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NURS 615: ADVANCED PHARMACOTHERAPEUTICS Maryville university exam 4

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NURS 615: ADVANCED PHARMACOTHERAPEUTICS Maryville university exam 4 What is Tiotropium (SPIRIVA) used to treat? Used in the management/ maintenance treatment of chronic obstructive pulmonary disease (COPD) which includes chronic bronchitis and emphysema. What is the drug classification of Tiotropium? It is a long-acting, 24H anticholinergic-bronchodilator. It is a muscurinic receptor antagonist, often referred to as an antimuscurinic or anticholinergic agent. What is the mechanism of action of Tiotropium (SPIRIVA) It does not display selectivity for specific muscarinic receptors, when topically applied it acts mainly on M3 muscarinic receptors[8] located on smooth muscle cells and submucosal glands. This leads to a reduction in smooth muscle contraction and mucus secretion and thus produces a bronchodilatory effect.

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NURS 615: ADVANCED
PHARMACOTHERAPEUTICS Maryville
university exam 4

WhatSisSTiotropiumS(SPIRIVA)SusedStoStreat?SS-
SSANSWERSUsedSinStheSmanagement/
SmaintenanceStreatmentSofSchronicSobstructiveSpulmonarySdiseaseS(COPD)SwhichSincludesSchronicSbro
nchitisSandSemphysema.



WhatSisStheSdrugSclassificationSofSTiotropium?S-SANSWERS>ItSisSaSlong-acting,S24HSanticholinergic-
bronchodilator.

>ItSisSaSmuscurinicSreceptorSantagonist,SoftenSreferredStoSasSanSantimuscurinicSorSanticholinergicSagen
t.



WhatSisStheSmechanismSofSactionSofSTiotropiumS(SPIRIVA)S-
SANSWERSItSdoesSnotSdisplaySselectivitySforSspecificSmuscarinicSreceptors,SwhenStopicallySappliedSitSac
tsSmainlySonSM3SmuscarinicSreceptors[8]SlocatedSonSsmoothSmuscleScellsSandSsubmucosalSglands.SThi
sSleadsStoSaSreductionSinSsmoothSmuscleScontractionSandSmucusSsecretionSandSthusSproducesSaSbronc
hodilatorySeffect.



WhatSareStheSadverseSeffectsSwithSmontelukastS(Singular)S-
SANSWERSAnxiety,Saggression,Sdepression,SsuicidalSthoughts,




WhatSpatientSteachingSshouldSaccompanyStheSprescriptionSofSmontelukastS(Singulair)?S-
SANSWERSTeachSptSregardingSadverseSeffectSaboutSaggressionS,SdepressionSsuicidalSthoughtsSthatScoul
dSoccur



WhatSpatientSteachingSshouldSbeSprovidedSwhenSprescribingSinhaledScorticosteroids?S-
SANSWERSTheySshouldSbeStakenS2xSaSdaySeverySdaySforStheSuseSofSpreventionSofSasthma.

, RinseSmouthSafterSuseStoSpreventSoralSthrush.



WhatSethnicSbackgroundSshouldSnotSbeSprescribedSlong-actingSbetaSagonists?S-
SANSWERSAfricanSAmericans,SincreasedSincidenceSofSdeathSinSthisSpopulation




WhatSmedicationSwouldSyouSprescribeSforSbronchospasmSforSaSpatientStakingSpropranolol?S-
SANSWERSIpratropium




WhatSisStheSmechanismSofSactionSofSalbuterol?S-
SANSWERSActivationSofSbetaSadrenergicSreceptorsSleadStoSrelaxationSofStheSmuscleSofStheSlungSandSo
peningSandSdilationSofStheSairway

BetaSadrenergicSreceptorSareScoupledSwithSstimulatorySg-proteinSofStheStheSd-
anelylScyclase>SThisSenzymeSproducesStheSsecondSmessenngerScyclicSAMPS(inStheSlungsSitScAMPSdecre
asesScalciumSconcentrationSw/
inScellsSandSandSactivatesSproteinSkinaseSA.SBothSofStheseSinactivatesSmyosinSactivaseSkinaseSandSmyo
sinSlikeSphosphatase

TheySopenSlargeSconductantsSofShyperpolarizeSairwaySsmoothSmuscleScells



WhatSisStheSmechanismSofSactionSofSinhaledScorticosteroids?S-
SANSWERSExtremelySpotentSvasoconstrictiveSandSanti-inflammatorySactivity.




WhenSisSitSappropriateStoSuseSaSshortSactingSbetaSagonist?S-
SANSWERStheSdrugSofSchoiceSforSacuteStreatmentSofSasthmaSsymptomsSandSexacerbations.




ReliefSofSacuteSasthmaSattack.



LABASnotSusedSforSacuteSratherSusedSforSlongStermStreatmentSandSpreventionSofSasthmaS-
SANSWERSTrue

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