NURS 5334 University Of Texas - Arlington -NURS 5334-PHARM: Antimicrobials part 2/ Module 2 UTA Questions With Complete Solutions

NURS 5334-PHARM: Antimicrobials part 2/ Module 2 UTA
Questions With Complete Solutions

Tetracycline MOA
•Broad-spectrum antibiotics
•Inhibit protein synthesis
•Increasing bacterial resistance has emerged
Tetracyclines (Four medications in the tetracycline family)
*Each med ends in "Cycline"
-Tetracycline
-Doxycycline
-Demeclocycline
-Minocycline-Tetracycline
-Doxycycline
-Demeclocycline
-Minocycline
Tetracycline uses/ microbes
•Treatment of infectious disease
•Treatment of acne
•Peptic ulcer disease
•Periodontal disease
•Rheumatoid arthritis
•Mycoplasma pneumoniae
•Lyme disease
•Anthrax
•Helicobacter pylori
Tetracycline (adverse effects)
•Gastrointestinal irritation
•Effects on bone and teeth
•Superinfection
•Hepatotoxicity

, •Renal toxicity
•Photosensitivity and other effects
Tetracycline (avoid taking with)
•Milk products
•Calcium supplements
•Iron supplements
•Magnesium-containing laxatives
•Most antacids
Macrolides (Erythromycin)
•Broad-spectrum antibiotic
•Mechanism of action (MOA): Inhibition of protein synthesis
•Usually bacteriostatic but can be bactericidal
•Used if patient is allergic to penicillin
•Active against most gram-positive and some gram-negative
bacteria
Macrolides (Erythromycin) Therapeutic uses
•Whooping cough, acute diphtheria, Corynebacterium
diphtheriae, chlamydial infections, M. pneumoniae, group A
Streptococcus pyogenes
•May be used as an alternative to penicillin G in patients with
penicillin allergy
Macrolides (Erythromycin) Adverse effects
•Gastrointestinal
•QT prolongation and sudden cardiac death
•Superinfections, thrombophlebitis, transient hearing loss
Macrolides (Erythromycin) Drug interactions
levels of warfarin, theophylline & carbamazepine increase
Macroclide (Clindamycin) MOA
•Inhibits protein synthesis
•Active against most anaerobic bacteria (gram positive and gram
negative)