MRCP questions with answers
What is Anagrelide? - ....🔰VERIFIED ANSWERS.... ✔✔It is used to control
platelets in essential thrombocythemia.
What is Asparaginase? - ....🔰VERIFIED ANSWERS.... ✔✔it is used in the
treatment of acute lymphoblastic leukaemia.
When do you do Venesection in Polycythemia vera? - ....🔰VERIFIED
ANSWERS.... ✔✔should aim to get the haematocrit below 0.45
How long should anticoagulation be continued in pregnancy? What leg is
frequently affected in DVT? - ....🔰VERIFIED ANSWERS....
✔✔Anticoagulation should continue until at least 6 weeks post partum in this
patient. Left leg.
What are the principal features of myelodysplasia ? - ....🔰VERIFIED
ANSWERS.... ✔✔B12 and folate levels must be normal to establish the
diagnosis. Blasts can be a feature of evolving myelodysplasia
A 25-year-old man was shot in the thigh at a local restaurant and was
moribund when brought in to A&E. He received 20 units of blood to maintain
normovolaemia. His coagulation parameters were PT 23 seconds, APTT 56
seconds and thrmobin time 25 seconds. His fibrinogen level was 0.6g/L. Which
of the following results can be predicted? - ....🔰VERIFIED ANSWERS....
✔✔Disseminated intravascular coagulation results from excess thrombin
generation arising from excessive tissue thromboplastin activation of
coagulation. This occurs in presence of reduced fibrinolysis, leading to
, bleeding diathesis. There are low levels of platelets (and hence a prolonged
bleeding time), protein C/S, antithrombin, factor VIII, factor VII and other
coagulation factors due to ongoing consumption and reduced synthesis. PAI
type 1 levels, D-Dimers are increased.
A 63-year-old man was admitted with fever and dyspnoea. He had been
previously well. Investigation revealed haemoglobin was 9.2 g/dL (normal
range 12-16.5), mean corpuscular volume 113 fL (normal range 80-100), white
cell count 14 x 109/L (normal range 4-11) and platelets 23 x 109/L (normal
range 150-400). His blood film is shown in the image above. What is the most
likely diagnosis? - ....🔰VERIFIED ANSWERS.... ✔✔Note the clumping of red
cells on the film caused by cold agglutinins, which are a feature of Mycoplasma
pneumonia
A 76-year-old man had been treated with fludarabine for Waldenström's
macroglobulinaemia 5 years ago. His IgM band had fallen from 36 g/l to a
plateau of 5 g/l. He was stable for 5 years but suddenly presented with Hb 6.7
gm/dl, platelets 79, creatinine 130 micromol/l, plasma viscosity 2.5 mPa/sec.
During blood transfusion, he developed a tachycardia and chest pain and was
transferred to CCU. The next day results showed Hb 7 g/dl, Coombs' test
positive, creatinine 377 micromol/l. What is the most likely diagnosis? - ....🔰
VERIFIED ANSWERS.... ✔✔Most Waldenström's and myeloma patients
relapse with a rise in their paraprotein; this man's IgM had risen to 29 g/l when
tested and the anaemia was a feature of active disease. He developed chest pain
due to an acute haemolytic transfusion reaction, and this caused the Coombs'
test to become positive. He had developed a Jka red cell antibody, which had
not previously been detected
How do you give a definitive diagnosis of PVR? - ....🔰VERIFIED ANSWERS....
✔✔PRV is confirmed by a red cell mass of greater than 125% of predicted.
Treatment is aimed at reducing the haematocrit to less than 45% by either
What is Anagrelide? - ....🔰VERIFIED ANSWERS.... ✔✔It is used to control
platelets in essential thrombocythemia.
What is Asparaginase? - ....🔰VERIFIED ANSWERS.... ✔✔it is used in the
treatment of acute lymphoblastic leukaemia.
When do you do Venesection in Polycythemia vera? - ....🔰VERIFIED
ANSWERS.... ✔✔should aim to get the haematocrit below 0.45
How long should anticoagulation be continued in pregnancy? What leg is
frequently affected in DVT? - ....🔰VERIFIED ANSWERS....
✔✔Anticoagulation should continue until at least 6 weeks post partum in this
patient. Left leg.
What are the principal features of myelodysplasia ? - ....🔰VERIFIED
ANSWERS.... ✔✔B12 and folate levels must be normal to establish the
diagnosis. Blasts can be a feature of evolving myelodysplasia
A 25-year-old man was shot in the thigh at a local restaurant and was
moribund when brought in to A&E. He received 20 units of blood to maintain
normovolaemia. His coagulation parameters were PT 23 seconds, APTT 56
seconds and thrmobin time 25 seconds. His fibrinogen level was 0.6g/L. Which
of the following results can be predicted? - ....🔰VERIFIED ANSWERS....
✔✔Disseminated intravascular coagulation results from excess thrombin
generation arising from excessive tissue thromboplastin activation of
coagulation. This occurs in presence of reduced fibrinolysis, leading to
, bleeding diathesis. There are low levels of platelets (and hence a prolonged
bleeding time), protein C/S, antithrombin, factor VIII, factor VII and other
coagulation factors due to ongoing consumption and reduced synthesis. PAI
type 1 levels, D-Dimers are increased.
A 63-year-old man was admitted with fever and dyspnoea. He had been
previously well. Investigation revealed haemoglobin was 9.2 g/dL (normal
range 12-16.5), mean corpuscular volume 113 fL (normal range 80-100), white
cell count 14 x 109/L (normal range 4-11) and platelets 23 x 109/L (normal
range 150-400). His blood film is shown in the image above. What is the most
likely diagnosis? - ....🔰VERIFIED ANSWERS.... ✔✔Note the clumping of red
cells on the film caused by cold agglutinins, which are a feature of Mycoplasma
pneumonia
A 76-year-old man had been treated with fludarabine for Waldenström's
macroglobulinaemia 5 years ago. His IgM band had fallen from 36 g/l to a
plateau of 5 g/l. He was stable for 5 years but suddenly presented with Hb 6.7
gm/dl, platelets 79, creatinine 130 micromol/l, plasma viscosity 2.5 mPa/sec.
During blood transfusion, he developed a tachycardia and chest pain and was
transferred to CCU. The next day results showed Hb 7 g/dl, Coombs' test
positive, creatinine 377 micromol/l. What is the most likely diagnosis? - ....🔰
VERIFIED ANSWERS.... ✔✔Most Waldenström's and myeloma patients
relapse with a rise in their paraprotein; this man's IgM had risen to 29 g/l when
tested and the anaemia was a feature of active disease. He developed chest pain
due to an acute haemolytic transfusion reaction, and this caused the Coombs'
test to become positive. He had developed a Jka red cell antibody, which had
not previously been detected
How do you give a definitive diagnosis of PVR? - ....🔰VERIFIED ANSWERS....
✔✔PRV is confirmed by a red cell mass of greater than 125% of predicted.
Treatment is aimed at reducing the haematocrit to less than 45% by either
