
vovaginal,Xoropharyngeal,XandXtineaXcandidiasXinfections.XinhibitXcriticalXenzymeXthatXcausesXaXbuildu
pXofXtoxicXsubstanceXandXleadsXtoXincreasedXfungalXmembraneXpermeabilityX(cellXleaksXout).XCYPX450
Xsystem.XlotsXofXdrugXinteractions.XSEXincludeXn/v.




allylaminesX(lamisil)X-
XANSWERXORALXantifungalXforXonchomycosis.XworksXlikeXtheXazoleXantifungalsXbutXhighlyXactiveXagai
nstXdermatophytesXsoXgoodXforXtoenailsXandXfingernailsXthatXareXinfected.XdoesXnotXworkXwellXagains
tXcandida.XLIVER/GIXissuesXbecauseXtakeXforX12Xweeeks.



Pen-LacX-XANSWERXTopicalXantifungalXindicatedXforXonychomycosis.



griseofulvinX-
XANSWERXantifungalXusedXforXtineaXinfections.XworksXwellXforXtineaXcapitisXandXworksXinXchildren.Xin
hibitsXmitosisXofXtheXfungalXelement.XliquidXform.XifXtakenXwithXsodaXcanXabsorbXbetter.



tolnaftateX(tinactin)X-XANSWERXtopicalXantifungalXusedXforXtineaXinfections.XtineaXcrurisXorXjockXitch.

, ethambutolX-
XANSWERXantitubercularXdrug.XinhibitsXsynthesisXofXmycolicXacidsX(importantXforXmycobacterialXwall).
XrapidlyXabsorbedXorally.XNOTXmonotherapy.XSEXisXopticXneuritis.




IsonazidX(INH)X-
XANSWERXantitubercularXdrug.XwellXabsorbed,XpenetratesXCNS.Xpotent.XperipheralXneuritisXandXhepati
tisXareXsideXeffects.



PyrazinamideX(PZA)X-
XANSWERXantitubercularXdrug.XwidelyXdistributedXthroughoutXallXbodyXtissues.XbacteriostaticXorXbacte
ricidalXdependingXonXdose.XhepaticXtoxicityXsideXeffect.



RifabutinX-
XANSWERXRifamycin.XantitubercularXdrug.XsemisyntheticXderivativeXofXtheXrifamycins.XwidelyXdistribut
ed.XinhibitsXDNA-dependentXRNAXpolymerase.X(inhibitsXproteinXsynthesis).



RifampinX-XANSWERXRifamycin.XantitubercularXdrug.XItXinhibitsXDNA-
dependentXRNAXpolymerase.X(inhibitsXproteinXsynthesis).XHighlyXproteinXboundXsoXlotsXofXpotentialXin
teractionsXwithXotherXmedications.XSideXeffectXincludesXn/v,Xred-
orangeXdiscolorationXofXurine,Xtears,Xsweat.XLotsXofXresistanceXissuesXBACTERICIDAL.



VancomycinX-
XANSWERXLypoglycopeptide:XtargetsXcellXwall.XBactericidalXandXactiveXagainstXgramXnegativeXbacteria.
XLARGEXhydrophilicXmoleculeXusuallyXgivenXIVX(cannotXpassXacrossXGIXcellXmembrane).XIsXgivenXPOXfo
rXcdiffXinfectionsXtoXactXtopicallyXinXtheXgut.



ErythromycinX(multipleXforms),XAzithromycin,XClarithromycinX-
XANSWERXMacrolides.XTargetXProteinXproduction.XBindXtoXbacterialXribosomeXtoXpreventXproteinXpro
duction.XBacterialXresistanceXisXanXissueXbecauseXofXoveruseXofXzithromaxXandXitsXconvenientXdoxingX
z-pakX(takeXforX5XdaysXandXlastsXforX10Xdays).



Tetracycline,Xdoxycycline,XminocyclineX-
XANSWERXTetracyclines.XTargetXProteinXProduction.XBACTERIOSTATIC.XenterXbacterialXcellsXbyXpassive

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  • maryville university pharmacology 615 exam
  • oseltamivir tamiflu neuramidase inhibitor oral
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  • amantadine symmetrel inhaled antiviral for influ

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