ATI Pharmacology Proctored Exam: Diverse, Expert-
Verified Questions and Solutions from Premier
Scholars Worldwide
A nurse is preparing to administer Cyclophosphamide IV to a client who has Hodgkin's
disease. Which of the following medications should the nurse expect to administer
concurrently with the chemotherapy to prevent an adverse effect of Cyclophosphamide?
A. Uroprotectant agent, such as mesna
B. Opioid, such as morphine
C. Loop diuretic, such as furosemide
D. H1 receptor antagonist, such as diphenhydramine - CORRECT ANSWER- -A (Mesna is a
uroprotectant agent that can help prevent hemorrhagic cystitis when administered IV with
a nitrogen mustard chemotherapy medication)
A nurse is preparing to administer Leucovorin to a client who has cancer and is receiving
chemotherapy with Methotrexate. Which of the following responses should the nurse use
when the client asks why Leucovorin is being given?
A. "Leucovorin reduces the risk of a transfusion reaction from methotrexate."
B. "Leucovorin increases platelet production and prevents bleeding."
C. "Leucovorin potentiates the cytotoxic effects of methotrexate."
D. "Leucovorin protects healthy cells from methotrexate's toxic effect." - CORRECT
ANSWER- -D (Leucovorin, a folic acid derivative and an antagonist to methotrexate, is given
within 12 hr of high doses of methotrexate to protect healthy cells from the toxic effects of
methotrexate)
A nurse is teaching a client who has breast cancer about Tamoxifen. Which of the following
adverse effects of tamoxifen should the nurse discuss with the client?
,A. Irregular heart beat
B. Abnormal uterine bleeding
C. Yellow sclera or dark-colored urine.
D. Difficulty swallowing - CORRECT ANSWER- -B (Vaginal discharge and bleeding are
adverse effects of tamoxifen. The client who takes tamoxifen is also at increased risk for
endometrial cancer, so any abnormal uterine bleeding should be carefully monitored and
evaluated)
A 12-month-old child just received the first measles, mumps, and rubella (mmR) vaccine.
For which of the following possible reactions to this vaccine should the nurse teach the
parents to monitor? (Select all that apply.)
A. Rash
B. Swollen glands
C. Bruising
D. Headache
E. Inconsolable crying - CORRECT ANSWER- -a, b, c
(A. A rash and fever can deelop in children 1 to 2 weeks following
mmR immunization.
B. Swollen glands can develop in children 1 to 2 weeks following
mmR immunization.
C. A temporary low platelet count, causing bruising or bleeding, can occur occasionally
following
mmR immunization)
, A nurse is caring for a group of clients who are not protected against Varicella. The nurse
should prepare to administer the Varicella vaccine at this time to which of the following
clients?
A. 24-year-old woman in the third trimester of pregnancy
B. 12-year-old child who has a severe allergy to neomycin
C. 2-month-old infant who has no health problems
D. 32-year-old man who has essential hypertension - CORRECT ANSWER- -D (A 32-year-old
man who has essential hypertension and did not receive two doses of varicella vaccine
earlier in life should be immunized. Essential hypertension is not a contraindication for this
vaccine)
A nurse is caring for a client who has breast cancer and asks why she is receiving a
combination therapy of Cyclophosphamide, Methotrexate, and Fluorouracil. The response
by the nurse should include that combination chemotherapy is used to do which of the
following? (Select all that apply.)
A. Decrease medication resistance
B. Attack cancer cells at different stages of cell growth
C. Block chemotherapy agent from entering healthy cells
D. Stimulate immune system
E. Decrease injury to normal body cells - CORRECT ANSWER- -a, b, e
(A.medication resistance is decreased with combination therapy because the chance of
developing resistance to several medication is less than to only one medication.
B. Each medication kills cancer cells at a
different stage of growth. A combination of medications can kill more cancer cells than
only one medication.
Verified Questions and Solutions from Premier
Scholars Worldwide
A nurse is preparing to administer Cyclophosphamide IV to a client who has Hodgkin's
disease. Which of the following medications should the nurse expect to administer
concurrently with the chemotherapy to prevent an adverse effect of Cyclophosphamide?
A. Uroprotectant agent, such as mesna
B. Opioid, such as morphine
C. Loop diuretic, such as furosemide
D. H1 receptor antagonist, such as diphenhydramine - CORRECT ANSWER- -A (Mesna is a
uroprotectant agent that can help prevent hemorrhagic cystitis when administered IV with
a nitrogen mustard chemotherapy medication)
A nurse is preparing to administer Leucovorin to a client who has cancer and is receiving
chemotherapy with Methotrexate. Which of the following responses should the nurse use
when the client asks why Leucovorin is being given?
A. "Leucovorin reduces the risk of a transfusion reaction from methotrexate."
B. "Leucovorin increases platelet production and prevents bleeding."
C. "Leucovorin potentiates the cytotoxic effects of methotrexate."
D. "Leucovorin protects healthy cells from methotrexate's toxic effect." - CORRECT
ANSWER- -D (Leucovorin, a folic acid derivative and an antagonist to methotrexate, is given
within 12 hr of high doses of methotrexate to protect healthy cells from the toxic effects of
methotrexate)
A nurse is teaching a client who has breast cancer about Tamoxifen. Which of the following
adverse effects of tamoxifen should the nurse discuss with the client?
,A. Irregular heart beat
B. Abnormal uterine bleeding
C. Yellow sclera or dark-colored urine.
D. Difficulty swallowing - CORRECT ANSWER- -B (Vaginal discharge and bleeding are
adverse effects of tamoxifen. The client who takes tamoxifen is also at increased risk for
endometrial cancer, so any abnormal uterine bleeding should be carefully monitored and
evaluated)
A 12-month-old child just received the first measles, mumps, and rubella (mmR) vaccine.
For which of the following possible reactions to this vaccine should the nurse teach the
parents to monitor? (Select all that apply.)
A. Rash
B. Swollen glands
C. Bruising
D. Headache
E. Inconsolable crying - CORRECT ANSWER- -a, b, c
(A. A rash and fever can deelop in children 1 to 2 weeks following
mmR immunization.
B. Swollen glands can develop in children 1 to 2 weeks following
mmR immunization.
C. A temporary low platelet count, causing bruising or bleeding, can occur occasionally
following
mmR immunization)
, A nurse is caring for a group of clients who are not protected against Varicella. The nurse
should prepare to administer the Varicella vaccine at this time to which of the following
clients?
A. 24-year-old woman in the third trimester of pregnancy
B. 12-year-old child who has a severe allergy to neomycin
C. 2-month-old infant who has no health problems
D. 32-year-old man who has essential hypertension - CORRECT ANSWER- -D (A 32-year-old
man who has essential hypertension and did not receive two doses of varicella vaccine
earlier in life should be immunized. Essential hypertension is not a contraindication for this
vaccine)
A nurse is caring for a client who has breast cancer and asks why she is receiving a
combination therapy of Cyclophosphamide, Methotrexate, and Fluorouracil. The response
by the nurse should include that combination chemotherapy is used to do which of the
following? (Select all that apply.)
A. Decrease medication resistance
B. Attack cancer cells at different stages of cell growth
C. Block chemotherapy agent from entering healthy cells
D. Stimulate immune system
E. Decrease injury to normal body cells - CORRECT ANSWER- -a, b, e
(A.medication resistance is decreased with combination therapy because the chance of
developing resistance to several medication is less than to only one medication.
B. Each medication kills cancer cells at a
different stage of growth. A combination of medications can kill more cancer cells than
only one medication.
