MSC Biologics Test Questions and Correct
Answers
Name 3 benefits to the use of a cadaveric allograft for tendon or ligament repair - CORRECT
ANSWER✅✅✅no donor site mobidity, reduced OR time due to no autograft harvest,
similar to success rate as autograft
name 3 drawbacks tot he use of cadaveric allograft for tendon or ligament repair - CORRECT
ANSWER✅✅✅laxity, disease, transmission, re-rupture rate, effusion (swelling)
what are the 3 basic biologic elements that make up the TRIAD necessary for tissue
transformation - CORRECT ANSWER✅✅✅cells, signals, scaffold
what is the scientific suffix for "cells" - CORRECT ANSWER✅✅✅-gensis
what is the scientific suffix for "signals" name several synonyms - CORRECT
ANSWER✅✅✅-inductive
-GF, regulators, hormones, cytokines (chemotaxis), chemokine, signaling proteins
what is the scientific suffix or "scaffold" name several synonyms - CORRECT
ANSWER✅✅✅-conductive
-matrix, template
what are the 2 different ways that biologics are regulated? - CORRECT
ANSWER✅✅✅510k and HTC-p
what criteria would qualify an orthobiologic as a medical device - CORRECT
ANSWER✅✅✅its an actual product, may have xenograph, and may contain small amount
of synthetic
,what criteria would qualify an orthobiologic as an HCT-P - CORRECT
ANSWER✅✅✅product contains 100% human tissues
meant for homologous use
creeping substitution - CORRECT ANSWER✅✅✅grafts are temporarily structures that
facilitate tissue healing. the body removes a little bit of the graph at at time and replaces it with
something better, something native
aseptic processing - CORRECT ANSWER✅✅✅SAL 10^-3
1:1000
protects cell viability
protects the structure or integrity of the scaffold
terminal sterilization - CORRECT ANSWER✅✅✅SAL 10^-6
1:1,000,000
process includes gamma radiation or ebeam
no viable living cells
autograft - CORRECT ANSWER✅✅✅obtained from your own body
allograft - CORRECT ANSWER✅✅✅human donor
xenograft - CORRECT ANSWER✅✅✅animal donor
synthetic - CORRECT ANSWER✅✅✅man-made
cells - CORRECT ANSWER✅✅✅-genic
MSC
, HSC
OPC
osteoblast
capable of rebuilding tissues that have been damaged or lost due to disease or injury
Signals - CORRECT ANSWER✅✅✅-osteoinductive
GF, Cytokine, chemokine, chemotaxis, regulator, hormone
drive and direct cellular activity
scaffold - CORRECT ANSWER✅✅✅-conductive
template, matrix
-collagen, HA
temporary structure the body will use as a framework for its own biological process
regenerative medicine - CORRECT ANSWER✅✅✅branch of medicine concerned with
developing therapies that regenerate or replace injured or defective cells, tissues, or organs to
restore or establish function and structure
bone are classified by shape - CORRECT ANSWER✅✅✅long (femur)
short
irregular (iliac crest)
flat (scapula)
epiphysis - CORRECT ANSWER✅✅✅located at the very ends of the long bones
metaphysis - CORRECT ANSWER✅✅✅between the epiphysis and diaphysis
diaphysis - CORRECT ANSWER✅✅✅elongated, shaft
Answers
Name 3 benefits to the use of a cadaveric allograft for tendon or ligament repair - CORRECT
ANSWER✅✅✅no donor site mobidity, reduced OR time due to no autograft harvest,
similar to success rate as autograft
name 3 drawbacks tot he use of cadaveric allograft for tendon or ligament repair - CORRECT
ANSWER✅✅✅laxity, disease, transmission, re-rupture rate, effusion (swelling)
what are the 3 basic biologic elements that make up the TRIAD necessary for tissue
transformation - CORRECT ANSWER✅✅✅cells, signals, scaffold
what is the scientific suffix for "cells" - CORRECT ANSWER✅✅✅-gensis
what is the scientific suffix for "signals" name several synonyms - CORRECT
ANSWER✅✅✅-inductive
-GF, regulators, hormones, cytokines (chemotaxis), chemokine, signaling proteins
what is the scientific suffix or "scaffold" name several synonyms - CORRECT
ANSWER✅✅✅-conductive
-matrix, template
what are the 2 different ways that biologics are regulated? - CORRECT
ANSWER✅✅✅510k and HTC-p
what criteria would qualify an orthobiologic as a medical device - CORRECT
ANSWER✅✅✅its an actual product, may have xenograph, and may contain small amount
of synthetic
,what criteria would qualify an orthobiologic as an HCT-P - CORRECT
ANSWER✅✅✅product contains 100% human tissues
meant for homologous use
creeping substitution - CORRECT ANSWER✅✅✅grafts are temporarily structures that
facilitate tissue healing. the body removes a little bit of the graph at at time and replaces it with
something better, something native
aseptic processing - CORRECT ANSWER✅✅✅SAL 10^-3
1:1000
protects cell viability
protects the structure or integrity of the scaffold
terminal sterilization - CORRECT ANSWER✅✅✅SAL 10^-6
1:1,000,000
process includes gamma radiation or ebeam
no viable living cells
autograft - CORRECT ANSWER✅✅✅obtained from your own body
allograft - CORRECT ANSWER✅✅✅human donor
xenograft - CORRECT ANSWER✅✅✅animal donor
synthetic - CORRECT ANSWER✅✅✅man-made
cells - CORRECT ANSWER✅✅✅-genic
MSC
, HSC
OPC
osteoblast
capable of rebuilding tissues that have been damaged or lost due to disease or injury
Signals - CORRECT ANSWER✅✅✅-osteoinductive
GF, Cytokine, chemokine, chemotaxis, regulator, hormone
drive and direct cellular activity
scaffold - CORRECT ANSWER✅✅✅-conductive
template, matrix
-collagen, HA
temporary structure the body will use as a framework for its own biological process
regenerative medicine - CORRECT ANSWER✅✅✅branch of medicine concerned with
developing therapies that regenerate or replace injured or defective cells, tissues, or organs to
restore or establish function and structure
bone are classified by shape - CORRECT ANSWER✅✅✅long (femur)
short
irregular (iliac crest)
flat (scapula)
epiphysis - CORRECT ANSWER✅✅✅located at the very ends of the long bones
metaphysis - CORRECT ANSWER✅✅✅between the epiphysis and diaphysis
diaphysis - CORRECT ANSWER✅✅✅elongated, shaft
