NAPSR EXAM QUIZ 10, CHAPTER 10
QUESTIONS AND ANSWERS REVISED
AND PASSED !!!.
(T/F) The aim of preclinical pharmacological studies is to obtain data on the safety and
effectiveness of the lead compound. - ANS True
(T/F) Toxicity information in preclinical studies helps provide confidence about a drug's
safety. - ANS True
(T/F)Pharmacological studies using animals are regulated under Good Laboratory
Practice. - ANS True
Why do drugs administered to patients only contain APIs? - ANS They don't
Which of the following does NOT affect a drug's ability to permeate membranes? - ANS
the drugs vesicles
Through which barriers can lipid-soluble drugs usually pass? - ANS cell membranes
How are weak acid drugs generally absorbed by the stomach? - ANS more quickly than
weak basic drugs
Which of the following routes of administration do NOT completely bypass the liver? -
ANS rectal administration
Why are intravenous drug dosages easier to control than drugs administered
transdermally? - ANS the entire dose is available in the bloodstream to be distributed to
the target site
Which of the following does NOT affect a drug's distribution to its target tissues? - ANS
all of these factors affect a drug's distribution to its target tissues
(1. the drug's lipid-solubility
2. the drugs polarity
3. the vascular nature of the drug's target tissue)
Which of these medical terms means "to apply the drug on the skin surface"? - ANS
Transdermal
(T/F) Carcinogenicity studies are carried out to identify the tumor-causing potential of a
drug. - ANS true
QUESTIONS AND ANSWERS REVISED
AND PASSED !!!.
(T/F) The aim of preclinical pharmacological studies is to obtain data on the safety and
effectiveness of the lead compound. - ANS True
(T/F) Toxicity information in preclinical studies helps provide confidence about a drug's
safety. - ANS True
(T/F)Pharmacological studies using animals are regulated under Good Laboratory
Practice. - ANS True
Why do drugs administered to patients only contain APIs? - ANS They don't
Which of the following does NOT affect a drug's ability to permeate membranes? - ANS
the drugs vesicles
Through which barriers can lipid-soluble drugs usually pass? - ANS cell membranes
How are weak acid drugs generally absorbed by the stomach? - ANS more quickly than
weak basic drugs
Which of the following routes of administration do NOT completely bypass the liver? -
ANS rectal administration
Why are intravenous drug dosages easier to control than drugs administered
transdermally? - ANS the entire dose is available in the bloodstream to be distributed to
the target site
Which of the following does NOT affect a drug's distribution to its target tissues? - ANS
all of these factors affect a drug's distribution to its target tissues
(1. the drug's lipid-solubility
2. the drugs polarity
3. the vascular nature of the drug's target tissue)
Which of these medical terms means "to apply the drug on the skin surface"? - ANS
Transdermal
(T/F) Carcinogenicity studies are carried out to identify the tumor-causing potential of a
drug. - ANS true
