PHCH 667 final Exam2 - Questions with 100%
Correct Answers | Verified |
Urea is mainly produced in the liver to remove toxic ammonia. Although urea is almost
completely filtered at glomerulus, approximately 50% of the filtered urea is re-absorbed
by kidney tubules
A. True
B. False - ✔✔A. True
Which of the following is NOT true about the creatinine renal function test?
A. body fat does not affect SCr level
B. increased body muscle mass does not significantly change SCr
C. creatine, precursor of creatinine, is synthesized in the liver and stored in the muscle
as creatinine phosphate. creatinine is produced by cyclist ion of creatinine and then
escapes muscle cell membrane into the blood
D. SCr can be determined using Jaffe reaction, enzymatic assay, or HPLC method -
✔✔B. increased body muscle mass does not significantly change SCr
A patient, 11 years old, is prescribed imipenem IV for a gram-negative bacterial
infection. imipenem Overdose can cause seizure and other CNS adverse effects,
especially in patients with CNS disorders and/or compromised renal function. imipenem
dosage needs to be adjusted based on calculated CrCl or GFR. Which formula would be
most appropriate in this case to calculate CrCl or GFR?
A. Schwartz formula or Counahan-Baratt formula
B. MDRD formula
C. 24-hour urine collection method
D. CG equation - ✔✔A. schwartz formula or counahan-baratt formula
, drugs that inhibit tubular secretion of creatinine can cause false positive result for CKD,
due to an elevated serum creatinine concentration without any damage to renal
function. these drugs include..
A. cimetidine and probenecid
B. acetaminophen and ibuprofen
C. warfarin and sildenafil
D. fexofenadine and loratidine - ✔✔A. cimetidine and probenecid
During dipstick urinalysis, normal urine should not contain the following substances
except for..
A. glucose
b. protein
c. sodium and potassium
d. albumin and hemoglobin - ✔✔c. sodium and potassium
which of the following methods/assays is NOT used to determine creatinine serum
concentration?
A. immunoassay (detect using antibodies against creatinine)
B. Jaffe reaction (reaction of creatinine with picric acid to form a red-orange complex)
C. enzymatic assay (reaction of creatinine with creatinine iminohydrolase) - ✔✔A.
immunoassay (detect using antibodies against creatinine)
which of the following would elevate serum creatinine concentration?
A. dehydration
B. renal dysfunction caused by aminoglycosides
C. urinary tract obstruction
D. low calorie diet
Correct Answers | Verified |
Urea is mainly produced in the liver to remove toxic ammonia. Although urea is almost
completely filtered at glomerulus, approximately 50% of the filtered urea is re-absorbed
by kidney tubules
A. True
B. False - ✔✔A. True
Which of the following is NOT true about the creatinine renal function test?
A. body fat does not affect SCr level
B. increased body muscle mass does not significantly change SCr
C. creatine, precursor of creatinine, is synthesized in the liver and stored in the muscle
as creatinine phosphate. creatinine is produced by cyclist ion of creatinine and then
escapes muscle cell membrane into the blood
D. SCr can be determined using Jaffe reaction, enzymatic assay, or HPLC method -
✔✔B. increased body muscle mass does not significantly change SCr
A patient, 11 years old, is prescribed imipenem IV for a gram-negative bacterial
infection. imipenem Overdose can cause seizure and other CNS adverse effects,
especially in patients with CNS disorders and/or compromised renal function. imipenem
dosage needs to be adjusted based on calculated CrCl or GFR. Which formula would be
most appropriate in this case to calculate CrCl or GFR?
A. Schwartz formula or Counahan-Baratt formula
B. MDRD formula
C. 24-hour urine collection method
D. CG equation - ✔✔A. schwartz formula or counahan-baratt formula
, drugs that inhibit tubular secretion of creatinine can cause false positive result for CKD,
due to an elevated serum creatinine concentration without any damage to renal
function. these drugs include..
A. cimetidine and probenecid
B. acetaminophen and ibuprofen
C. warfarin and sildenafil
D. fexofenadine and loratidine - ✔✔A. cimetidine and probenecid
During dipstick urinalysis, normal urine should not contain the following substances
except for..
A. glucose
b. protein
c. sodium and potassium
d. albumin and hemoglobin - ✔✔c. sodium and potassium
which of the following methods/assays is NOT used to determine creatinine serum
concentration?
A. immunoassay (detect using antibodies against creatinine)
B. Jaffe reaction (reaction of creatinine with picric acid to form a red-orange complex)
C. enzymatic assay (reaction of creatinine with creatinine iminohydrolase) - ✔✔A.
immunoassay (detect using antibodies against creatinine)
which of the following would elevate serum creatinine concentration?
A. dehydration
B. renal dysfunction caused by aminoglycosides
C. urinary tract obstruction
D. low calorie diet
