USAHS Pharmacology Final EXAM
QUESTIONS AND ANSWERS
What is the original NSAID? - ANSWER>>Asprin
What are the four properties of NSAIDs - ANSWER>>-Decrease Inflammation
-Decrease elevated body temp assoc. w/ fever
-Decrease blood clotting by inhibiting platelet aggragation (anticoagulation)
-Relieve mild-moderate pain (analgesia)
Antipyresis - ANSWER>>reducing an elevated body temperature
What do NSAIDs interphere with? - ANSWER>>With biosynthesis of
prostaglandins
What are prostaglandins? - ANSWER>>Lipid like compounds that are biologically
active ecosanoids and include thombroxanes and leukotrienes
Ecosanoids - ANSWER>>are diverse lipids chiefly derived from 20-carbon fatty
acid (arachidonic acid) found on all cell membranes.
How do Ecosanoids influence health? - ANSWER>>Cardiovascular, respiratory, GI,
Renal, nervous, and reproduction
Problems with excessive prostaglandin sythnesis (8): - ANSWER>>Inflammation
Fever
Pain
Dysmenorrhea
,Thrombus
Neoplasm
HTN
Colon Cancer
dysmenorrhea - ANSWER>>painful menstruation
arachnodonic acid will make - ANSWER>>cyclo-oxygenase
Cyclogenase will make - ANSWER>>prostalandins unless NSAIDs block that
MOA of NSAID action (normal cell) - ANSWER>>Normal cell ->
Physiologic stimulus (i.e excessive GI acid) -->
COX-1 "constitutive" -->
House keeping cells
Cox-1 - ANSWER>>"house keeping"
THE BENEFICIAL ONE
MOA of NSAID action (injured cell) - ANSWER>>Injured Cell --->
Inflammatory response --->
COX-2 "Injury induced" --->
, PGI2 and PGE2 ---->
INFLAMMATION
COX-2 - ANSWER>>triggers inflammation and pain
Emergency enzyme
COX that suppresses pain - ANSWER>>COX-2
Potent inhibitor of all COX activity - ANSWER>>Aspirin
Good for mild to mod pain, fever, vascular isorder, and cancer prevention -
ANSWER>>aspirin like drugs
Adverse affects of NSAIDs - ANSWER>>GI
CV
other (3)
GI affects from NSAID - ANSWER>>Discomfort
Hemorrhage
Ulceration
H2 Blocker
CV affects from NSAIDs - ANSWER>>Increase BP
Loss of vasoactive forms of PG cause clotting
Other affects from NSAIDs - ANSWER>>Toxiticty
Reyes syndrome (following flu)
Intolerance and hyper sensitivity
QUESTIONS AND ANSWERS
What is the original NSAID? - ANSWER>>Asprin
What are the four properties of NSAIDs - ANSWER>>-Decrease Inflammation
-Decrease elevated body temp assoc. w/ fever
-Decrease blood clotting by inhibiting platelet aggragation (anticoagulation)
-Relieve mild-moderate pain (analgesia)
Antipyresis - ANSWER>>reducing an elevated body temperature
What do NSAIDs interphere with? - ANSWER>>With biosynthesis of
prostaglandins
What are prostaglandins? - ANSWER>>Lipid like compounds that are biologically
active ecosanoids and include thombroxanes and leukotrienes
Ecosanoids - ANSWER>>are diverse lipids chiefly derived from 20-carbon fatty
acid (arachidonic acid) found on all cell membranes.
How do Ecosanoids influence health? - ANSWER>>Cardiovascular, respiratory, GI,
Renal, nervous, and reproduction
Problems with excessive prostaglandin sythnesis (8): - ANSWER>>Inflammation
Fever
Pain
Dysmenorrhea
,Thrombus
Neoplasm
HTN
Colon Cancer
dysmenorrhea - ANSWER>>painful menstruation
arachnodonic acid will make - ANSWER>>cyclo-oxygenase
Cyclogenase will make - ANSWER>>prostalandins unless NSAIDs block that
MOA of NSAID action (normal cell) - ANSWER>>Normal cell ->
Physiologic stimulus (i.e excessive GI acid) -->
COX-1 "constitutive" -->
House keeping cells
Cox-1 - ANSWER>>"house keeping"
THE BENEFICIAL ONE
MOA of NSAID action (injured cell) - ANSWER>>Injured Cell --->
Inflammatory response --->
COX-2 "Injury induced" --->
, PGI2 and PGE2 ---->
INFLAMMATION
COX-2 - ANSWER>>triggers inflammation and pain
Emergency enzyme
COX that suppresses pain - ANSWER>>COX-2
Potent inhibitor of all COX activity - ANSWER>>Aspirin
Good for mild to mod pain, fever, vascular isorder, and cancer prevention -
ANSWER>>aspirin like drugs
Adverse affects of NSAIDs - ANSWER>>GI
CV
other (3)
GI affects from NSAID - ANSWER>>Discomfort
Hemorrhage
Ulceration
H2 Blocker
CV affects from NSAIDs - ANSWER>>Increase BP
Loss of vasoactive forms of PG cause clotting
Other affects from NSAIDs - ANSWER>>Toxiticty
Reyes syndrome (following flu)
Intolerance and hyper sensitivity
