WS T lymphocyte development MCQs Questions and Answers

WS T lymphocyte development MCQs Questions and Answers What components are required to successfully engage a TCR? Free protein Peptide bound by a MHC molecule Free peptide Polysaccharide bound by a MHC molecule Protein bound by a MHC molecule Free polysaccharide Peptide bound by a MHC molecule Question 2 1 / 1 pts Which thymocyte receptor is critical for early T lymphocyte development? IL-6 receptor IL-12 receptor IL-4 receptor IL-7 receptor IL-1 receptor IL-7 receptor Question 3 1 / 1 pts Which of the following cells are devoid of MHC-I molecules? Erythrocyte Dendritic cell Epithelial cell B lymphocyte Macrophage Erythrocyte Question 4 1 / 1 pts At which stage do double-positive thymocytes arise? Following positive selection Upon Notch1 ligand stimulation Upon the formation of the pre-TCR Upon the formation of a functional TCR a-chain Upon IL-7 stimulation Upon the formation of the pre-TCR Question 5 1 / 1 pts VJ and VDJ TCR chain gene rearrangement is dependent on which enzyme? AID (activation-induced cytidine deaminase) ADA (adenosine deaminase) RAG1/RAG2 (recombination-activating genes 1 & 2) AIRE (autoimmune regulator) Btk (Bruton's tyrosine kinase) RAG1/RAG2 (recombination-activating genes 1 & 2) Question 6 1 / 1 pts During the sequential pathway of selection, antigen presentation by cortical thymic epithelial cells to double-positive thymocytes equates to which process? T lymphocyte differentiation Positive selection T lymphocyte activation Central tolerance Negative selection Positive selection Question 7 1 / 1 pts During the sequential pathway of selection, the conjunction of (1) AIRE-derived promiscuous antigen presentation and (2) strong costimulatory signals provided by bone marrow-derived dendritic cells results in which of the following? T lymphocyte anergy Peripheral tolerance T lymphocyte differentiation T lymphocyte activation Central tolerance Central tolerance Question 8 1 / 1 pts Following T cell development in the thymus, some T lymphocytes with the potential to react to self-antigen nonetheless exit the thymus. Lack of stimulation of which receptor is responsible for peripheral tolerance? CD80/CD86 TCR CD8 CD4 CD28 CD28 Question 9 1 / 1 pts A 24-year-old woman presents with fever, dry cough, cephalgia, and myalgias. A rapid antigen test is positive for SARS-CoV-2 (a viral infection). What subset of effector CD4 T lymphocytes are prominent in this patient? Cytotoxic T lymphocyte TH17 TH1 Treg TH2 TH1